Zobrazeno 1 - 10
of 345
pro vyhledávání: '"Calvin J Kuo"'
Autor:
Seth C. Cordts, Kanako Yuki, Maria F. Henao Echeverri, Balasubramanian Narasimhan, Calvin J. Kuo, Sindy K. Y. Tang
Publikováno v:
Microsystems & Nanoengineering, Vol 10, Iss 1, Pp 1-14 (2024)
Abstract Patient-derived tumor organoids have emerged as promising models for predicting personalized drug responses in cancer therapy, but they typically lack immune components. Preserving the in vivo association between tumor cells and endogenous i
Externí odkaz:
https://doaj.org/article/4cc23deec4a740e68f26163cdda3668a
Autor:
Franziska Haderk, Yu-Ting Chou, Lauren Cech, Celia Fernández-Méndez, Johnny Yu, Victor Olivas, Ismail M. Meraz, Dora Barbosa Rabago, D. Lucas Kerr, Carlos Gomez, David V. Allegakoen, Juan Guan, Khyati N. Shah, Kari A. Herrington, Oghenekevwe M. Gbenedio, Shigeki Nanjo, Mourad Majidi, Whitney Tamaki, Yashar K. Pourmoghadam, Julia K. Rotow, Caroline E. McCoach, Jonathan W. Riess, J. Silvio Gutkind, Tracy T. Tang, Leonard Post, Bo Huang, Pilar Santisteban, Hani Goodarzi, Sourav Bandyopadhyay, Calvin J. Kuo, Jeroen P. Roose, Wei Wu, Collin M. Blakely, Jack A. Roth, Trever G. Bivona
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Targeted therapy is effective in many tumor types including lung cancer, the leading cause of cancer mortality. Paradigm defining examples are targeted therapies directed against non-small cell lung cancer (NSCLC) subtypes with oncogenic alt
Externí odkaz:
https://doaj.org/article/be0a7eca3725431ab19bfe58739629b9
Autor:
Jie Ding, Sung-Jin Lee, Lukas Vlahos, Kanako Yuki, Cara C. Rada, Vincent van Unen, Meghah Vuppalapaty, Hui Chen, Asmiti Sura, Aaron K. McCormick, Madeline Tomaske, Samira Alwahabi, Huy Nguyen, William Nowatzke, Lily Kim, Lisa Kelly, Douglas Vollrath, Andrea Califano, Wen-Chen Yeh, Yang Li, Calvin J. Kuo
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Derangements of the blood-brain barrier (BBB) or blood-retinal barrier (BRB) occur in disorders ranging from stroke, cancer, diabetic retinopathy, and Alzheimer’s disease. The Norrin/FZD4/TSPAN12 pathway activates WNT/β-catenin signaling,
Externí odkaz:
https://doaj.org/article/31df630cc0d74d1eb51da2d91c5e7f3c
Autor:
Ameen A. Salahudeen, Jose A. Seoane, Kanako Yuki, Amanda T. Mah, Amber R. Smith, Kevin Kolahi, Sean M. De la O, Daniel J. Hart, Jie Ding, Zhicheng Ma, Sammy A. Barkal, Navika D. Shukla, Chuck H. Zhang, Michael A. Cantrell, Arpit Batish, Tatsuya Usui, David E. Root, William C. Hahn, Christina Curtis, Calvin J. Kuo
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113355- (2023)
Summary: Somatic copy number gains are pervasive across cancer types, yet their roles in oncogenesis are insufficiently evaluated. This inadequacy is partly due to copy gains spanning large chromosomal regions, obscuring causal loci. Here, we employe
Externí odkaz:
https://doaj.org/article/266edeeec93f49ce89efe1c759020698
Autor:
Min Yu, Yage Nie, Jiawen Yang, Shilun Yang, Rui Li, Varsha Rao, Xiaoyan Hu, Cheng Fang, Simeng Li, Dengpan Song, Fuyou Guo, Michael P. Snyder, Howard Y. Chang, Calvin J. Kuo, Jin Xu, Junlei Chang
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113392- (2023)
Summary: The blood-brain barrier (BBB) is primarily manifested by a variety of physiological properties of brain endothelial cells (ECs), but the molecular foundation for these properties remains incompletely clear. Here, we generate a comprehensive
Externí odkaz:
https://doaj.org/article/b5dca1762ab541118d63d893ef4ecbbc
Autor:
Bin Zhang, Le Xuan Truong Nguyen, Dandan Zhao, David E. Frankhouser, Huafeng Wang, Dinh Hoa Hoang, Junjing Qiao, Christina Abundis, Matthew Brehove, Yu-Lin Su, Yuxin Feng, Anthony Stein, Lucy Ghoda, Adrianne Dorrance, Danilo Perrotti, Zhen Chen, Anjia Han, Flavia Pichiorri, Jie Jin, Tijana Jovanovic-Talisman, Michael A. Caligiuri, Calvin J. Kuo, Akihiko Yoshimura, Ling Li, Russell C. Rockne, Marcin Kortylewski, Yi Zheng, Nadia Carlesso, Ya-Huei Kuo, Guido Marcucci
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-19 (2021)
Abstract Background During acute myeloid leukemia (AML) growth, the bone marrow (BM) niche acquires significant vascular changes that can be offset by therapeutic blast cytoreduction. The molecular mechanisms of this vascular plasticity remain to be
Externí odkaz:
https://doaj.org/article/52f9905cc5f14aa08a70fe465bcdd2b1
Autor:
Daniel R. Hunt, Katarina C. Klett, Shamik Mascharak, Huiyuan Wang, Diana Gong, Junzhe Lou, Xingnan Li, Pamela C. Cai, Riley A. Suhar, Julia Y. Co, Bauer L. LeSavage, Abbygail A. Foster, Yuan Guan, Manuel R. Amieva, Gary Peltz, Yan Xia, Calvin J. Kuo, Sarah C. Heilshorn
Publikováno v:
Advanced Science, Vol 8, Iss 10, Pp n/a-n/a (2021)
Abstract Human intestinal organoids from primary human tissues have the potential to revolutionize personalized medicine and preclinical gastrointestinal disease models. A tunable, fully defined, designer matrix, termed hyaluronan elastin‐like prot
Externí odkaz:
https://doaj.org/article/51791a5732c64f4090690b8d74723f7c
Autor:
Huiping Li, Takao Miki, Glícia Maria de Almeida, Carina Hanashima, Tomoko Matsuzaki, Calvin J. Kuo, Naoki Watanabe, Makoto Noda
Publikováno v:
iScience, Vol 19, Iss , Pp 559-571 (2019)
Summary: RECK in neural precursor cells (NPCs) was previously found to support Notch-dependent neurogenesis in mice. On the other hand, recent studies implicate RECK in endothelial cells (ECs) in WNT7-triggered canonical WNT signaling essential for b
Externí odkaz:
https://doaj.org/article/6c1a23f119784c9396c9fd836891d8dd
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0226928 (2020)
Secreted R-spondin1-4 proteins (RSPO1-4) orchestrate stem cell renewal and tissue homeostasis by potentiating Wnt/β-catenin signaling. RSPOs induce the turnover of negative Wnt regulators RNF43 and ZNRF3 through a process that requires RSPO interact
Externí odkaz:
https://doaj.org/article/1cf31de1e0034f3a918cc3919c3afbe4
Autor:
Siyuan Ding, Jonathan Diep, Ningguo Feng, Lili Ren, Bin Li, Yaw Shin Ooi, Xin Wang, Kevin F. Brulois, Linda L. Yasukawa, Xingnan Li, Calvin J. Kuo, David A. Solomon, Jan E. Carette, Harry B. Greenberg
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
Cohesin is a multimeric nuclear protein complex which includes STAG2 and is associated with vital roles during cell division. Here in a genome-wide CRISPR-Cas9 screen, the authors identify a novel role of STAG2 as a crucial component of the innate im
Externí odkaz:
https://doaj.org/article/3a027c89acd64fe3a34c3ec69ad04b0a