A mild increase in nutrient signaling to mTORC1 in mice leads to parenchymal damage, myeloid inflammation and shortened lifespan.

Autor: Ortega-Molina A; Metabolism and Cell Signaling Laboratory, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. aortega@cbm.csic.es.; Metabolism in cancer and aging Laboratory, Immune System Development And Function Department, Centro de Biología Molecular Severo Ochoa (CBM), Madrid, Spain. aortega@cbm.csic.es., Lebrero-Fernández C; Metabolism and Cell Signaling Laboratory, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.; Metabolism in cancer and aging Laboratory, Immune System Development And Function Department, Centro de Biología Molecular Severo Ochoa (CBM), Madrid, Spain., Sanz A; Metabolism and Cell Signaling Laboratory, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Calvo-Rubio M; Translational Gerontology Branch, National Institute on Aging (NIA), National Institutes of Health (NIH), Baltimore, MD, USA., Deleyto-Seldas N; Metabolism and Cell Signaling Laboratory, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., de Prado-Rivas L; Metabolism and Cell Signaling Laboratory, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Plata-Gómez AB; Metabolism and Cell Signaling Laboratory, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Fernández-Florido E; Metabolism and Cell Signaling Laboratory, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., González-García P; Histopathology Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Vivas-García Y; Metabolism and Cell Signaling Laboratory, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Sánchez García E; Metabolism and Cell Signaling Laboratory, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Graña-Castro O; Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.; Institute of Applied Molecular Medicine (IMMA-Nemesio Díez), Department of Basic Medical Sciences, School of Medicine, San Pablo-CEU University, CEU Universities, Boadilla del Monte, Madrid, Spain., Price NL; Translational Gerontology Branch, National Institute on Aging (NIA), National Institutes of Health (NIH), Baltimore, MD, USA., Aroca-Crevillén A; Cardiovascular Regeneration Program, Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain., Caleiras E; Histopathology Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Monleón D; Department of Pathology, University of Valencia, Valencia, Spain; Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable-Instituto de Salud Carlos III (CIBERFES-ISCIII), Institute of Health Research-INCLIVA, Valencia, Spain., Borrás C; Freshage Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable-Instituto de Salud Carlos III (CIBERFES-ISCIII), MiniAging Research Group, Institute of Health Research-INCLIVA, Valencia, Spain., Casanova-Acebes M; Cancer Immunity Laboratory, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., de Cabo R; Translational Gerontology Branch, National Institute on Aging (NIA), National Institutes of Health (NIH), Baltimore, MD, USA., Efeyan A; Metabolism and Cell Signaling Laboratory, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. aefeyan@cnio.es.

Publikováno v: Nature aging [Nat Aging] 2024 Aug; Vol. 4 (8), pp. 1102-1120. Date of Electronic Publication: 2024 Jun 07.

The YAP-TEAD complex promotes senescent cell survival by lowering endoplasmic reticulum stress.

Autor: Anerillas C; Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA. carlos.anerillasaljama@nih.gov., Mazan-Mamczarz K; Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Herman AB; Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Munk R; Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Lam KG; Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Calvo-Rubio M; Translational Gerontology Branch, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD, USA., Garrido A; Translational Gerontology Branch, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD, USA., Tsitsipatis D; Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Martindale JL; Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Altés G; Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Rossi M; Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Piao Y; Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Fan J; Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Cui CY; Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., De S; Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Abdelmohsen K; Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., de Cabo R; Translational Gerontology Branch, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD, USA., Gorospe M; Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA. myriam-gorospe@nih.gov.

Publikováno v: Nature aging [Nat Aging] 2023 Oct; Vol. 3 (10), pp. 1237-1250. Date of Electronic Publication: 2023 Sep 04.

Overexpression of CYB5R3 and NQO1, two NAD(+)-producing enzymes, mimics aspects of caloric restriction

Autor: Diaz-Ruiz A, Lanasa M, Garcia J, Mora H, Fan F, Martin-Montalvo A, Di Francesco A, Calvo-Rubio M, Salvador-Pascual A, Aon M, Fishbein K, Pearson K, Villalba J, Navas P, Bernier M, de Cabo R

Publikováno v: AGING CELL
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
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Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::2d8fe46656e1a2b77629abbe81f58ba0
https://www.fundanet.incliva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=1669

Mitochondrial health is enhanced in rats with higher vs. lower intrinsic exercise capacity and extended lifespan.

Autor: Aon MA; Laboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD, 21224, USA. miguel.aon@nih.gov.; Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD, 21224, USA. miguel.aon@nih.gov., Cortassa S; Laboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD, 21224, USA., Juhaszova M; Laboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD, 21224, USA., González-Reyes JA; Departamento de Biología Celular, Fisiología e Inmunología, Campus de Excelencia Internacional Agroalimentario, ceiA3, Universidad de Córdoba, Córdoba, Spain., Calvo-Rubio M; Departamento de Biología Celular, Fisiología e Inmunología, Campus de Excelencia Internacional Agroalimentario, ceiA3, Universidad de Córdoba, Córdoba, Spain., Villalba JM; Departamento de Biología Celular, Fisiología e Inmunología, Campus de Excelencia Internacional Agroalimentario, ceiA3, Universidad de Córdoba, Córdoba, Spain., Lachance AD; Laboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD, 21224, USA., Ziman BD; Laboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD, 21224, USA., Mitchell SJ; Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD, 21224, USA.; Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA., Murt KN; Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD, 21224, USA., Axsom JEC; Laboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD, 21224, USA., Alfaras I; Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD, 21224, USA.; Department of Medicine, Aging Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Britton SL; Department of Anesthesiology, University of Michigan, Ann Arbor, MI, USA.; Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Koch LG; Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA., de Cabo R; Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD, 21224, USA., Lakatta EG; Laboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD, 21224, USA., Sollott SJ; Laboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD, 21224, USA. SollottS@grc.nia.nih.gov.

Publikováno v: NPJ aging and mechanisms of disease [NPJ Aging Mech Dis] 2021 Jan 04; Vol. 7 (1), pp. 1. Date of Electronic Publication: 2021 Jan 04.

Growth hormone‐releasing hormone deficiency confers extended lifespan and metabolic resilience during high‐fat feeding in mid and late life.

Autor: Adkins‐Jablonsky, Joseph¹ (AUTHOR), Lasher, Alexander Tate¹ (AUTHOR), Patki, Amit² (AUTHOR), Nagarajan, Akash¹ (AUTHOR), Sun, Liou Y.¹ (AUTHOR) sunlab@uab.edu

Publikováno v: Aging Cell. Sep2024, Vol. 23 Issue 9, p1-14. 14p.