Zobrazeno 1 - 10
of 222
pro vyhledávání: '"Calvin J Kuo"'
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0226928 (2020)
Secreted R-spondin1-4 proteins (RSPO1-4) orchestrate stem cell renewal and tissue homeostasis by potentiating Wnt/β-catenin signaling. RSPOs induce the turnover of negative Wnt regulators RNF43 and ZNRF3 through a process that requires RSPO interact
Externí odkaz:
https://doaj.org/article/1cf31de1e0034f3a918cc3919c3afbe4
Autor:
Seth C. Cordts, Kanako Yuki, Maria F. Henao Echeverri, Balasubramanian Narasimhan, Calvin J. Kuo, Sindy K. Y. Tang
Publikováno v:
Microsystems & Nanoengineering, Vol 10, Iss 1, Pp 1-14 (2024)
Abstract Patient-derived tumor organoids have emerged as promising models for predicting personalized drug responses in cancer therapy, but they typically lack immune components. Preserving the in vivo association between tumor cells and endogenous i
Externí odkaz:
https://doaj.org/article/4cc23deec4a740e68f26163cdda3668a
Autor:
Franziska Haderk, Yu-Ting Chou, Lauren Cech, Celia Fernández-Méndez, Johnny Yu, Victor Olivas, Ismail M. Meraz, Dora Barbosa Rabago, D. Lucas Kerr, Carlos Gomez, David V. Allegakoen, Juan Guan, Khyati N. Shah, Kari A. Herrington, Oghenekevwe M. Gbenedio, Shigeki Nanjo, Mourad Majidi, Whitney Tamaki, Yashar K. Pourmoghadam, Julia K. Rotow, Caroline E. McCoach, Jonathan W. Riess, J. Silvio Gutkind, Tracy T. Tang, Leonard Post, Bo Huang, Pilar Santisteban, Hani Goodarzi, Sourav Bandyopadhyay, Calvin J. Kuo, Jeroen P. Roose, Wei Wu, Collin M. Blakely, Jack A. Roth, Trever G. Bivona
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Targeted therapy is effective in many tumor types including lung cancer, the leading cause of cancer mortality. Paradigm defining examples are targeted therapies directed against non-small cell lung cancer (NSCLC) subtypes with oncogenic alt
Externí odkaz:
https://doaj.org/article/be0a7eca3725431ab19bfe58739629b9
Autor:
Huiping Li, Takao Miki, Glícia Maria de Almeida, Carina Hanashima, Tomoko Matsuzaki, Calvin J. Kuo, Naoki Watanabe, Makoto Noda
Publikováno v:
iScience, Vol 19, Iss , Pp 559-571 (2019)
Summary: RECK in neural precursor cells (NPCs) was previously found to support Notch-dependent neurogenesis in mice. On the other hand, recent studies implicate RECK in endothelial cells (ECs) in WNT7-triggered canonical WNT signaling essential for b
Externí odkaz:
https://doaj.org/article/6c1a23f119784c9396c9fd836891d8dd
Autor:
Siyuan Ding, Jonathan Diep, Ningguo Feng, Lili Ren, Bin Li, Yaw Shin Ooi, Xin Wang, Kevin F. Brulois, Linda L. Yasukawa, Xingnan Li, Calvin J. Kuo, David A. Solomon, Jan E. Carette, Harry B. Greenberg
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
Cohesin is a multimeric nuclear protein complex which includes STAG2 and is associated with vital roles during cell division. Here in a genome-wide CRISPR-Cas9 screen, the authors identify a novel role of STAG2 as a crucial component of the innate im
Externí odkaz:
https://doaj.org/article/3a027c89acd64fe3a34c3ec69ad04b0a
Autor:
Kasper Karlsson, Moritz J. Przybilla, Eran Kotler, Aziz Khan, Hang Xu, Kremena Karagyozova, Alexandra Sockell, Wing H. Wong, Katherine Liu, Amanda Mah, Yuan-Hung Lo, Bingxin Lu, Kathleen E. Houlahan, Zhicheng Ma, Carlos J. Suarez, Chris P. Barnes, Calvin J. Kuo, Christina Curtis
Publikováno v:
Nature.
The earliest events during human tumour initiation, although poorly characterized, may hold clues to malignancy detection and prevention1. Here we model occult preneoplasia by biallelic inactivation of TP53, a common early event in gastric cancer, in
Autor:
Jessica B. Sarthi, Annie M. Trumbull, Shayda M. Abazari, Vincent van Unen, Joshua E. Chan, Nam Soo Joo, Yanfen Jiang, Calvin J. Kuo, Zachary M. Sellers
Publikováno v:
bioRxiv
Duodenal bicarbonate secretion is critical to epithelial protection, nutrient digestion/absorption and is impaired in cystic fibrosis (CF). We examined if linaclotide, typically used to treat constipation, may also alter duodenal bicarbonate secretio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efb08ed9dff0ad79c18c39630dcec722
https://europepmc.org/articles/PMC10187319/
https://europepmc.org/articles/PMC10187319/
Autor:
Stephanie U. Greer, Lincoln D. Nadauld, Billy T. Lau, Jiamin Chen, Christina Wood-Bouwens, James M. Ford, Calvin J. Kuo, Hanlee P. Ji
Publikováno v:
Genome Medicine, Vol 9, Iss 1, Pp 1-17 (2017)
Abstract Background Genome rearrangements are critical oncogenic driver events in many malignancies. However, the identification and resolution of the structure of cancer genomic rearrangements remain challenging even with whole genome sequencing. Me
Externí odkaz:
https://doaj.org/article/89835a2422ff46e7b32fc7f285b9648c
Autor:
Jonathan E. Wosen, Alexandra Ilstad-Minnihan, Julia Y. Co, Wei Jiang, Dhriti Mukhopadhyay, Nielsen Q. Fernandez-Becker, Calvin J. Kuo, Manuel R. Amieva, Elizabeth D. Mellins
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
The role of intestinal epithelial cells (IECs) in mucosal tolerance and immunity remains poorly understood. We present a method for inducing MHC class II (MHC-II) in human enteroids, “mini-guts” derived from small intestinal crypt stem cells, and
Externí odkaz:
https://doaj.org/article/3663dc00214340a2a9175c550d4c566d
Autor:
Calvin J. Kuo, Gerald R. Crabtree, Haian Fu, Andrea Califano, Christina Curtis, Jonathan S. Weissman, Ilya Shmulevich, Jin Chen, Jose A. Seoane, Hang Xu, Alexandra Sockell, Bahar Tercan, Amanda T. Mah, Teri A. Longacre, Sunny J. Jones, Kasper Karlsson, Walter D. Sobba, Ajay Nair, Andrey Krokhotin, Chiung-Ying Chang, Yuhong Du, Kevin S. Kolahi, Yuan-Hung Lo
Supplementary Figure 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::238040cc0fa6f44debc0bae0c1cfd3d8
https://doi.org/10.1158/2159-8290.22540522
https://doi.org/10.1158/2159-8290.22540522