Zobrazeno 1 - 10
of 217
pro vyhledávání: '"Calvin Lee"'
Autor:
Rong Deng, Leonid Gibiansky, Tong Lu, Christopher R. Flowers, Laurie H. Sehn, Qi Liu, Priya Agarwal, Michael Z. Liao, Randall Dere, Calvin Lee, Gabriel Man, Jamie Hirata, Chunze Li, Dale Miles
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 6, Pp 1055-1066 (2024)
Abstract Polatuzumab vedotin is a CD79b‐directed antibody–drug conjugate that targets B cells and delivers the cytotoxic payload monomethyl auristatin E (MMAE). The phase III POLARIX study (NCT03274492) evaluated polatuzumab vedotin in combinatio
Externí odkaz:
https://doaj.org/article/94a1657630df4f2992ff53a1a61eb869
Autor:
Michael Z. Liao, Rong Deng, Leonid Gibiansky, Tong Lu, Priya Agarwal, Randall Dere, Calvin Lee, Jamie Hirata, Charles Herbaux, Gilles Salles, Chunze Li, Dale Miles
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 12, Pp 2744-2755 (2023)
Abstract This ethnic sensitivity analysis used data from the phase III POLARIX study (NCT03274492) to assess polatuzumab vedotin pharmacokinetics (PKs) in Asian versus non‐Asian patients with previously untreated diffuse large B‐cell lymphoma and
Externí odkaz:
https://doaj.org/article/8694ec4d77c146a69f093aef77194270
Autor:
Sandra Sanchez-Roige, Mariela V. Jennings, Hayley H. A. Thorpe, Jazlene E. Mallari, Lieke C. van der Werf, Sevim B. Bianchi, Yuye Huang, Calvin Lee, Travis T. Mallard, Samuel A. Barnes, Jin Yi Wu, Amanda M. Barkley-Levenson, Ely C. Boussaty, Cedric E. Snethlage, Danielle Schafer, Zeljana Babic, Boyer D. Winters, Katherine E. Watters, Thomas Biederer, andMe Research Team, James Mackillop, David N. Stephens, Sarah L. Elson, Pierre Fontanillas, Jibran Y. Khokhar, Jared W. Young, Abraham A. Palmer
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Impulsivity is a multidimensional heritable phenotype that broadly refers to the tendency to act prematurely and is associated with multiple forms of psychopathology, including substance use disorders. We performed genome-wide association st
Externí odkaz:
https://doaj.org/article/b47ec1bf7cc04d37956dc97a36fdfe9e
Publikováno v:
CJC Open, Vol 4, Iss 11, Pp 939-945 (2022)
Background: The Apple Watch Series 4 (AW4) and the KardiaMobile single bipolar lead model (KM) are 2 of the most popular US Food & Drug Administration (FDA)-approved commercial heart trackers. However, a lack of knowledge remains regarding their rhyt
Externí odkaz:
https://doaj.org/article/6c0f2ce1c2bd4d65b1d78be1d746fbb4
Autor:
Lale Kostakoglu, Federico Dalmasso, Paola Berchialla, Larry A. Pierce, Umberto Vitolo, Maurizio Martelli, Laurie H. Sehn, Marek Trněný, Tina G. Nielsen, Christopher R. Bolen, Deniz Sahin, Calvin Lee, Tarec Christoffer El‐Galaly, Federico Mattiello, Paul E. Kinahan, Stephane Chauvie
Publikováno v:
eJHaem, Vol 3, Iss 2, Pp 406-414 (2022)
Abstract Image texture analysis (radiomics) uses radiographic images to quantify characteristics that may identify tumour heterogeneity and associated patient outcomes. Using fluoro‐deoxy‐glucose positron emission tomography/computed tomography (
Externí odkaz:
https://doaj.org/article/b8bbe56c53944bd0a888cd8d151c81e5
Publikováno v:
Materials, Vol 16, Iss 12, p 4291 (2023)
Flip Chip Ball Grid Array (FCBGA) packages, together with many other heterogeneous integration packages, are widely used in high I/O (Input/Output) density and high-performance computing applications. The thermal dissipation efficiency of such packag
Externí odkaz:
https://doaj.org/article/503ee46c185d46d9af420d4b23b79ac7
Autor:
Sowmya Pattabhi, Samantha N. Lotti, Mason P. Berger, Swati Singh, Christopher T. Lux, Kyle Jacoby, Calvin Lee, Olivier Negre, Andrew M. Scharenberg, David J. Rawlings
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 17, Iss , Pp 277-288 (2019)
Gene editing following designer nuclease cleavage in the presence of a DNA donor template can revert mutations in disease-causing genes. For optimal benefit, reversion of the point mutation in HBB leading to sickle cell disease (SCD) would permit pre
Externí odkaz:
https://doaj.org/article/5c5d0cc4529c44adb9273c8f4a9f26d9
Autor:
Nichol S. Martinez, Sumant Inamdar, Sheila N. Firoozan, Stephanie Izard, Calvin Lee, Petros C. Benias, Arvind J. Trindade, Divyesh V. Sejpal
Publikováno v:
Endoscopy International Open, Vol 09, Iss 06, Pp E888-E894 (2021)
Background and study aims There are conflicting data regarding the risk of post-ERCP pancreatitis (PEP) with self-expandable metallic stents (SEMS) compared to polyethylene stents (PS) in malignant biliary obstructions and limited data related to ben
Externí odkaz:
https://doaj.org/article/ce4165d13013415fb1dd4ae25cc56123
Autor:
Christopher T. Lux, Sowmya Pattabhi, Mason Berger, Cynthia Nourigat, David A. Flowers, Olivier Negre, Olivier Humbert, Julia G. Yang, Calvin Lee, Kyle Jacoby, Irwin Bernstein, Hans-Peter Kiem, Andrew Scharenberg, David J. Rawlings
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 12, Iss , Pp 175-183 (2019)
Elements within the γ-hemoglobin promoters (HBG1 and HBG2) function to bind transcription complexes that mediate repression of fetal hemoglobin expression. Sickle cell disease (SCD) subjects with a 13-bp deletion in the HBG1 promoter exhibit a clini
Externí odkaz:
https://doaj.org/article/d1669924b97e44a4beafad9d2ebc6f23
Autor:
Michael Fenlon, Celia Short, Jiabo Xu, Nicolas Malkoff, Elaa Mahdi, Michelle Hough, Alison Glazier, Calvin Lee, Kinji Asahina, Kasper S. Wang
Publikováno v:
Physiological Reports, Vol 8, Iss 14, Pp n/a-n/a (2020)
Abstract Cholestatic liver injury is associated with intrahepatic biliary fibrosis, which can progress to cirrhosis. Resident hepatic progenitor cells (HPCs) expressing Prominin‐1 (Prom1 or CD133) become activated and participate in the expansion o
Externí odkaz:
https://doaj.org/article/53d2a788a1054b1bbc240ff50eae74e2