Enhancing RECK Expression Through miR-21 Inhibition: A Promising Strategy for Bladder Carcinoma Control.

Autor: Dos Santos PRM; Laboratorio de Investigação Médica 55 (LIM55), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.; Faculdade de Medicina, Universidade Anhembi Morumbi, São Paulo, SP, Brazil., da Silva Gomes PR; Laboratorio de Investigação Médica 55 (LIM55), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.; Faculdade de Medicina, Universidade Federal do Pará, Belém, PA, Brazil., Romão P; Laboratorio de Investigação Médica 55 (LIM55), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil., Maluf FC; Laboratorio de Investigação Médica 55 (LIM55), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil., Guimarães VR; Laboratorio de Investigação Médica 55 (LIM55), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil., Candido P; Laboratorio de Investigação Médica 55 (LIM55), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.; Moriah Institute of Science and Education (MISE), Hospital Moriah, São Paulo, SP, Brazil., Gonçalves GL; Laboratory of Renal Physiology, Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil., de Camargo JA; Laboratorio de Investigação Médica 55 (LIM55), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil., Dos Santos GA; Laboratorio de Investigação Médica 55 (LIM55), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil., Silva I; Laboratorio de Investigação Médica 55 (LIM55), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil., Leite KRM; Laboratorio de Investigação Médica 55 (LIM55), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil., Nahas W; Uro-Oncology Group, Urology Department, University of Sao Paulo Medical School and Institute of Cancer Estate of Sao Paulo (ICESP), Sao Paulo, Brazil., Reis ST; Laboratorio de Investigação Médica 55 (LIM55), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.; Moriah Institute of Science and Education (MISE), Hospital Moriah, São Paulo, SP, Brazil., Pimenta R; Laboratorio de Investigação Médica 55 (LIM55), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.; D'Or Institute for Research and Education (IDOR), Sao Paulo, Brazil.; Precision Immunology Institute, Department of Immunology and Immunotherapy, and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, United States., Viana NI; Laboratorio de Investigação Médica 55 (LIM55), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil. niviana@usp.br.; Universidade do Estado de Minas Gerais - UEMG, Passos, MG, Brazil. niviana@usp.br.

Publikováno v: Biochemical genetics [Biochem Genet] 2024 Mar 24. Date of Electronic Publication: 2024 Mar 24.

MicroRNA-29b attenuates fibrosis in a rat model of Peyronie's disease.

Autor: Candido P; Urology Department, Laboratory of Medical Investigation (LIM55), Faculdade de Medicina da Universidade de São Paulo (FMUSP), Sao Paulo, Brazil.; Moriah Institute of Science and Education (MISE), Hospital Moriah, Sao Paulo, Brazil., Pimenta R; Urology Department, Laboratory of Medical Investigation (LIM55), Faculdade de Medicina da Universidade de São Paulo (FMUSP), Sao Paulo, Brazil.; Department of Immunology and Immunotherapy and Tisch Cancer Institute, Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Maluf FC; Urology Department, Laboratory of Medical Investigation (LIM55), Faculdade de Medicina da Universidade de São Paulo (FMUSP), Sao Paulo, Brazil.; Department of Urology, University of California San Francisco, San Francisco, California, USA., Chiovatto C; Urology Department, Laboratory of Medical Investigation (LIM55), Faculdade de Medicina da Universidade de São Paulo (FMUSP), Sao Paulo, Brazil.; Centro Universitário São Camilo, Sao Paulo, Brazil., Romão P; Urology Department, Laboratory of Medical Investigation (LIM55), Faculdade de Medicina da Universidade de São Paulo (FMUSP), Sao Paulo, Brazil., Baldavira CM; Department of Pathology, Faculdade de Medicina da Universidade de São Paulo (FMUSP), Sao Paulo, Brazil., Ghazarian V; Urology Department, Laboratory of Medical Investigation (LIM55), Faculdade de Medicina da Universidade de São Paulo (FMUSP), Sao Paulo, Brazil., Camargo JA; Urology Department, Laboratory of Medical Investigation (LIM55), Faculdade de Medicina da Universidade de São Paulo (FMUSP), Sao Paulo, Brazil., Guimarães VR; Urology Department, Laboratory of Medical Investigation (LIM55), Faculdade de Medicina da Universidade de São Paulo (FMUSP), Sao Paulo, Brazil., Santos GAD; Urology Department, Laboratory of Medical Investigation (LIM55), Faculdade de Medicina da Universidade de São Paulo (FMUSP), Sao Paulo, Brazil., Silva IA; Urology Department, Laboratory of Medical Investigation (LIM55), Faculdade de Medicina da Universidade de São Paulo (FMUSP), Sao Paulo, Brazil., Nascimento B; Division of Urology, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), Sao Paulo, Brazil., Hallak J; Division of Urology, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), Sao Paulo, Brazil., Capelozzi VL; Department of Pathology, Faculdade de Medicina da Universidade de São Paulo (FMUSP), Sao Paulo, Brazil., Srougi M; Urology Department, Laboratory of Medical Investigation (LIM55), Faculdade de Medicina da Universidade de São Paulo (FMUSP), Sao Paulo, Brazil.; Centro Universitário São Camilo, Sao Paulo, Brazil., Nahas WC; Urology Department, Uro-Oncology Group, University of São Paulo Medical School and Institute of Cancer Estate of São Paulo (ICESP), Sao Paulo, Brazil., Viana NI; Universidade do Estado de Minas Gerais - UEMG, Passos, Brazil., Leite KR; Urology Department, Laboratory of Medical Investigation (LIM55), Faculdade de Medicina da Universidade de São Paulo (FMUSP), Sao Paulo, Brazil., Reis ST; Urology Department, Laboratory of Medical Investigation (LIM55), Faculdade de Medicina da Universidade de São Paulo (FMUSP), Sao Paulo, Brazil.; Moriah Institute of Science and Education (MISE), Hospital Moriah, Sao Paulo, Brazil.

Publikováno v: Andrology [Andrology] 2024 Jun 24. Date of Electronic Publication: 2024 Jun 24.

Overexpression of miR-17-5p may negatively impact p300/CBP factor-associated inflammation in a hypercholesterolemic advanced prostate cancer model.

Autor: Pimenta R; Laboratorio de Investigação Médica 55 (LIM55), Faculdade de Medicina, Hospital das Clinicas HCFMUSP, Universidade de Sao Paulo, Av. Dr. Arnaldo 455, 2° floor, room 2145, Sao Paulo, Sao Paulo, SP, BR, SP, 01246- 903, Brazil. ruanpimenta22@gmail.com.; D'Or Institute for Research and Education (IDOR), Sao Paulo, Brazil. ruanpimenta22@gmail.com., Camargo JA; Laboratorio de Investigação Médica 55 (LIM55), Faculdade de Medicina, Hospital das Clinicas HCFMUSP, Universidade de Sao Paulo, Av. Dr. Arnaldo 455, 2° floor, room 2145, Sao Paulo, Sao Paulo, SP, BR, SP, 01246- 903, Brazil., Gonçalves GL; Laboratory of Renal Physiology, Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, 05508-000, Brazil., Ghazarian V; Laboratorio de Investigação Médica 55 (LIM55), Faculdade de Medicina, Hospital das Clinicas HCFMUSP, Universidade de Sao Paulo, Av. Dr. Arnaldo 455, 2° floor, room 2145, Sao Paulo, Sao Paulo, SP, BR, SP, 01246- 903, Brazil., Candido P; Laboratorio de Investigação Médica 55 (LIM55), Faculdade de Medicina, Hospital das Clinicas HCFMUSP, Universidade de Sao Paulo, Av. Dr. Arnaldo 455, 2° floor, room 2145, Sao Paulo, Sao Paulo, SP, BR, SP, 01246- 903, Brazil., Guimarães VR; Laboratorio de Investigação Médica 55 (LIM55), Faculdade de Medicina, Hospital das Clinicas HCFMUSP, Universidade de Sao Paulo, Av. Dr. Arnaldo 455, 2° floor, room 2145, Sao Paulo, Sao Paulo, SP, BR, SP, 01246- 903, Brazil., Romão P; Laboratorio de Investigação Médica 55 (LIM55), Faculdade de Medicina, Hospital das Clinicas HCFMUSP, Universidade de Sao Paulo, Av. Dr. Arnaldo 455, 2° floor, room 2145, Sao Paulo, Sao Paulo, SP, BR, SP, 01246- 903, Brazil., Chiovatto C; Laboratorio de Investigação Médica 55 (LIM55), Faculdade de Medicina, Hospital das Clinicas HCFMUSP, Universidade de Sao Paulo, Av. Dr. Arnaldo 455, 2° floor, room 2145, Sao Paulo, Sao Paulo, SP, BR, SP, 01246- 903, Brazil.; Centro Universitário São Camilo, São Paulo, 04263-200, Brazil., da Silva KS; Laboratorio de Investigação Médica 55 (LIM55), Faculdade de Medicina, Hospital das Clinicas HCFMUSP, Universidade de Sao Paulo, Av. Dr. Arnaldo 455, 2° floor, room 2145, Sao Paulo, Sao Paulo, SP, BR, SP, 01246- 903, Brazil.; Centro Universitário São Camilo, São Paulo, 04263-200, Brazil., Dos Santos GA; Laboratorio de Investigação Médica 55 (LIM55), Faculdade de Medicina, Hospital das Clinicas HCFMUSP, Universidade de Sao Paulo, Av. Dr. Arnaldo 455, 2° floor, room 2145, Sao Paulo, Sao Paulo, SP, BR, SP, 01246- 903, Brazil.; D'Or Institute for Research and Education (IDOR), Sao Paulo, Brazil., Silva IA; Laboratorio de Investigação Médica 55 (LIM55), Faculdade de Medicina, Hospital das Clinicas HCFMUSP, Universidade de Sao Paulo, Av. Dr. Arnaldo 455, 2° floor, room 2145, Sao Paulo, Sao Paulo, SP, BR, SP, 01246- 903, Brazil., Nahas WC; Uro-Oncology Group, Urology Department, University of Sao Paulo Medical School and Institute of Cancer Estate of Sao Paulo (ICESP), Sao Paulo, SP, 01246-000, Brazil., Leite KR; Laboratorio de Investigação Médica 55 (LIM55), Faculdade de Medicina, Hospital das Clinicas HCFMUSP, Universidade de Sao Paulo, Av. Dr. Arnaldo 455, 2° floor, room 2145, Sao Paulo, Sao Paulo, SP, BR, SP, 01246- 903, Brazil., Pessoa AFM; Natural Products and Derivatives Laboratory, Department of Surgery, University of São Paulo Medical School, São Paulo, SP, 01246-903, Brazil., Viana NI; Laboratorio de Investigação Médica 55 (LIM55), Faculdade de Medicina, Hospital das Clinicas HCFMUSP, Universidade de Sao Paulo, Av. Dr. Arnaldo 455, 2° floor, room 2145, Sao Paulo, Sao Paulo, SP, BR, SP, 01246- 903, Brazil.; Universidade do Estado de Minas Gerais - UEMG, Avenida Juca Stockler, Passos, MG, 1130, Brasil., Reis ST; Laboratorio de Investigação Médica 55 (LIM55), Faculdade de Medicina, Hospital das Clinicas HCFMUSP, Universidade de Sao Paulo, Av. Dr. Arnaldo 455, 2° floor, room 2145, Sao Paulo, Sao Paulo, SP, BR, SP, 01246- 903, Brazil.

Publikováno v: Molecular biology reports [Mol Biol Rep] 2023 Sep; Vol. 50 (9), pp. 7333-7345. Date of Electronic Publication: 2023 Jul 13.

The Effect of Gene Editing by CRISPR-Cas9 of miR-21 and the Indirect Target MMP9 in Metastatic Prostate Cancer.

Autor: Camargo JA; Laboratory of Medical Investigation (LIM 55), Urology Department, Medicine School, University of Sao Paulo (FMUSP), São Paulo 01246-903, SP, Brazil., Viana NI; Laboratory of Medical Investigation (LIM 55), Urology Department, Medicine School, University of Sao Paulo (FMUSP), São Paulo 01246-903, SP, Brazil.; Department of Bioscience, Minas Gerais State University (UEMG), Passos 37900-106, MG, Brazil., Pimenta R; Laboratory of Medical Investigation (LIM 55), Urology Department, Medicine School, University of Sao Paulo (FMUSP), São Paulo 01246-903, SP, Brazil.; D'Or Institute for Research and Education (ID'Or), São Paulo 04501-000, SP, Brazil., Guimarães VR; Laboratory of Medical Investigation (LIM 55), Urology Department, Medicine School, University of Sao Paulo (FMUSP), São Paulo 01246-903, SP, Brazil., Dos Santos GA; Laboratory of Medical Investigation (LIM 55), Urology Department, Medicine School, University of Sao Paulo (FMUSP), São Paulo 01246-903, SP, Brazil., Candido P; Laboratory of Medical Investigation (LIM 55), Urology Department, Medicine School, University of Sao Paulo (FMUSP), São Paulo 01246-903, SP, Brazil., Ghazarian V; Laboratory of Medical Investigation (LIM 55), Urology Department, Medicine School, University of Sao Paulo (FMUSP), São Paulo 01246-903, SP, Brazil., Romão P; Laboratory of Medical Investigation (LIM 55), Urology Department, Medicine School, University of Sao Paulo (FMUSP), São Paulo 01246-903, SP, Brazil., Silva IA; Laboratory of Medical Investigation (LIM 55), Urology Department, Medicine School, University of Sao Paulo (FMUSP), São Paulo 01246-903, SP, Brazil., Birbrair A; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte 30190-002, MG, Brazil.; Department of Dermatology, University of Wisconsin-Madison, Madison, WI 53715, USA.; Department of Radiology, Columbia University Medical Center, New York, NY 10032, USA., Srougi M; Laboratory of Medical Investigation (LIM 55), Urology Department, Medicine School, University of Sao Paulo (FMUSP), São Paulo 01246-903, SP, Brazil.; D'Or Institute for Research and Education (ID'Or), São Paulo 04501-000, SP, Brazil., Nahas WC; Uro-Oncology Group, Urology Department, University of São Paulo Medical School and Institute of Cancer Estate of São Paulo (ICESP), São Paulo 01246-000, SP, Brazil., Leite KR; Laboratory of Medical Investigation (LIM 55), Urology Department, Medicine School, University of Sao Paulo (FMUSP), São Paulo 01246-903, SP, Brazil., Trarbach EB; Laboratory of Cellular and Molecular Endocrinology (LIM25), Endocrinology Departament, Medicine School, University of São Paulo (FMUSP), São Paulo 01246-903, SP, Brazil., Reis ST; Laboratory of Medical Investigation (LIM 55), Urology Department, Medicine School, University of Sao Paulo (FMUSP), São Paulo 01246-903, SP, Brazil.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2023 Oct 03; Vol. 24 (19). Date of Electronic Publication: 2023 Oct 03.

Metformin acts in the gut and induces gut-liver crosstalk.

Autor: Tobar N; Department of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas, 13083-887 Brazil., Rocha GZ; Department of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas, 13083-887 Brazil., Santos A; Department of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas, 13083-887 Brazil., Guadagnini D; Department of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas, 13083-887 Brazil., Assalin HB; Department of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas, 13083-887 Brazil., Camargo JA; Department of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas, 13083-887 Brazil., Gonçalves AESS; Department of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas, 13083-887 Brazil., Pallis FR; Department of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas, 13083-887 Brazil., Oliveira AG; Department of Physical Education, São Paulo State University, Rio Claro, 13506-900 Brazil., Rocco SA; Brazilian Biosciences National Laboratory and Brazilian Center for Research in Energy and Materials, Campinas, 13083-100 Brazil., Neto RM; Brazilian Biosciences National Laboratory and Brazilian Center for Research in Energy and Materials, Campinas, 13083-100 Brazil., de Sousa IL; Brazilian Biosciences National Laboratory and Brazilian Center for Research in Energy and Materials, Campinas, 13083-100 Brazil., Alborghetti MR; Brazilian Biosciences National Laboratory and Brazilian Center for Research in Energy and Materials, Campinas, 13083-100 Brazil., Sforça ML; Brazilian Biosciences National Laboratory and Brazilian Center for Research in Energy and Materials, Campinas, 13083-100 Brazil., Rodrigues PB; Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, 13083-970 Brazil., Ludwig RG; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, São Paulo, 13083-970., Vanzela EC; Department of Structural and Functional Biology, University of Campinas, Campinas, 13083-865 Brazil., Brunetto SQ; Biomedical Engineering Center, University of Campinas, Campinas, 13083-881 Brazil., Boer PA; Department of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas, 13083-887 Brazil., Gontijo JAR; Department of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas, 13083-887 Brazil., Geloneze B; Department of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas, 13083-887 Brazil., Carvalho CRO; Institute Biomedical Sciences, University of Sao Paulo-Department of Physiology and Biophysics, São Paulo, 05508-000 Brazil., Prada PO; Department of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas, 13083-887 Brazil.; School of Applied Sciences, University of Campinas, Limeira, 13484-3501 Brazil., Folli F; Department of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas, 13083-887 Brazil., Curi R; Butantan Institute-São Paulo, 05503-900 Brazil., Mori MA; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, São Paulo, 13083-970., Vinolo MAR; Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, 13083-970 Brazil., Ramos CD; Division of Nuclear Medicine, Department of Radiology, School of Medical Sciences, University of Campinas, Campinas, 13083-888 Brazil., Franchini KG; Brazilian Biosciences National Laboratory and Brazilian Center for Research in Energy and Materials, Campinas, 13083-100 Brazil., Tormena CF; Institute of Chemistry, University of Campinas, Campinas, 13083-970 Brazil., Saad MJA; Department of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas, 13083-887 Brazil.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Jan 24; Vol. 120 (4), pp. e2211933120. Date of Electronic Publication: 2023 Jan 19.