Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Calvin Yee"'
Autor:
Alexey Dementiev, Abel Silva, Calvin Yee, Zhe Li, Michael T. Flavin, Hing Sham, James R. Partridge
Publikováno v:
Blood Advances, Vol 2, Iss 5, Pp 549-558 (2018)
Abstract: Activated factor XIIa (FXIIa) is a serine protease that has received a great deal of interest in recent years as a potential target for the development of new antithrombotics. Despite the strong interest in obtaining structural information,
Externí odkaz:
https://doaj.org/article/7129089a7ea744118c8a866d33651f42
Autor:
Calvin Yee Keen Lau, Fang-Fang Chua
Publikováno v:
Proceedings of the International Conference on Computer, Information Technology and Intelligent Computing (CITIC 2022) ISBN: 9789464630930
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa1a12d97a695796c9911ffc7bf416ec
https://doi.org/10.2991/978-94-6463-094-7_14
https://doi.org/10.2991/978-94-6463-094-7_14
Akademický článek
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Autor:
Audry K Nishi, Tina Jeoh, Julian M. Lopez, Kyria Boundy-Mills, Nardrapee Karuna, Alex Hitomi, David E. Block, L Antonio Garay, Calvin Yee, Lauren L. Enriquez, Christopher C. Roberts
Publikováno v:
Journal of the science of food and agriculture. 99(6)
Background Cassava leaves are an abundant global agricultural residue because the roots are a major source of dietary carbohydrates. Although cassava leaves are high in protein, the protein is not bioavailable. This work aimed to convert cassava leav
Autor:
Athiwat Hutchaleelaha, Harris Jason R, Qing Xu, Donna Oksenberg, Matthew P. Jacobson, Carl Johnson, Larysa N. Patskovska, Zhe Li, Joyce James, Qing Lu, Paulvannan Kumar, Chihyuan Chuang, Donghong Xu, Yury Patskovsky, Lan Hua, Abel Silva-Garcia, Kobina Dufu, Brian Metcalf, Bradley P Morgan, James R. Partridge, Stephen L Gwaltney, Calvin Yee, Mira Patel, Steven C. Almo
We report the discovery of a new potent allosteric effector of sickle cell hemoglobin, GBT440 (36), that increases the affinity of hemoglobin for oxygen and consequently inhibits its polymerization when subjected to hypoxic conditions. Unlike earlier
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::474bb23099c36d4a59ac8cad2e76a0d7
https://europepmc.org/articles/PMC5346980/
https://europepmc.org/articles/PMC5346980/
Autor:
Andreas Kuglstatter, Allen John Lovey, Minh Diem Vu, John Menke, Parcharee Tivitmahaisoon, Douglas Roy, Vaishali Patel, Michael Soth, Javier DeVicente, Sue Jin, Linghao Niu, Stephen M. Lynch, Hongju Li, Calvin Yee, Saul Jaime-Figueroa, Johannes C. Hermann, Sandra Steiner
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:2793-2800
Using a structure based design approach we have identified a series of indazole substituted pyrrolopyrazines, which are potent inhibitors of JAK3. Intramolecular electronic repulsion was used as a strategy to induce a strong conformational bias withi
Autor:
Matthew C. Lucas, Gisele A. Tavares, Deborah Carol Reuter, Nidhi Arora, Amy Fung, Sophie Le Pogam, Vincent Leveque, Hanbiao Yang, Yanli Yang, Dov Nitzan, Robert Than Hendricks, Calvin Yee, Julie Q. Hang, Sonal Rajyaguru, Seth F. Harris
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:4614-4619
Conformational modeling has been successfully applied to the design of cyclic bioisosteres used to replace a conformationally rigid amide bond in a series of thiophene carboxylate inhibitors of HCV NS5B polymerase. Select compounds were equipotent wi
Autor:
Vincent Leveque, Gloria Ao-Ieong, Sophie Le Pogam, Bamberg Joe Timothy, Javier de Vicente, Stengel Peter J, Stacey Renee Spencer, John P. Fischer, Todd R. Elworthy, Andrew J. Briggs, Jim Li, Peter Mohr, Michael Brandl, Sunil Sukhtankar, Ramona Hilgenkamp, Calvin Yee, Ludmila Alexandrova, Robinson John E, Fell Jay Bradford, Beihan Wang, April Wong, Robert Than Hendricks, Farrell Robert P, Isabel Najera, David Bernard Smith, Seth F. Harris, Sonal Rajyaguru, Susan Larrabee, James F. Blake, George Adjabeng
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5652-5656
A series of benzo[d]isothiazole-1,1-dioxides were designed and evaluated as inhibitors of HCV polymerase NS5B. Structure-based design led to the incorporation of a high affinity methyl sulfonamide group. Structure-activity relationship (SAR) studies
Autor:
Elbert Chin, Manjiri Ghate, Vincent Leveque, Sonal Rajyaguru, Bill Fitch, Jahari Laurant Tracy, Michael Brandl, Steve A. de Keczer, Ramona Hilgenkamp, Fell Jay Bradford, Tatyana Voronin, Isabel Najera, Gloria Ao-Ieong, Javier de Vicente, Shao-Yong Wu, Beihan Wang, Stacey Renee Spencer, Stengel Peter J, Peter Mohr, Mohammad R. Masjedizadeh, James F. Blake, Robert Than Hendricks, Todd R. Elworthy, David Bernard Smith, Junping Zhao, Ludmila Alexandrova, Robinson John E, Al Lui, John P. Fischer, Seth F. Harris, Jim Li, Connie Oshiro, Calvin Yee, Sophie Le Pogam
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5648-5651
Benzothiazine-substituted tetramic acids were discovered as highly potent non-nucleoside inhibitors of HCV NS5B polymerase. X-ray crystallography studies confirmed the binding mode of these inhibitors with HCV NS5B polymerase. Rational optimization o
Autor:
Ludmila Alexandrova, Connie Oshiro, Ramona Hilgenkamp, Stengel Peter J, Isabel Najera, Peter Mohr, Jahari Laurant Tracy, Susan Larrabee, James F. Blake, David Bernard Smith, Bamberg Joe Timothy, George Adjabeng, Vincent Leveque, Andrew J. Briggs, Brian Xu, Seth F. Harris, Rebecca A. Stephenson, Sonal Rajyaguru, Manjiri Ghate, Beihan Wang, John P. Fischer, Stacey Renee Spencer, Calvin Yee, Sophie Le Pogam, Elbert Chin, Michael Brandl, Fell Jay Bradford, Gloria Ao-Ieong, Sunil Sukhtankar, Robert Than Hendricks, Jim Li, Robinson John E, Todd R. Elworthy, Farrell Robert P, Javier de Vicente
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:3642-3646
A new series of benzothiazine-substituted quinolinediones were evaluated as inhibitors of HCV polymerase NS5B. SAR studies on this series revealed a methyl sulfonamide group as a high affinity feature. Analogues with this group showed submicromolar p