Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Cameron M. Howard"'
Autor:
W. David Wilson, Caroline O'Hare, Daniel Hochhauser, Zarmeen T. Taherbhai, Moses Lee, Suzanna L. Bailey, Cameron M. Howard, Binh Nguyen, Karen L. Buchmueller, John A. Hartley
Publikováno v:
ChemBioChem. 6:2305-2311
A novel hairpin polyamide, ZT65B, containing a 3-methylpicolinate moiety was designed to target the inverted CCAAT box (ICB) of the human multidrug resistance 1 gene (MDR1) promoter. Binding of nuclear factor-Y (NF-Y) to the ICB site upregulates MDR1
Autor:
Cameron M. Howard, James A. Henry, N. M. Le, Moses Lee, Peter B. Uthe, Suzanna L. Bailey, Karen L. Buchmueller, Andrew M. Staples, Sarah M. Horick, Kari K. Cox
Publikováno v:
Letters in Drug Design & Discovery. 2:137-142
Autor:
N. Minh Le, Peter B. Uthe, Andrew M. Staples, Binh Nguyen, Cameron M. Howard, Karen L. Buchmueller, W. David Wilson, Kari K. Cox, Sarah M. Horick, Moses Lee, Kimberly A. O. Pacheco
Publikováno v:
Journal of the American Chemical Society. 127:742-750
Pyrrole (Py) and imidazole (Im) polyamides can be designed to target specific DNA sequences. The effect that the pyrrole and imidazole arrangement, plus DNA sequence, have on sequence specificity and binding affinity has been investigated using DNA m
Autor:
Cameron M. Howard, Binh Nguyen, Sarah M. Horick, Suzanna L. Bailey, Daniel Hochhauser, N. M. Le, James A. Henry, Moses Lee, Karen L. Buchmueller, Minal Kotecha, John A. Hartley, W. D. Wilson
Publikováno v:
Biochemistry. 43:12249-12257
The topoisomerase IIalpha promoter is regulated through transcription factor interactions with five inverted CCAAT boxes (ICBs). In confluent cancer cells, binding of nuclear factor Y to ICB2 represses the expression of this gene, contributing to res
Autor:
Jerome Kluza, John A. Hartley, Caroline O'Hare, Karen L. Buchmueller, Jim S. Sexton, Peter B. Uthe, Daniel Hochhauser, Lloyd V. Flores, Andrew M. Staples, W. David Wilson, Cameron M. Howard, Hilary Mackay, Moses Lee
Publikováno v:
Chembiochem : a European journal of chemical biology. 7(11)
The synthesis and DNA-binding properties of a novel naphthalimide-polyamide hairpin (3) designed to target the inverted CCAAT box 2 (ICB2) site on the topoisomerase IIalpha (topoIIalpha) promoter are described. The polyamide component of 3 was derive
Autor:
Moses Lee, Karen L. Buchmueller, Peter B. Uthe, Andrew M. Staples, Kari K. Cox, Cameron M. Howard, Suzanna L. Bailey, Binh Nguyen, W. David Wilson, Kimberly A. O. Pacheco, James A. Henry, Sarah M. Horick
Publikováno v:
Nucleic Acids Research
Polyamides containing an N-terminal formamido (f) group bind to the minor groove of DNA as staggered, antiparallel dimers in a sequence-specific manner. The formamido group increases the affinity and binding site size, and it promotes the molecules t
Autor:
Lloyd V. Flores, Andrew M. Staples, Hilary Mackay, Cameron M. Howard, Peter B. Uthe, Jim S. Sexton, Karen L. Buchmueller, W. David Wilson, Caroline O'Hare, Jerome Kluza, Daniel Hochhauser, John A. Hartley, Moses Lee
Publikováno v:
ChemBioChem; Nov2006, Vol. 7 Issue 11, p1722-1729, 8p
Autor:
Karen L. Buchmueller, Zarmeen Taherbhai, Cameron M. Howard, Suzanna L. Bailey, Binh Nguyen, Caroline O’Hare, Daniel Hochhauser, John A. Hartley, W. David Wilson, Moses Lee
Publikováno v:
ChemBioChem; Dec2005, Vol. 6 Issue 12, p2305-2311, 0p