OS 21-03 EFFECTS OF THE TRPM7 KINASE DOMAIN IN VASCULAR DYSFUNCTION AND CARDIAC FIBROSIS INDUCED BY ALDOSTERONE AND SALT

Autor: Karla B Neves, Panagiota Anyfanti, Rhian M. Touyz, Livia L. Camargo Ll, Francisco J. Rios, Katie Y Hood, A. Karvey, Augusto C. Montezano, Ryszard Nosalski

Publikováno v: Journal of Hypertension. 34:e235-e236

TRPM7 is cation channel with intrinsic kinase activity important for cellular Mg2+ homeostasis. We recently showed that TRPM7-kinase plays a role in aldosterone-mediated vascular effects and inflammation. Here we explored the putative role of TRPM7-k

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https://doi.org/10.1097/01.hjh.0000500522.35716.8b

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Mechanisms of Vascular Inflammation and Potential Therapeutic Targets: A Position Paper From the ESH Working Group on Small Arteries.

Autor: Rios FJ; Research Institute of the McGill University Health Centre, McGill University, Montreal, Canada (F.J.R., L.L.C., A.C.M., R.M.T.)., de Ciuceis C; Department of Clinical and Experimental Sciences, University of Brescia (C.d.C., C.A.-R., D.R.)., Georgiopoulos G; Angiology and Endothelial Pathophysiology Unit, Department of Clinical Therapeutics, Medical School (G.G., G.M., K. Stamatelopoulos), National and Kapodistrian University of Athens., Lazaridis A; Third Department of Internal Medicine, Aristotle University of Thessaloniki, Papageorgiou Hospital, Greece (A.L., E.G.)., Nosalski R; Centre for Cardiovascular Sciences; Queen's Medical Research Institute, University of Edinburgh, United Kingdom (R.N., T.J.G.).; Department of Internal Medicine, Center for Medical Genomics OMICRON, Jagiellonian University Medical College, Krakow, Poland (R.N., T.J.G.)., Pavlidis G; Medical School (G.P., I.I.), National and Kapodistrian University of Athens.; Preventive Cardiology Laboratory and Clinic of Cardiometabolic Diseases, 2-Cardiology Department, Attikon Hospital, Athens, Greece (G.P., I.I.)., Tual-Chalot S; Biosciences Institute, Vascular Biology and Medicine Theme, Faculty of Medical Sciences, Newcastle University, United Kingdom (S.T.-C., K. Stellos)., Agabiti-Rosei C; Department of Clinical and Experimental Sciences, University of Brescia (C.d.C., C.A.-R., D.R.)., Camargo LL; Research Institute of the McGill University Health Centre, McGill University, Montreal, Canada (F.J.R., L.L.C., A.C.M., R.M.T.)., Dąbrowska E; Department of Hypertension and Diabetology, Center of Translational Medicine (E.D., J.W., K.N.) and M.D.)., Quarti-Trevano F; Clinica Medica, Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy (F.Q.-T., G.G.)., Hellmann M; Cardiac Diagnostics (M.H.), Medical University of Gdansk, Poland., Masi S; Institute of Cardiovascular Science, University College London, United Kingdom (S.M.).; Department of Clinical and Experimental Medicine, University of Pisa, Italy (S.M., M.L., A.M., S.T., A.V.)., Lopreiato M; Department of Clinical and Experimental Medicine, University of Pisa, Italy (S.M., M.L., A.M., S.T., A.V.)., Mavraganis G; Angiology and Endothelial Pathophysiology Unit, Department of Clinical Therapeutics, Medical School (G.G., G.M., K. Stamatelopoulos), National and Kapodistrian University of Athens., Mengozzi A; Department of Clinical and Experimental Medicine, University of Pisa, Italy (S.M., M.L., A.M., S.T., A.V.).; Center for Translational and Experimental Cardiology, Department of Cardiology, University Hospital Zurich, University of Zurich, Switzerland (A.M., F.P.).; Health Science Interdisciplinary Center, Scuola Superiore Sant'Anna, Pisa (A.M.)., Montezano AC; Research Institute of the McGill University Health Centre, McGill University, Montreal, Canada (F.J.R., L.L.C., A.C.M., R.M.T.)., Stavropoulos K; Second Medical Department, Hippokration Hospital, Aristotle University of Thessaloniki, Greece (K. Stavropoulos)., Winklewski PJ; Departments of Human Physiology (P.J.W.), Medical University of Gdansk, Poland., Wolf J; Department of Hypertension and Diabetology, Center of Translational Medicine (E.D., J.W., K.N.) and M.D.)., Costantino S; University Heart Center (S.C., F.P.), University Hospital Zurich, Switzerland., Doumas M; Department of Hypertension and Diabetology, Center of Translational Medicine (E.D., J.W., K.N.) and M.D.)., Gkaliagkousi E; Third Department of Internal Medicine, Aristotle University of Thessaloniki, Papageorgiou Hospital, Greece (A.L., E.G.)., Grassi G; Clinica Medica, Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy (F.Q.-T., G.G.)., Guzik TJ; Centre for Cardiovascular Sciences; Queen's Medical Research Institute, University of Edinburgh, United Kingdom (R.N., T.J.G.).; Department of Internal Medicine, Center for Medical Genomics OMICRON, Jagiellonian University Medical College, Krakow, Poland (R.N., T.J.G.)., Ikonomidis I; Medical School (G.P., I.I.), National and Kapodistrian University of Athens.; Preventive Cardiology Laboratory and Clinic of Cardiometabolic Diseases, 2-Cardiology Department, Attikon Hospital, Athens, Greece (G.P., I.I.)., Narkiewicz K; Department of Hypertension and Diabetology, Center of Translational Medicine (E.D., J.W., K.N.) and M.D.)., Paneni F; Center for Translational and Experimental Cardiology, Department of Cardiology, University Hospital Zurich, University of Zurich, Switzerland (A.M., F.P.).; University Heart Center (S.C., F.P.), University Hospital Zurich, Switzerland.; Department of Research and Education (F.P.), University Hospital Zurich, Switzerland., Rizzoni D; Department of Clinical and Experimental Sciences, University of Brescia (C.d.C., C.A.-R., D.R.).; Division of Medicine, Spedali Civili di Brescia, Italy (D.R.)., Stamatelopoulos K; Angiology and Endothelial Pathophysiology Unit, Department of Clinical Therapeutics, Medical School (G.G., G.M., K. Stamatelopoulos), National and Kapodistrian University of Athens., Stellos K; Biosciences Institute, Vascular Biology and Medicine Theme, Faculty of Medical Sciences, Newcastle University, United Kingdom (S.T.-C., K. Stellos).; Department of Cardiovascular Research, European Center for Angioscience, Medical Faculty Mannheim (K. Stellos), Heidelberg University, Germany.; Department of Cardiology, University Hospital Mannheim (K. Stellos), Heidelberg University, Germany.; German Centre for Cardiovascular Research, Heidelberg/Mannheim Partner Site (K. Stellos)., Taddei S; Department of Clinical and Experimental Medicine, University of Pisa, Italy (S.M., M.L., A.M., S.T., A.V.)., Touyz RM; Research Institute of the McGill University Health Centre, McGill University, Montreal, Canada (F.J.R., L.L.C., A.C.M., R.M.T.)., Virdis A; Department of Clinical and Experimental Medicine, University of Pisa, Italy (S.M., M.L., A.M., S.T., A.V.).

Publikováno v: Hypertension (Dallas, Tex. : 1979) [Hypertension] 2024 Jun; Vol. 81 (6), pp. 1218-1232. Date of Electronic Publication: 2024 Mar 21.

Oxidative Stress and Endoplasmic Reticular Stress Interplay in the Vasculopathy of Hypertension.

Autor: Camargo LL; Research Institute of the McGill University Health Centre, Montréal, Québec, Canada. Electronic address: livia.lucca@rimuhc.ca., Wang Y; School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, Scotland, United Kingdom., Rios FJ; Research Institute of the McGill University Health Centre, Montréal, Québec, Canada., McBride M; School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, Scotland, United Kingdom., Montezano AC; Research Institute of the McGill University Health Centre, Montréal, Québec, Canada., Touyz RM; Research Institute of the McGill University Health Centre, Montréal, Québec, Canada; McGill University, Department of Medicine and Department of Family Medicine, Montréal, Québec, Canada. Electronic address: rhian.touyz@mcgill.ca.

Publikováno v: The Canadian journal of cardiology [Can J Cardiol] 2023 Dec; Vol. 39 (12), pp. 1874-1887. Date of Electronic Publication: 2023 Oct 22.

The importance of microvascular inflammation in ageing and age-related diseases: a position paper from the ESH working group on small arteries, section of microvascular inflammation.

Autor: Mengozzi A; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.; Center for Translational and Experimental Cardiology (CTEC), Department of Cardiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.; Health Science Interdisciplinary Center, Scuola Superiore Sant'Anna, Pisa., de Ciuceis C; Department of Clinical and Experimental Sciences, University of Brescia, Brescia., Dell'oro R; Clinica Medica, Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy., Georgiopoulos G; Angiology and Endothelial Pathophysiology Unit, Department of Clinical Therapeutics, Medical School, National and Kapodistrian University of Athens, Athens., Lazaridis A; Third Department of Internal Medicine, Aristotle University of Thessaloniki, Papageorgiou Hospital, Thessaloniki, Greece., Nosalski R; Centre for Cardiovascular Sciences; Queen's Medical Research Institute; University of Edinburgh, University of Edinburgh, Edinburgh, UK.; Department of Internal Medicine.; Center for Medical Genomics OMICRON, Jagiellonian University Medical College, Krakow, Poland., Pavlidis G; Preventive Cardiology Laboratory and Clinic of Cardiometabolic Diseases, 2 Cardiology Department, Attikon Hospital, Athens.; Medical School, National and Kapodistrian University of Athens, Greece., Tual-Chalot S; Biosciences Institute, Vascular Biology and Medicine Theme, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, UK., Agabiti-Rosei C; Department of Clinical and Experimental Sciences, University of Brescia, Brescia., Anyfanti P; Second Medical Department, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece., Camargo LL; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.; Research Institute of the McGill University Health Centre (RI-MUHC), McGill University, Montreal, Canada., Dąbrowska E; Department of Hypertension and Diabetology, Center of Translational Medicine.; Center of Translational Medicine., Quarti-Trevano F; Clinica Medica, Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy., Hellmann M; Department of Cardiac Diagnostics, Medical University, Gdansk, Poland., Masi S; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.; Institute of Cardiovascular Science, University College London, London, UK., Mavraganis G; Angiology and Endothelial Pathophysiology Unit, Department of Clinical Therapeutics, Medical School, National and Kapodistrian University of Athens, Athens., Montezano AC; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.; Research Institute of the McGill University Health Centre (RI-MUHC), McGill University, Montreal, Canada., Rios FJ; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.; Research Institute of the McGill University Health Centre (RI-MUHC), McGill University, Montreal, Canada., Winklewski PJ; Department of Human Physiology, Medical University of Gdansk, Poland., Wolf J; Department of Hypertension and Diabetology, Center of Translational Medicine., Costantino S; Center for Translational and Experimental Cardiology (CTEC), Department of Cardiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.; University Heart Center, Cardiology, University Hospital Zurich., Gkaliagkousi E; Third Department of Internal Medicine, Aristotle University of Thessaloniki, Papageorgiou Hospital, Thessaloniki, Greece., Grassi G; Clinica Medica, Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy., Guzik TJ; Centre for Cardiovascular Sciences; Queen's Medical Research Institute; University of Edinburgh, University of Edinburgh, Edinburgh, UK.; Department of Internal Medicine.; Center for Medical Genomics OMICRON, Jagiellonian University Medical College, Krakow, Poland., Ikonomidis I; Preventive Cardiology Laboratory and Clinic of Cardiometabolic Diseases, 2 Cardiology Department, Attikon Hospital, Athens.; Medical School, National and Kapodistrian University of Athens, Greece., Narkiewicz K; Department of Hypertension and Diabetology, Center of Translational Medicine., Paneni F; Center for Translational and Experimental Cardiology (CTEC), Department of Cardiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.; University Heart Center, Cardiology, University Hospital Zurich.; Department of Research and Education, University Hospital Zurich, Zurich, Switzerland., Rizzoni D; Department of Clinical and Experimental Sciences, University of Brescia, Brescia.; Division of Medicine, Spedali Civili di Brescia, Montichiari, Brescia, Italy., Stamatelopoulos K; Angiology and Endothelial Pathophysiology Unit, Department of Clinical Therapeutics, Medical School, National and Kapodistrian University of Athens, Athens., Stellos K; Biosciences Institute, Vascular Biology and Medicine Theme, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, UK.; Department of Cardiovascular Research, European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University.; German Centre for Cardiovascular Research (Deutsches Zentrum für Herz-Kreislauf-Forschung, DZHK), Heidelberg/Mannheim Partner Site.; Department of Cardiology, University Hospital Mannheim, Heidelberg University, Manheim, Germany., Taddei S; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy., Touyz RM; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.; Research Institute of the McGill University Health Centre (RI-MUHC), McGill University, Montreal, Canada., Triantafyllou A; Third Department of Internal Medicine, Aristotle University of Thessaloniki, Papageorgiou Hospital, Thessaloniki, Greece., Virdis A; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

Publikováno v: Journal of hypertension [J Hypertens] 2023 Oct 01; Vol. 41 (10), pp. 1521-1543. Date of Electronic Publication: 2023 Jul 20.