Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Cameron D Buchman"'
Autor:
Monicah N Bwayi, Efren Garcia-Maldonado, Sergio C Chai, Boer Xie, Shirish Chodankar, Andrew D Huber, Jing Wu, Kavya Annu, William C Wright, Hyeong-Min Lee, Jayaraman Seetharaman, Jingheng Wang, Cameron D Buchman, Junmin Peng, Taosheng Chen
Publikováno v:
Nucleic acids research. 50(6)
The 48 human nuclear receptors (NRs) form a superfamily of transcription factors that regulate major physiological and pathological processes. Emerging evidence suggests that NR crosstalk can fundamentally change our understanding of NR biology, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::025ac0ee2762b893477d7d6fd92904f2
https://pubmed.ncbi.nlm.nih.gov/35212371
https://pubmed.ncbi.nlm.nih.gov/35212371
Autor:
Scott J. Barraza, Radu M. Suciu, Thomas D. Hurley, Mikhail Chtcherbinine, David Karnak, Euisik Yoon, Kara A. Bernstein, Ilya Kovalenko, Chun-Yi Chiang, Geeta Mehta, Ekaterina V. Vinogradova, Benjamin F. Cravatt, Brandt C. Huddle, Andrea H. Bild, Ronald J. Buckanovich, Iris L. Romero, Ilana Chefetz, Cynthia A. Morgan, Linda Hong, David B. Lombard, Edward Grimley, Scott D. Larsen, Charles N. Landen, Cameron D. Buchman, Meredith A. Morgan, Kun Yang
Publikováno v:
Cell Reports, Vol 26, Iss 11, Pp 3061-3075.e6 (2019)
Summary: Ovarian cancer is typified by the development of chemotherapy resistance. Chemotherapy resistance is associated with high aldehyde dehydrogenase (ALDH) enzymatic activity, increased cancer “stemness,” and expression of the stem cell mark
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a2cac15fa345ecc463e87abb08cc8ba
http://www.sciencedirect.com/science/article/pii/S2211124719302037
http://www.sciencedirect.com/science/article/pii/S2211124719302037
Autor:
Brandt C. Huddle, Bo Wen, Cameron D. Buchman, Bikash Debnath, Mikhail Chtcherbinine, Jeremy Felton, Cyrus Takahashi, Edward Grimley, Ronald J. Buckanovich, Scott D. Larsen, Stacy McGonigal, Nouri Neamati, Duxin Sun, Thomas D. Hurley, Shu Pan, Siwei Li, Shuai Mao
Publikováno v:
Eur J Med Chem
There is strong evidence that inhibition of one or more Aldehyde Dehydrogenase 1A (ALDH1A) isoforms may be beneficial in chemotherapy-resistant ovarian cancer and other tumor types. While many previous efforts have focused on development of ALDH1A1 s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::547d607c7e64542a6c0f897fe2c17150
https://pubmed.ncbi.nlm.nih.gov/33341649
https://pubmed.ncbi.nlm.nih.gov/33341649
Autor:
Cameron D. Buchman, Kinjal Majumder, William C. Wright, David J. Pintel, Wenwei Lin, Jing Wu, Jonathan Low, Taosheng Chen, Andrew D. Huber
Publikováno v:
Cell Mol Life Sci
Pregnane X receptor (PXR) is activated by chemicals to transcriptionally regulate drug disposition and possibly decrease drug efficacy and increase resistance, suggesting therapeutic value for PXR antagonists. We previously reported the antagonist SP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3dd23a2384ea5ac0da977e1d10d0e62
https://pubmed.ncbi.nlm.nih.gov/32232515
https://pubmed.ncbi.nlm.nih.gov/32232515
Publikováno v:
Expert Opinion on Drug Metabolism & Toxicology. 14:635-647
INTRODUCTION: Pregnane X receptor (PXR) and the constitutive androstane receptor (CAR) are two members of the nuclear receptor superfamily that play major roles in the expression of various drug metabolism enzymes and are known for their ligand promi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6522190adc8ecc5b5e60a993b9bac27c
https://doi.org/10.1080/17425255.2018.1476488
https://doi.org/10.1080/17425255.2018.1476488
Autor:
Thomas D. Hurley, Cameron D. Buchman
Publikováno v:
Journal of Medicinal Chemistry. 60:2439-2455
Aldehyde dehydrogenase 2 (ALDH2), one of 19 ALDH superfamily members, catalyzes the NAD+-dependent oxidation of aldehydes to their respective carboxylic acids. In this study, we further characterized the inhibition of four psoralen and coumarin deriv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14447db679f0ba1c8d9e16e673006e6e
https://doi.org/10.1021/acs.jmedchem.6b01825
https://doi.org/10.1021/acs.jmedchem.6b01825
Autor:
Cameron D. Buchman, Siwei Li, Jeremy Felton, Geeta Mehta, Bikash Debnath, Edward Grimley, Scott D. Larsen, Brandt C. Huddle, Ronald J. Buckanovich, Duxin Sun, Pooja Mehta, Mikhail Chtcherbinine, Thomas D. Hurley, Kun Yang, Cynthia A. Morgan, Nouri Neamati
Publikováno v:
Journal of medicinal chemistry. 61(19)
Aldehyde dehydrogenase (ALDH) activity is commonly used as a marker to identify cancer stem-like cells. The three ALDH1A isoforms have all been individually implicated in cancer stem-like cells and in chemoresistance; however, which isoform is prefer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::035234b9aea738665d2f4f1229c340fd
https://pubmed.ncbi.nlm.nih.gov/30221940
https://pubmed.ncbi.nlm.nih.gov/30221940
Publikováno v:
Journal of Chemical Information and Modeling
Molecular recognition is a complex process that involves a large ensemble of structures of the receptor and ligand. Yet, most structure-based virtual screening is carried out on a single structure typically from X-ray crystallography. Explicit-solven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c9d26ea26b9bf9207299de39a842a24
https://doi.org/10.1021/ci5002026
https://doi.org/10.1021/ci5002026
Publikováno v:
Chemico-biological interactions. 234
In humans, the aldehyde dehydrogenase superfamily consists of 19 isoenzymes which mostly catalyze the NAD(P)(+)-dependent oxidation of aldehydes. Many of these isoenzymes have overlapping substrate specificities and therefore their potential physiolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a10a93fb291e15b884406639a2a7149b
https://pubmed.ncbi.nlm.nih.gov/25641190
https://pubmed.ncbi.nlm.nih.gov/25641190