Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Cameron M. Chow"'
Autor:
Anindya Roy, Lei Shi, Ashley Chang, Xianchi Dong, Andres Fernandez, John C. Kraft, Jing Li, Viet Q. Le, Rebecca Viazzo Winegar, Gerald Maxwell Cherf, Dean Slocum, P. Daniel Poulson, Garrett E. Casper, Mary L. Vallecillo-Zúniga, Jonard Corpuz Valdoz, Marcos C. Miranda, Hua Bai, Yakov Kipnis, Audrey Olshefsky, Tanu Priya, Lauren Carter, Rashmi Ravichandran, Cameron M. Chow, Max R. Johnson, Suna Cheng, McKaela Smith, Catherine Overed-Sayer, Donna K. Finch, David Lowe, Asim K. Bera, Gustavo Matute-Bello, Timothy P. Birkland, Frank DiMaio, Ganesh Raghu, Jennifer R. Cochran, Lance J. Stewart, Melody G. Campbell, Pam M. Van Ry, Timothy Springer, David Baker
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract The RGD (Arg-Gly-Asp)-binding integrins αvβ6 and αvβ8 are clinically validated cancer and fibrosis targets of considerable therapeutic importance. Compounds that can discriminate between homologous αvβ6 and αvβ8 and other RGD integri
Externí odkaz:
https://doaj.org/article/e3c311aafe5446188603fdc35eee2511
Autor:
Yang Hsia, Rubul Mout, William Sheffler, Natasha I. Edman, Ivan Vulovic, Young-Jun Park, Rachel L. Redler, Matthew J. Bick, Asim K. Bera, Alexis Courbet, Alex Kang, T. J. Brunette, Una Nattermann, Evelyn Tsai, Ayesha Saleem, Cameron M. Chow, Damian Ekiert, Gira Bhabha, David Veesler, David Baker
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
De novo design of self-assembling protein nanostructures and materials is of significant interest, however design of complex, multi-component assemblies is challenging. Here, the authors present a stepwise hierarchical approach to build such assembli
Externí odkaz:
https://doaj.org/article/8bb80e33cedb4e58856a97a798a217fd
Autor:
Jason C. Klima, Lindsey A. Doyle, Justin Daho Lee, Michael Rappleye, Lauren A. Gagnon, Min Yen Lee, Emilia P. Barros, Anastassia A. Vorobieva, Jiayi Dou, Samantha Bremner, Jacob S. Quon, Cameron M. Chow, Lauren Carter, David L. Mack, Rommie E. Amaro, Joshua C. Vaughan, Andre Berndt, Barry L. Stoddard, David Baker
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Fluorescent protein reporters based on GFP exist, but have intrinsic disadvantages. Here the authors incorporate pH, Ca2+ and protein–protein interaction sensing modalities into de novo designed mini-fluorescence-activating proteins (mFAPs), with i
Externí odkaz:
https://doaj.org/article/5f1531b0f2b14a3183076ec5a9a3c859
Autor:
Jedediah M. Singer, Scott Novotney, Devin Strickland, Hugh K. Haddox, Nicholas Leiby, Gabriel J. Rocklin, Cameron M. Chow, Anindya Roy, Asim K. Bera, Francis C. Motta, Longxing Cao, Eva-Maria Strauch, Tamuka M. Chidyausiku, Alex Ford, Ethan Ho, Alexander Zaitzeff, Craig O. Mackenzie, Hamed Eramian, Frank DiMaio, Gevorg Grigoryan, Matthew Vaughn, Lance J. Stewart, David Baker, Eric Klavins
Publikováno v:
PLoS ONE, Vol 17, Iss 3 (2022)
Engineered proteins generally must possess a stable structure in order to achieve their designed function. Stable designs, however, are astronomically rare within the space of all possible amino acid sequences. As a consequence, many designs must be
Externí odkaz:
https://doaj.org/article/6bc977c80731465da8bb65f2719bfb0c
Autor:
Kejia Wu, Hua Bai, Ya-Ting Chang, Rachel Redler, Kerrie E. McNally, William Sheffler, T. J. Brunette, Derrick R. Hicks, Tomos E. Morgan, Tim J. Stevens, Adam Broerman, Inna Goreshnik, Michelle DeWitt, Cameron M. Chow, Yihang Shen, Lance Stewart, Emmanuel Derivery, Daniel Adriano Silva, Gira Bhabha, Damian C. Ekiert, David Baker
Publikováno v:
Nature. 616:581-589
General approaches for designing sequence-specific peptide-binding proteins would have wide utility in proteomics and synthetic biology. However, designing peptide-binding proteins is challenging, as most peptides do not have defined structures in is
Autor:
Ryan D. Kibler, Sangmin Lee, Madison A. Kennedy, Basile I. M. Wicky, Stella M. Lai, Marius M. Kostelic, Xinting Li, Cameron M. Chow, Lauren Carter, Vicki H. Wysocki, Barry L. Stoddard, David Baker
Pseudosymmetric hetero-oligomers with three or more unique subunits with overall structural (but not sequence) symmetry play key roles in biology, and systematic approaches for generating such proteinsde novowould provide new routes to controlling ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2628e2e7ede05f8a26f2b79c0c760e93
https://doi.org/10.1101/2023.04.07.535760
https://doi.org/10.1101/2023.04.07.535760
Autor:
David E. Kim, Davin R. Jensen, David Feldman, Doug Tischer, Ayesha Saleem, Cameron M. Chow, Xinting Li, Lauren Carter, Lukas Milles, Hannah Nguyen, Alex Kang, Asim K. Bera, Francis C. Peterson, Brian F. Volkman, Sergey Ovchinnikov, David Baker
Publikováno v:
Proceedings of the National Academy of Sciences. 120
This dataset contains the supplementary materialsfor "De novo design of small beta barrel proteins" Datasets. All dataset_SX.tar.gz files extract into a directory named data_archive. Dataset S1 (dataset_S1.tar.gz). Contains designs, input files (incl
Autor:
Kejia Wu, Hua Bai, Ya-Ting Chang, Rachel Redler, Kerrie E. McNally, William Sheffler, TJ Brunette, Derrick R. Hicks, Tomos E Morgan, Tim J Stevens, Adam Broerman, Inna Goreshnik, Michelle DeWitt, Cameron M. Chow, Yihang Shen, Lance Stewart, Emmanuel Derivery, Daniel Adriano Silva, Gira Bhabha, Damian Ekiert, David Baker
General approaches for designing sequence-specific peptide binding proteins would have wide utility in proteomics and synthetic biology. Although considerable progress has been made in designing proteins which bind to other proteins, the general pept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a7fff23e15bdae13920e1136bfa6c20
https://doi.org/10.1101/2022.11.14.514089
https://doi.org/10.1101/2022.11.14.514089
Autor:
Jason Z. Zhang, Hsien-Wei Yeh, Alexandra C. Walls, Basile I. M. Wicky, Kaitlin R. Sprouse, Laura A. VanBlargan, Rebecca Treger, Alfredo Quijano-Rubio, Minh N. Pham, John C. Kraft, Ian C. Haydon, Wei Yang, Michelle DeWitt, John E. Bowen, Cameron M. Chow, Lauren Carter, Rashmi Ravichandran, Mark H. Wener, Lance Stewart, David Veesler, Michael S. Diamond, Alexander L. Greninger, David M. Koelle, David Baker
Publikováno v:
Nature biotechnology, vol 40, iss 9
We designed a protein biosensor that uses thermodynamic coupling for sensitive and rapid detection of neutralizing antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants in serum. The biosensor is a switchable, caged
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::458cd9dfec1e4f5632dd9fdbf5b270ba
https://escholarship.org/uc/item/1b11v74r
https://escholarship.org/uc/item/1b11v74r
Autor:
Samantha Bremner, Lindsey Doyle, Andre Berndt, Jason C. Klima, David L. Mack, Jiayi Dou, Lauren Carter, Justin Daho Lee, Emilia P. Barros, Joshua C. Vaughan, Cameron M. Chow, David Baker, Min Yen Lee, Michael Rappleye, Rommie E. Amaro, Jacob S. Quon, Lauren A. Gagnon, Anastassia A. Vorobieva, Barry L. Stoddard
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature communications, vol 12, iss 1
Nature Communications
Nature communications, vol 12, iss 1
Nature Communications
Through the efforts of many groups, a wide range of fluorescent protein reporters and sensors based on green fluorescent protein and its relatives have been engineered in recent years. Here we explore the incorporation of sensing modalities into de n