Cardiac effect induced by Crotalus durissus cascavella venom: Morphofunctional evidence and mechanism of action.

Autor: Simões LO; Department of Bioregulation, Federal University of Bahia, Salvador, BA, 40110-902, Brazil., Alves QL; Department of Bioregulation, Federal University of Bahia, Salvador, BA, 40110-902, Brazil., Camargo SB; Department of Bioregulation, Federal University of Bahia, Salvador, BA, 40110-902, Brazil., Araújo FA; Department of Bioregulation, Federal University of Bahia, Salvador, BA, 40110-902, Brazil., Hora VRS; Department of Bioregulation, Federal University of Bahia, Salvador, BA, 40110-902, Brazil., Jesus RLC; Department of Bioregulation, Federal University of Bahia, Salvador, BA, 40110-902, Brazil., Barreto BC; Gonçalo Moniz Institute, FIOCRUZ, Salvador, BA, Brazil., Macambira SG; Gonçalo Moniz Institute, FIOCRUZ, Salvador, BA, Brazil; Department of Biochemistry and Biophysics, Federal University of Bahia, Salvador, BA, 40110-902, Brazil., Soares MBP; Gonçalo Moniz Institute, FIOCRUZ, Salvador, BA, Brazil., Meira CS; Gonçalo Moniz Institute, FIOCRUZ, Salvador, BA, Brazil., Aguiar MC; Department of Biomorphology, Institute of Health Sciences, Federal University of Bahia, Salvador, BA, 40110-902, Brazil., Couto RD; Department of Clinical and Toxicological Analysis, Federal University of Bahia, Salvador, BA, 41170290, Brazil., Lomonte B; Clodomiro Picado Institute, Faculty of Microbiology, University of Costa Rica, San José, 11501, Costa Rica., Menezes-Filho JE; Department of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, MG, 30161970, Brazil., Cruz JS; Department of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, MG, 30161970, Brazil., Vannier-Santos MA; Oswaldo Cruz Institute, Oswaldo Cruz Foundation - IOC-Fiocruz, Rio de Janeiro, Brazil., Casais-E-Silva LL; Department of Bioregulation, Federal University of Bahia, Salvador, BA, 40110-902, Brazil. Electronic address: luciana.casais@ufba.br., Silva DF; Department of Bioregulation, Federal University of Bahia, Salvador, BA, 40110-902, Brazil.

Publikováno v: Toxicology letters [Toxicol Lett] 2021 Feb 01; Vol. 337, pp. 121-133. Date of Electronic Publication: 2020 Nov 22.

Itaconimides derivatives induce relaxation in mesenteric artery and negative inotropism by inhibition of CA ²⁺ influx.

Autor: Moraes RDA; Laboratory of Cardiovascular Physiology and Pharmacology, Bioregulation Department, Federal University of Bahia (UFBA), Avenida Reitor Miguel Calmon, Vale do Canela, Salvador, BA, 40110-902, Brazil.; Gonçalo Moniz Institute, FIOCRUZ, Salvador, BA, Brazil., Alves QL; Laboratory of Cardiovascular Physiology and Pharmacology, Bioregulation Department, Federal University of Bahia (UFBA), Avenida Reitor Miguel Calmon, Vale do Canela, Salvador, BA, 40110-902, Brazil.; Gonçalo Moniz Institute, FIOCRUZ, Salvador, BA, Brazil., Camargo SB; Laboratory of Cardiovascular Physiology and Pharmacology, Bioregulation Department, Federal University of Bahia (UFBA), Avenida Reitor Miguel Calmon, Vale do Canela, Salvador, BA, 40110-902, Brazil.; Gonçalo Moniz Institute, FIOCRUZ, Salvador, BA, Brazil., Medeiros CFA; Laboratory of Cardiovascular Physiology and Pharmacology, Bioregulation Department, Federal University of Bahia (UFBA), Avenida Reitor Miguel Calmon, Vale do Canela, Salvador, BA, 40110-902, Brazil., Jesus AM; Laboratory of Cardiovascular Physiology and Pharmacology, Bioregulation Department, Federal University of Bahia (UFBA), Avenida Reitor Miguel Calmon, Vale do Canela, Salvador, BA, 40110-902, Brazil., da Hora VRS; Laboratory of Cardiovascular Physiology and Pharmacology, Bioregulation Department, Federal University of Bahia (UFBA), Avenida Reitor Miguel Calmon, Vale do Canela, Salvador, BA, 40110-902, Brazil., Stiz DS; Nucleus of Chemical-Pharmaceutical Investigations (NIQFAR), University of the Valley of Itajaí (UNIVALI), Itajaí, SC, Brazil., Corrêa R; Nucleus of Chemical-Pharmaceutical Investigations (NIQFAR), University of the Valley of Itajaí (UNIVALI), Itajaí, SC, Brazil., Cechinel-Filho V; Nucleus of Chemical-Pharmaceutical Investigations (NIQFAR), University of the Valley of Itajaí (UNIVALI), Itajaí, SC, Brazil., Silva DF; Laboratory of Cardiovascular Physiology and Pharmacology, Bioregulation Department, Federal University of Bahia (UFBA), Avenida Reitor Miguel Calmon, Vale do Canela, Salvador, BA, 40110-902, Brazil. darizy@gmail.com.; Gonçalo Moniz Institute, FIOCRUZ, Salvador, BA, Brazil. darizy@gmail.com.

Publikováno v: Pharmacological reports : PR [Pharmacol Rep] 2020 Aug; Vol. 72 (4), pp. 890-902. Date of Electronic Publication: 2020 Jan 23.