Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Cameron B. Gundersen"'
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e36049 (2012)
A key objective of stem cell biology is to create physiologically relevant cells suitable for modeling disease pathologies in vitro. Much progress towards this goal has been made in the area of motor neuron (MN) disease through the development of met
Externí odkaz:
https://doaj.org/article/25bf8d71cc134ced9b74f8fd1e4d1c17
Autor:
Cameron B. Gundersen
Publikováno v:
Neuroscience. 439
This mini-review starts with a summary of the crucial contributions Ricardo Miledi made to our understanding of how the action potential triggers fast, synchronous transmitter release. It then transitions to the discovery of synaptotagmin and its rol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c479fa76f7b9f697d3fa560ba4da7564
https://pubmed.ncbi.nlm.nih.gov/31047980
https://pubmed.ncbi.nlm.nih.gov/31047980
Autor:
Cameron B. Gundersen
Publikováno v:
Progress in Neurobiology. 188:101758
Cysteine string protein (CSP) was discovered by use of a synapse-specific, monoclonal antibody to screen a cDNA expression library in Drosophila. A vertebrate CSP homolog was later identified and shown to co-purify with synaptic vesicles. CSP-α is n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f73ad5b1e48470cd980642d4f0a67c2a
https://doi.org/10.1016/j.pneurobio.2020.101758
https://doi.org/10.1016/j.pneurobio.2020.101758
Insights into the structure and molecular topography of the fatty acylated domain of synaptotagmin-1
Publikováno v:
Biochimica et biophysica acta. Biomembranes. 1861(3)
Abundant attention has focused on synaptotagmin's C2 domains, but less is known about the structure and function of its other regions. Here, we synthesized the N-acetylated, C-end amidated and Cys-palmitated peptide (VLTCCFCICK KCLFKKKNKK K) which in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b59881aa3bbafc87ec4b0aa460a97fc3
https://pubmed.ncbi.nlm.nih.gov/30615859
https://pubmed.ncbi.nlm.nih.gov/30615859
Autor:
Cameron B. Gundersen
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 18, Iss 7, p 1582 (2017)
International Journal of Molecular Sciences, Vol 18, Iss 7, p 1582 (2017)
Parallel zippering of the SNARE domains of syntaxin 1A/B, SNAP-25, and VAMP/synaptobrevin 2 is widely regarded as supplying the driving force for exocytotic events at nerve terminals and elsewhere. However, in spite of intensive research, no consensu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acb44bd039fd177462227654edc7d10d
https://pubmed.ncbi.nlm.nih.gov/28753981
https://pubmed.ncbi.nlm.nih.gov/28753981
Autor:
Cameron B. Gundersen
Publikováno v:
Frontiers in Molecular Neuroscience
Contemporary models of neurotransmitter release invoke direct or indirect interactions between the Ca2+ sensor, synaptotagmin and the incompletely zippered soluble, N-ethyl-maleimide-sensitive factor attachment protein receptor (SNARE) complex. Howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35b06011338c816b9e80d92b29e9978a
http://europepmc.org/articles/PMC5321675
http://europepmc.org/articles/PMC5321675
Publikováno v:
Biophysical Journal. 114:607a-608a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71980539286381770f3bc13571baa403
https://doi.org/10.1016/j.bpj.2017.11.3320
https://doi.org/10.1016/j.bpj.2017.11.3320
Autor:
Joy A. Umbach, Cameron B. Gundersen
Publikováno v:
Journal of theoretical biology, vol 332
Gundersen, CB; & Umbach, JA. (2013). Synaptotagmins 1 and 2 as mediators of rapid exocytosis at nerve terminals: The dyad hypothesis. Journal of Theoretical Biology, 332, 149-160. doi: 10.1016/j.jtbi.2013.04.029. UCLA: Retrieved from: http://www.escholarship.org/uc/item/5760s9wm
Gundersen, CB; & Umbach, JA. (2013). Synaptotagmins 1 and 2 as mediators of rapid exocytosis at nerve terminals: The dyad hypothesis. Journal of Theoretical Biology, 332, 149-160. doi: 10.1016/j.jtbi.2013.04.029. UCLA: Retrieved from: http://www.escholarship.org/uc/item/5760s9wm
The dyad model was developed to explain the extremely rapid kinetics of synaptic vesicle exocytosis. In contrast to most hypotheses which invoke interactions among synaptotagmins, SNAREs and other regulatory molecules, the dyad model features a quart
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3734b629d2a069b181f4d66ee05e4db8
https://doi.org/10.1016/j.jtbi.2013.04.029
https://doi.org/10.1016/j.jtbi.2013.04.029
Publikováno v:
Journal of Neurochemistry. 75:2622-2625
We recently reported that lithium ions induced an up-regulation of cysteine string protein (CSP) gene expression in nerve growth factor (NGF)-differentiated PC12 cells but not in undifferentiated cells. Concomitantly, expression of two other proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7068e7992aaaeb332be253ebbd9f050
https://doi.org/10.1046/j.1471-4159.2000.0752622.x
https://doi.org/10.1046/j.1471-4159.2000.0752622.x
Publikováno v:
Journal of Neurochemistry. 62:873-880
An antipeptide antiserum was raised against the C-terminal undecapeptide of a Torpedo cysteine-string protein (csp), a putative subunit or modulator of presynaptic calcium channels. This antiserum was shown to identify selectively the 27-kDa in vitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a574f0efa856c80a519546d51c6f520
https://doi.org/10.1046/j.1471-4159.1994.62030873.x
https://doi.org/10.1046/j.1471-4159.1994.62030873.x