Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Cameron J. Herting"'
Autor:
Michael Brandon Ware, Maggie Phillips, Christopher McQuinn, Mohammad Y. Zaidi, Hannah M. Knochelmann, Emily Greene, Brian Robinson, Cameron J. Herting, Thomas A. Mace, Zhengjia Chen, Chao Zhang, Matthew R. Farren, Amanda N. Ruggieri, Jacob S. Bowers, Reena Shakya, Alton B. Farris, Gregory Young, William E. Carson III, Bassel El-Rayes, Chrystal M. Paulos, Gregory B. Lesinski
Publikováno v:
JCI Insight, Vol 8, Iss 8 (2023)
This study aimed to enhance antitumor immune responses to pancreatic cancer via Ab-based blockade of IL-6 and cytotoxic T-lymphocyte–associated protein 4 (CTLA-4). Mice bearing s.c. or orthotopic pancreatic tumors were treated with blocking Abs to
Externí odkaz:
https://doaj.org/article/c9e661e36d174f30b84405ca8e2d56e4
Autor:
Victor Maximov, Zhihong Chen, Yun Wei, M. Hope Robinson, Cameron J. Herting, Nithya S. Shanmugam, Vasilisa A. Rudneva, Kelly C. Goldsmith, Tobey J. MacDonald, Paul A. Northcott, Dolores Hambardzumyan, Anna M. Kenney
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
The Sonic Hedgehog subgroup of medulloblastoma are characterised by the high infiltration of tumour-associated macrophages (TAMs). Here, the authors show that TAM numbers in patients are associated with better prognosis and that, consistently, in a m
Externí odkaz:
https://doaj.org/article/8d9bcf366d79419c9f9e965c3c18cd6f
Autor:
Ioannis Kaffes, Frank Szulzewsky, Zhihong Chen, Cameron J. Herting, Ben Gabanic, José E. Velázquez Vega, Jennifer Shelton, Jeffrey M. Switchenko, James L. Ross, Leon F. McSwain, Jason T. Huse, Bengt Westermark, Sven Nelander, Karin Forsberg-Nilsson, Lene Uhrbom, Naga Prathyusha Maturi, Patrick. J. Cimino, Eric C. Holland, Helmut Kettenmann, Cameron W. Brennan, Daniel J. Brat, Dolores Hambardzumyan
Publikováno v:
OncoImmunology, Vol 8, Iss 11 (2019)
Glioblastoma (GBM) is the most aggressive malignant primary brain tumor in adults, with a median survival of 14.6 months. Recent efforts have focused on identifying clinically relevant subgroups to improve our understanding of pathogenetic mechanisms
Externí odkaz:
https://doaj.org/article/99915def14e347129ecc08b39b7bf014
Autor:
Dolores Hambardzumyan, David H. Gutmann, Susanne A. Wolf, Sandra Seby, Bhakti Dwivedi, Rikke Rasmussen, Winnie W. Pong, Kai Nie, Virginia Alvarez Garcia, Cameron J. Herting, Xi Feng, Zhihong Chen
In glioblastoma (GBM), tumor-associated macrophages (TAM) represent up to one half of the cells of the tumor mass, including both infiltrating macrophages and resident brain microglia. In an effort to delineate the temporal and spatial dynamics of TA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ea452c19293e40a1c40bf9ef906a20a
https://doi.org/10.1158/0008-5472.c.6509349.v1
https://doi.org/10.1158/0008-5472.c.6509349.v1
Autor:
Candece L. Gladson, Petra Hamerlik, Jann N. Sarkaria, Dolores Hambardzumyan, Justin D. Lathia, Steven A. Toms, Markus Bredel, Maha A. Qadan, Cameron J. Herting, Amy S. Nowacki, Adam Lauko, Manmeet S. Ahluwalia, Monica E. Burgett, Cathleen R. Carlin, Gaëlle Müller-Greven
Additional details regarding the methods for cells, reagents, animal studies, immunofluorescence, transcytosis, and ELISA assays.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15e06deeb84451285219b134d663b651
https://doi.org/10.1158/1078-0432.22462752
https://doi.org/10.1158/1078-0432.22462752
Autor:
Dolores Hambardzumyan, David H. Gutmann, Susanne A. Wolf, Sandra Seby, Bhakti Dwivedi, Rikke Rasmussen, Winnie W. Pong, Kai Nie, Virginia Alvarez Garcia, Cameron J. Herting, Xi Feng, Zhihong Chen
Dynamic modulation of CCR2 and CX3CR1 in myeloid cells isolated from tumors. With the decrease of Ly6C intensity, the cells present increased CX3CR1-GFP intensity but decreased CCR2-RFP intensity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6179e8bd48542bc662f81b9cd0ce862e
https://doi.org/10.1158/0008-5472.22415670.v1
https://doi.org/10.1158/0008-5472.22415670.v1
Autor:
Candece L. Gladson, Petra Hamerlik, Jann N. Sarkaria, Dolores Hambardzumyan, Justin D. Lathia, Steven A. Toms, Markus Bredel, Maha A. Qadan, Cameron J. Herting, Amy S. Nowacki, Adam Lauko, Manmeet S. Ahluwalia, Monica E. Burgett, Cathleen R. Carlin, Gaëlle Müller-Greven
Figure S3 shows co-localization of different fractions of bevacizumab or human IgG (hIgG) with Rab4 or LAMP1 in CD133+ GBM cells in vitro, and of rat anti-mouse VEGF-A IgG in an established tumor in the immune competent mouse model of GBM in vivo, sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59d6e76ef338330b1d4f4a0e29fb4917
https://doi.org/10.1158/1078-0432.22462767
https://doi.org/10.1158/1078-0432.22462767
Autor:
Candece L. Gladson, Petra Hamerlik, Jann N. Sarkaria, Dolores Hambardzumyan, Justin D. Lathia, Steven A. Toms, Markus Bredel, Maha A. Qadan, Cameron J. Herting, Amy S. Nowacki, Adam Lauko, Manmeet S. Ahluwalia, Monica E. Burgett, Cathleen R. Carlin, Gaëlle Müller-Greven
Figure S1 shows that bevacizumab gains access to the perivascular tumor space and is internalized by tumor cells when administered to an orthotopic xenograft model of GBM and confirmation of cancer stem-like cell markers in vivo.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47804bbc80c983bc2a9d0ecc9cc07a0d
https://doi.org/10.1158/1078-0432.22462773.v1
https://doi.org/10.1158/1078-0432.22462773.v1
Autor:
Candece L. Gladson, Petra Hamerlik, Jann N. Sarkaria, Dolores Hambardzumyan, Justin D. Lathia, Steven A. Toms, Markus Bredel, Maha A. Qadan, Cameron J. Herting, Amy S. Nowacki, Adam Lauko, Manmeet S. Ahluwalia, Monica E. Burgett, Cathleen R. Carlin, Gaëlle Müller-Greven
Purpose: Bevacizumab, a humanized monoclonal antibody to VEGF, is used routinely in the treatment of patients with recurrent glioblastoma (GBM). However, very little is known regarding the effects of bevacizumab on the cells in the perivascular space
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16625d4bbc3953a5f69457664f008840
https://doi.org/10.1158/1078-0432.c.6525192
https://doi.org/10.1158/1078-0432.c.6525192
Autor:
Candece L. Gladson, Petra Hamerlik, Jann N. Sarkaria, Dolores Hambardzumyan, Justin D. Lathia, Steven A. Toms, Markus Bredel, Maha A. Qadan, Cameron J. Herting, Amy S. Nowacki, Adam Lauko, Manmeet S. Ahluwalia, Monica E. Burgett, Cathleen R. Carlin, Gaëlle Müller-Greven
Figure S7 shows bevacizumab is transcytosed across normal brain ECs and TECs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32eeb6ea3ae6e8d7e792876e12f6f703
https://doi.org/10.1158/1078-0432.22462755.v1
https://doi.org/10.1158/1078-0432.22462755.v1