Výsledky vyhledávání - "Calvin R Jerde"

Akademický článek

Limited Correlation between SARS-CoV-2 Serologic Assays for Identification of High-Titer COVID-19 Convalescent Plasma Using FDA Thresholds

Autor: Nicholas E. Larkey, Radwa Ewaisha, Michael A. Lasho, Matthew M. Roforth, Dane Granger, Calvin R. Jerde, Liang Wu, Amy Gorsh, Stephen A. Klassen, Jonathon W. Senefeld, Michael J. Joyner, Nikola A. Baumann, Elitza S. Theel, John R. Mills

Publikováno v: Microbiology Spectrum, Vol 10, Iss 4 (2022)

ABSTRACT In August 2020, the Food and Drug Administration (FDA) Emergency Use Authorization (EUA) for COVID-19 convalescent plasma (CCP) specified 12 authorized serologic assays and associated assay-specific cutoff values for the selection of high-ti

Externí odkaz: https://doaj.org/article/35c62f308af6425585d0f305f02cad5a

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Data from Histone H3K27 Trimethylation Modulates 5-Fluorouracil Resistance by Inhibiting PU.1 Binding to the DPYD Promoter

Autor: Robert B. Diasio, Steven M. Offer, Tarig A. Elraiyah, Shikshya Shrestha, Garrett S. Dunlap, Calvin R. Jerde, Erin E. Tapper, Qian Nie, Rentian Wu

The antimetabolite 5-fluorouracil (5-FU) is one of the most widely used chemotherapy drugs. Dihydropyrimidine dehydrogenase (DPD) is a major determinant of 5-FU response and toxicity. Although DPYD variants may affect 5-FU metabolism, they do not com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c4079b598d1e5755293fa849a9aaca91
https://doi.org/10.1158/0008-5472.c.6508592.v1

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Supplementary Figures S1-S6 from Histone H3K27 Trimethylation Modulates 5-Fluorouracil Resistance by Inhibiting PU.1 Binding to the DPYD Promoter

Autor: Robert B. Diasio, Steven M. Offer, Tarig A. Elraiyah, Shikshya Shrestha, Garrett S. Dunlap, Calvin R. Jerde, Erin E. Tapper, Qian Nie, Rentian Wu

Relationship between DPYD and EZH2 expression (S1); Inhibition of Ezh2 results in increased DPYD expression and desensitizes cells to 5-FU (S2); H3K27me3 demethylases UTX and Jmjd3 expression in various tissues (S3); H3K27 trimethylation prevented PU

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33e96baacb6e85db5e481c6f8f717413
https://doi.org/10.1158/0008-5472.22413032

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Targeted Detection of SARS-CoV-2 Nucleocapsid Sequence Variants by Mass Spectrometric Analysis of Tryptic Peptides

Autor: Stefan K.G. Grebe, Ravinder J. Singh, Benjamin R. Kipp, Jennifer V. Kemp, Joseph H. Blommel, Surendra Dasari, Santosh Renuse, Anthony D. Maus, Anil K. Madugundu, Calvin R. Jerde, Patrick M. Vanderboom, Akhilesh Pandey

Publikováno v: Journal of Proteome Research

COVID-19 vaccines are becoming more widely available, but accurate and rapid testing remains a crucial tool for slowing the spread of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus. Although the quantitative reverse transcript

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6cc1d1b104dd6ad0dd444edc9d17176
https://pubmed.ncbi.nlm.nih.gov/34779632

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SARS-CoV-2 Serologic Assays Dependent on Dual-Antigen Binding Demonstrate Diverging Kinetics Relative to Other Antibody Detection Methods

Autor: Brenna M Murphy, John R. Mills, Michael J. Joyner, Michael Lasho, Katie L. Kunze, Rickey E. Carter, Julie Harring, Jonathon W Senefeld, Calvin R Jerde, Kylie J Andersen, Patrick W. Johnson, Nikola A Baumann, Liang Wu, Dane Granger, Sergei A. Svarovsky, Amy P Gorsh, Matthew M. Roforth, Douglas F. Lake, Elitza S. Theel

Publikováno v: Journal of Clinical Microbiology

Longitudinal studies assessing durability of the anti-severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2) humoral immune response have generated conflicting results. This has been proposed to be due to differences in patient populations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bf6b9c0032e292af4bf6da66aea3d29
https://pubmed.ncbi.nlm.nih.gov/34166066

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Gene-Specific Variant Classifier (DPYD-Varifier) to Identify Deleterious Alleles of Dihydropyrimidine Dehydrogenase

Autor: Cheng Zhang, Shikshya Shrestha, Hu Li, Calvin R. Jerde, Qian Nie, Robert B. Diasio, Steven M. Offer

Publikováno v: Clinical Pharmacology & Therapeutics. 104:709-718

Deleterious variants in dihydropyrimidine dehydrogenase (DPD, DPYD gene) can be highly predictive of clinical toxicity to the widely prescribed chemotherapeutic 5-fluorouracil (5-FU). However, there is very limited data pertaining to the functional c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bad25cc2d82a10499b294561d6f773b0
https://doi.org/10.1002/cpt.1020

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Novel Deleterious Dihydropyrimidine Dehydrogenase Variants May Contribute to 5-Fluorouracil Sensitivity in an East African Population

Autor: Nasra H. Giama, Tarig Elraiyah, Calvin R. Jerde, Lewis R. Roberts, Qian Nie, Vivekananda Sarangi, Robert B. Diasio, Rentian Wu, Steven M. Offer, Shikshya Shrestha

Publikováno v: Clinical Pharmacology & Therapeutics. 101:382-390

Clinical studies have identified specific genetic variants in dihydropyrimidine dehydrogenase (DPD; DPYD gene) as predictors of severe adverse toxicity to the commonly used chemotherapeutic 5-fluorouracil (5-FU); however, these studies have focused o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::720e7e7a89b8bf4206cb95c48dc9e716
https://doi.org/10.1002/cpt.531

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