Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Calvin S. Leung"'
Autor:
Calvin S. Leung, Oksana Kosyk, Emma M. Welter, Nicholas Dietrich, Trevor K. Archer, Anthony S. Zannas
Publikováno v:
iScience, Vol 25, Iss 9, Pp 104960- (2022)
Summary: Chronic environmental stress can profoundly impact cell and body function. Although the underlying mechanisms are poorly understood, epigenetics has emerged as a key link between environment and health. The genomic effects of stress are thou
Externí odkaz:
https://doaj.org/article/7ec769d869d247528f5def784a303706
Autor:
Calvin S. Leung, Stephen M. Douglass, Marco Morselli, Matthew B. Obusan, Marat S. Pavlyukov, Matteo Pellegrini, Tracy L. Johnson
Publikováno v:
Cell Reports, Vol 27, Iss 13, Pp 3760-3769.e4 (2019)
Summary: In the eukaryotic cell, spliceosomes assemble onto pre-mRNA cotranscriptionally. Spliceosome assembly takes place in the context of the chromatin environment, suggesting that the state of the chromatin may affect splicing. The molecular deta
Externí odkaz:
https://doaj.org/article/d857ada9fe6d4786934eb935f9a0b8a4
Publikováno v:
Genes, Vol 11, Iss 12, p 1425 (2020)
Psychosocial stress, especially when chronic or excessive, can increase disease risk and accelerate biological aging. Although the underlying mechanisms are unclear, in vivo studies have associated exposure to stress and glucocorticoid stress hormone
Externí odkaz:
https://doaj.org/article/c74638364b094fa4a583a6e6f54b3155
Autor:
Calvin S Leung, Shoshana J Rosenzweig, Brian Yoon, Nicholas A Marinelli, Ethan W Hollingsworth, Abbie M Maguire, Mara H Cowen, Michael Schmidt, Jaime Imitola, Ece D Gamsiz Uzun, Sofia B Lizarraga
Autism spectrum disorder (ASD) affects 1 in 44 children. Chromatin regulatory proteins are overrepresented among genes that contain high risk variants in ASD. Disruption of the chromatin environment leads to widespread dysregulation of gene expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea677a9947fd6b29fc4c1485b2e3b6ad
https://doi.org/10.1101/2022.09.08.507162
https://doi.org/10.1101/2022.09.08.507162
Autor:
Calvin S. Leung, Oksana Kosyk, Emma M. Welter, Nicholas Dietrich, Trevor K. Archer, Anthony S. Zannas
Publikováno v:
SSRN Electronic Journal.
Publikováno v:
Genes
Genes, Vol 11, Iss 1425, p 1425 (2020)
Genes, Vol 11, Iss 1425, p 1425 (2020)
Psychosocial stress, especially when chronic or excessive, can increase disease risk and accelerate biological aging. Although the underlying mechanisms are unclear, in vivo studies have associated exposure to stress and glucocorticoid stress hormone
Autor:
Jie Zhou, Jake Cozy, Charlotte A. Nelson, Harry F. Noller, Gillian Rexroad, Calvin S. Leung, Laura Lancaster, Dustin Niblett
Publikováno v:
RNA
A recent crystal structure of a ribosome complex undergoing partial translocation in the absence of elongation factor EF-G showed disruption of codon–anticodon pairing and slippage of the reading frame by −1, directly implicating EF-G in preserva
Pre-mRNA splicing is vital for the proper function and regulation of eukaryotic gene expression. Saccharomyces cerevisiae has been used as a model organism for studies of RNA splicing because of the striking conservation of the spliceosome components
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90dcf2db15b58842c98bfe89e31a5123
Autor:
Tracy L. Johnson, Calvin S. Leung
Publikováno v:
Molecular cell, vol 72, iss 5
Productive splicing of human precursor messenger RNAs (pre-mRNAs) requires the correct selection of authentic splice sites (SS) from the large pool of potential SS. Although SS consensus sequence and splicing regulatory proteins are known to influenc
Autor:
Marco Morselli, Stephen Douglass, Matteo Pellegrini, Tracy L. Johnson, Calvin S. Leung, Marat S. Pavlyukov, Matthew B. Obusan
Publikováno v:
Cell reports
Cell Reports, Vol 27, Iss 13, Pp 3760-3769.e4 (2019)
Cell Reports, Vol 27, Iss 13, Pp 3760-3769.e4 (2019)
SUMMARY In the eukaryotic cell, spliceosomes assemble onto pre-mRNA cotranscriptionally. Spliceosome assembly takes place in the context of the chromatin environment, suggesting that the state of the chromatin may affect splicing. The molecular detai