Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Cameron C. Hearne"'
Autor:
Melanie R. Silvis, Manohary Rajendram, Handuo Shi, Hendrik Osadnik, Andrew N. Gray, Spencer Cesar, Jason M. Peters, Cameron C. Hearne, Parth Kumar, Horia Todor, Kerwyn Casey Huang, Carol A. Gross
Publikováno v:
mBio, Vol 12, Iss 5 (2021)
Essential genes make up only ∼5 to 10% of the genetic complement in most organisms but occupy much of their protein synthesis and account for almost all antibiotic targets. Despite the importance of essential genes, their intractability has, until
Externí odkaz:
https://doaj.org/article/ac0ea87fcbd444e6a5571025f19f94b5
Autor:
Parth Kumar, Carol A. Gross, Hendrik Osadnik, Spencer Cesar, Melanie R. Silvis, Kerwyn Casey Huang, Cameron C. Hearne, Handuo Shi, Horia Todor, Jason M. Peters, Andrew N. Gray, Manohary Rajendram
Publikováno v:
mBio
mBio, Vol 12, Iss 5 (2021)
mBio, Vol 12, Iss 5 (2021)
CRISPR interference (CRISPRi) has facilitated the study of essential genes in diverse organisms using both high-throughput and targeted approaches. Despite the promise of this technique, no comprehensive arrayed CRISPRi library targeting essential ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb7411aca698d520e96b5ae041d7d83f
https://pubmed.ncbi.nlm.nih.gov/34634934
https://pubmed.ncbi.nlm.nih.gov/34634934
Autor:
Gary E. Heussler, Oren S. Rosenberg, Melanie R. Silvis, Alan D. Grossman, Rachel J. Dutton, Byoung-Mo Koo, Cameron C. Hearne, Carol A. Gross, Jason M. Peters, Joanne N. Engel, Hendrik Osadnik, Joseph E. Peters, Ramiro Patino, Jiuxin Qu, M. Michael Harden, Candy H. S. Lu, Yuki F. Inclan, John S. Hawkins
Publikováno v:
Nature Microbiology. 4:244-250
The vast majority of bacteria, including human pathogens and microbiome species, lack genetic tools needed to systematically associate genes with phenotypes. This is the major impediment to understanding the fundamental contributions of genes and gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7b9f3bec9c4eb299619667ab39be2bb
https://doi.org/10.1038/s41564-018-0327-z
https://doi.org/10.1038/s41564-018-0327-z
Autor:
Hendrik Osadnik, Byoung-Mo Koo, Jason M. Peters, Melanie R. Silvis, Jonathan S. Weissman, Cameron C. Hearne, Carol A. Gross, John S. Hawkins, Horia Todor, Marco Jost
Publikováno v:
Cell Syst
Summary Essential genes are the hubs of cellular networks, but lack of high-throughput methods for titrating gene expression has limited our understanding of the fitness landscapes against which their expression levels are optimized. We developed a m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89c111d96514e0b16d7ee3d849578250
https://pubmed.ncbi.nlm.nih.gov/33080209
https://pubmed.ncbi.nlm.nih.gov/33080209
Autor:
Candy H. S. Lu, Rachel J. Dutton, Byoung-Mo Koo, Ramiro Patino, Oren S. Rosenberg, Joanne N. Engel, Hendrik Osadnik, Carol A. Gross, Yuki F. Inclan, Joseph E. Peters, Cameron C. Hearne, Gary E. Heussler, John S. Hawkins, M. Michael Harden, Alan D. Grossman, Jason M. Peters
Introductory paragraphThe vast majority of bacteria, including human pathogens and microbiome species, lack genetic tools needed to systematically associate genes with phenotypes. This is the major impediment to understanding the fundamental contribu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c64451449459b3cae318c444a22e4789
Autor:
Song Y; Research Group Insect Gut Microbiology and Symbiosis, Max Planck Institute for Terrestrial Microbiologygrid.419554.8, Marburg, Germany., Pfeiffer F; Research Group Insect Gut Microbiology and Symbiosis, Max Planck Institute for Terrestrial Microbiologygrid.419554.8, Marburg, Germany., Radek R; Institute of Biology/Zoology, Free University of Berlin, Berlin, Germany., Hearne C; Research Group Insect Gut Microbiology and Symbiosis, Max Planck Institute for Terrestrial Microbiologygrid.419554.8, Marburg, Germany., Hervé V; Research Group Insect Gut Microbiology and Symbiosis, Max Planck Institute for Terrestrial Microbiologygrid.419554.8, Marburg, Germany., Brune A; Research Group Insect Gut Microbiology and Symbiosis, Max Planck Institute for Terrestrial Microbiologygrid.419554.8, Marburg, Germany.
Publikováno v:
Applied and environmental microbiology [Appl Environ Microbiol] 2022 Jul 26; Vol. 88 (14), pp. e0050322. Date of Electronic Publication: 2022 Jul 11.