Spreading of a virulence lipid into host membranes promotes mycobacterial pathogenesis

Autor: Cambier, CJ, Banik, Steven, Buonomo, Joseph A., Bertozzi, Carolyn

SUMMARY Several lipids of the pathogen Mycobacterium tuberculosis are known to promote virulence at various stages of disease. However, the inability to probe these lipids during in vivo infection makes elucidation of their pathogenic mechanisms diff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=sharebioRxiv::692cebf3e6dcd4f0caa669a79ab7185a

A Macrophage Response to Mycobacterium leprae Phenolic Glycolipid Initiates Nerve Damage in Leprosy

Autor: Ramakrishnan, L, Madigan, CA, Cambier, CJ, Kelly-Scumpia, KM, Scumpia, PO, Cheng, T-Y, Zailaa, J, Bloom, BR, Moody, DB, Smale, ST, Sagasti, A, Modlin, RL

$\textit{Mycobacterium leprae}$ causes leprosy and is unique among mycobacterial diseases in producing peripheral neuropathy. This debilitating morbidity is attributed to axon demyelination resulting from direct interaction of the $\textit{M. leprae}

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f342bdab937afca886fbec6ec49aebf8

Toward Point-of-Care Detection of Mycobacterium tuberculosis : A Brighter Solvatochromic Probe Detects Mycobacteria within Minutes.

Autor: Kamariza M; Department of Biology, Stanford University, Stanford, California 94305, United States., Keyser SGL; Department of Chemistry, University of California, Berkeley, Berkeley, California 94720, United States., Utz A; Department of Biology, Stanford University, Stanford, California 94305, United States., Knapp BD; Biophysics Program, Stanford University, Stanford, California 94305, United States., Ealand C; Department of Science and Technology/National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, Faculty of Health Sciences, University of Witwatersrand, National Health Laboratory Service, Johannesburg 2000, South Africa., Ahn G; Department of Chemistry, Stanford University, Stanford, California 94305, United States., Cambier CJ; Department of Chemistry, Stanford University, Stanford, California 94305, United States., Chen T; Department of Biology, Stanford University, Stanford, California 94305, United States., Kana B; Department of Science and Technology/National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, Faculty of Health Sciences, University of Witwatersrand, National Health Laboratory Service, Johannesburg 2000, South Africa.; Medical Research Council-Centre for the AIDS Programme of Research in South Africa (CAPRISA) HIV-TB Pathogenesis and Treatment Research Unit, Durban 4013, South Africa., Huang KC; Biophysics Program, Stanford University, Stanford, California 94305, United States.; Department of Bioengineering, Stanford University, Stanford, California 94305, United States.; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305, United States.; Chan Zuckerberg Biohub, San Francisco, California 94158, United States., Bertozzi CR; Department of Chemistry, University of California, Berkeley, Berkeley, California 94720, United States.; Department of Chemistry, Stanford University, Stanford, California 94305, United States.; Howard Hughes Medical Institute, Stanford University, Stanford, California 94305, United States.

Publikováno v: JACS Au [JACS Au] 2021 Jul 26; Vol. 1 (9), pp. 1368-1379. Date of Electronic Publication: 2021 Jul 26 (Print Publication: 2021).

Cyclopropane Modification of Trehalose Dimycolate Drives Granuloma Angiogenesis and Mycobacterial Growth through Vegf Signaling.

Autor: Walton EM; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA., Cronan MR; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA., Cambier CJ; Department of Chemistry, Stanford University, Stanford, CA 94305, USA., Rossi A; Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany., Marass M; Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany., Foglia MD; Department of Cell Biology, Duke University School of Medicine, Durham, NC 27710, USA; Regeneration Next, Duke University, Durham, NC 27710, USA., Brewer WJ; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA., Poss KD; Department of Cell Biology, Duke University School of Medicine, Durham, NC 27710, USA; Regeneration Next, Duke University, Durham, NC 27710, USA., Stainier DYR; Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany., Bertozzi CR; Department of Chemistry, Stanford University, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA., Tobin DM; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA; Department of Immunology, Duke University School of Medicine, Durham, NC 27710, USA. Electronic address: david.tobin@duke.edu.

Publikováno v: Cell host & microbe [Cell Host Microbe] 2018 Oct 10; Vol. 24 (4), pp. 514-525.e6.

A Macrophage Response to Mycobacterium leprae Phenolic Glycolipid Initiates Nerve Damage in Leprosy.

Autor: Madigan CA; Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Microbiology, University of Washington, Seattle, WA 98195, USA. Electronic address: cmadigan@ucla.edu., Cambier CJ; Department of Immunology, University of Washington, Seattle, WA 98195, USA., Kelly-Scumpia KM; Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA., Scumpia PO; Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA., Cheng TY; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Zailaa J; Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA., Bloom BR; Harvard School of Public Health, Boston, MA 02115, USA., Moody DB; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Smale ST; Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA., Sagasti A; Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA., Modlin RL; Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA., Ramakrishnan L; Department of Microbiology, University of Washington, Seattle, WA 98195, USA; Department of Immunology, University of Washington, Seattle, WA 98195, USA; Department of Medicine, University of Washington, Seattle, WA 98195, USA; MRC Laboratory of Molecular Biology, Molecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge CB2 OQH, UK. Electronic address: lr404@cam.ac.uk.

Publikováno v: Cell [Cell] 2017 Aug 24; Vol. 170 (5), pp. 973-985.e10.