Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Calvin D Roskelley"'
Autor:
Blake Gilks, Martin Köbel, Diana Canals Hernaez, Michael R Hughes, Pamela Dean, Peter Bergqvist, Ismael Samudio, Ola Blixt, Katharina Wiedemeyer, Yicong Li, Chris Bond, Eric Cruz, Calvin D Roskelley, Kelly M McNagny
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background The success of new targeted cancer therapies has been dependent on the identification of tumor-specific antigens. Podocalyxin (Podxl) is upregulated on tumors with high metastatic index and its presence is associated with poor outcome, thu
Externí odkaz:
https://doaj.org/article/05e2507cade04908818751ee8569e299
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0165162 (2016)
"Rods and rings" (RR) and loukoumasomes are similarly shaped, subcellular macromolecular structures with as yet unknown function. RR, so named because of their shape, are formed in response to inhibition in the GTP or CTP synthetic pathways and are h
Externí odkaz:
https://doaj.org/article/9adede3c1c814fd2b45bf88567b6bccf
Autor:
Steven Maltby, Spencer Freeman, Matthew J Gold, Jennifer H E Baker, Andrew I Minchinton, Michael R Gold, Calvin D Roskelley, Kelly M McNagny
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18160 (2011)
Tumor growth and metastasis are determined by the complex interplay of factors, including those intrinsic to tumor cells and extrinsic factors associated with the tumor microenvironment. Our previous work demonstrated key roles for CD34 in the mainte
Externí odkaz:
https://doaj.org/article/a9e584cb1ed74e73b8c48f209839fbea
Autor:
Pamela Austin, Markus Heller, David E Williams, Lawrence P McIntosh, A Wayne Vogl, Leonard J Foster, Raymond J Andersen, Michel Roberge, Calvin D Roskelley
Publikováno v:
PLoS ONE, Vol 5, Iss 5, p e10836 (2010)
Neopetrosiamide A (NeoA) is a 28-amino acid tricyclic peptide originally isolated from a marine sponge as a tumor cell invasion inhibitor whose mechanism of action is unknown.We show that NeoA reversibly inhibits tumor cell adhesion, disassembles foc
Externí odkaz:
https://doaj.org/article/57f017d6977d44cdb2c8b57cfb8cc216
Autor:
Julie S Nielsen, Marcia L Graves, Shierley Chelliah, A Wayne Vogl, Calvin D Roskelley, Kelly M McNagny
Publikováno v:
PLoS ONE, Vol 2, Iss 2, p e237 (2007)
BackgroundPodocalyxin is a CD34-related transmembrane protein involved in hematopoietic cell homing, kidney morphogenesis, breast cancer progression, and epithelial cell polarization. Although this sialomucin has been shown to block cell adhesion, th
Externí odkaz:
https://doaj.org/article/8d897ac60abc49fa8e8907992a36b848
Autor:
Julyanne Brassard, Michael R. Hughes, Pamela Dean, Diana Canals Hernaez, Shelby Thornton, Allyson C. Banville, Julian Smazynski, Mary Warren, Kevin Zhang, Katy Milne, C. Blake Gilks, Anne-Marie Mes-Masson, David G. Huntsman, Brad H. Nelson, Calvin D. Roskelley, Kelly M. McNagny
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionTargeted-immunotherapies such as antibody-drug conjugates (ADC), chimeric antigen receptor (CAR) T cells or bispecific T-cell engagers (eg, BiTE®) all aim to improve cancer treatment by directly targeting cancer cells while sparing healt
Externí odkaz:
https://doaj.org/article/63a8aa00a3774a79b38d00326168392f
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 27, Iss 11, p 301 (2022)
Finding the ideal epitope to target is a key element for the development of an antibody-drug conjugate (ADC). To maximize drug delivery to tumor cells and reduce side effects, this epitope should be specific to cancer cells and spare all normal tissu
Externí odkaz:
https://doaj.org/article/71d9ca3fa2974276880422fd0d88c864
Publikováno v:
Biochemical Journal. 479:2351-2364
Apoptosis is a critical process for the maintenance of cell populations, and involves mitochondrial depolarization, the sequential cleavage of caspase-9 and -3, followed by the externalization of phosphatidylserine (PS) on the plasma membrane. The ac
Autor:
Calvin D. Roskelley, Pauline Johnson, Michael R. Gold, T. Michael Underhill, Kelly M. McNagny, Kimberly C. Wiegand, Marie-Renee Blanchet, Jacqueline C.Y. Lai, Pamela Dean, Jawairia Atif, Spencer A. Freeman, Yu-Hsuan Huang, Arif A. Arif
S1. Collagen staining of the inflamed lungs. S2. Extravasation of tumor cells from microvasculature. S3. Effects of methotrexate on the viability of B16F0. S4. MoDM conditioned media enhances the survival of B16F0 cells maintained in suspension cultu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4986d630810dc6fd0706ad16c517b663
https://doi.org/10.1158/1541-7786.22526246.v1
https://doi.org/10.1158/1541-7786.22526246.v1
Autor:
Calvin D. Roskelley, Christopher R. Mueller, Jane Cipollone, Gwen MacDonald, Marcia Graves, Lixin Zhou
PDF file - 525K, A dominant-negative AP1 effector decreases BRCA1 promoter activity in monolayer culture.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::513845cdfd1b50672e8664119982e99f
https://doi.org/10.1158/1541-7786.22517907.v1
https://doi.org/10.1158/1541-7786.22517907.v1