Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Calvin B Williams"'
Autor:
Sara E. Sabbagh, Dipica Haribhai, Jill A. Gershan, James Verbsky, James Nocton, Maryam Yassai, Elena N. Naumova, Erin Hammelev, Mahua Dasgupta, Ke Yan, Jack Gorski, Calvin B. Williams
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/1052c5151fa54bb9b97a939ee8a7ee29
Autor:
Sara E. Sabbagh, Dipica Haribhai, Jill A. Gershan, James Verbsky, James Nocton, Maryam Yassai, Elena N. Naumova, Erin Hammelev, Mahua Dasgupta, Ke Yan, Jack Gorski, Calvin B. Williams
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Recurrent exposures to a pathogenic antigen remodel the CD8+ T cell compartment and generate a functional memory repertoire that is polyclonal and complex. At the clonotype level, the response to the conserved influenza antigen, M158–66 has been we
Externí odkaz:
https://doaj.org/article/d54c6d29ecf14b399c9ea36992d8a7cf
Autor:
Erica G Schmitt, Calvin B Williams
Publikováno v:
Frontiers in Immunology, Vol 4 (2013)
CD4+ CD25+ Foxp3+ regulatory T (Treg) cells are essential to the balance between pro- and anti-inflammatory responses. There are two major subsets of Treg cells, natural Treg (nTreg) cells that develop in the thymus, and induced Treg (iTreg) cells th
Externí odkaz:
https://doaj.org/article/c8dc0158de0847dc97ebc4c802b0a969
Autor:
Achia Khatun, Xiaopeng Wu, Fu Qi, Kexin Gai, Arjun Kharel, Matthew R. Kudek, Lisa Fraser, Ashley Ceicko, Moujtaba Y. Kasmani, Amber Majnik, Robert Burns, Yi‐Guang Chen, Nita Salzman, Elizabeth J. Taparowsky, Dayu Fang, Calvin B. Williams, Weiguo Cui
Publikováno v:
Advanced Science, Vol 10, Iss 28, Pp n/a-n/a (2023)
Abstract Regulatory T (Treg) cells are inevitable to prevent deleterious immune responses to self and commensal microorganisms. Treg function requires continuous expression of the transcription factor (TF) FOXP3 and is divided into two major subsets:
Externí odkaz:
https://doaj.org/article/786eb5c93e3443a6b323cd0698684eb8
Autor:
Yuanhua Cai, Jocelyn A. Schroeder, Weiqing Jing, Cody Gurski, Calvin B. Williams, Shaoyuan Wang, Bonnie N. Dittel, Qizhen Shi
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system with no cure yet. Here, we report genetic engineering of hematopoietic stem cells (HSCs) to express myelin oligodendrocyte glycoprotein (MOG), specific
Externí odkaz:
https://doaj.org/article/ec6a2fddd5f34326a50e945eeb517ef7
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 23, Iss , Pp 719-730 (2021)
While platelet-specific gene therapy is effective in inducing immune tolerance to a targeted protein, how the reactivity of pre-existing immunity affects the efficacy, and whether CD8 T cells were involved in tolerization, is unclear. In this study,
Externí odkaz:
https://doaj.org/article/6b892202126248749c94d0de8a61d1a6
Autor:
Dipica Haribhai, Xiaofeng Luo, Juan Chen, Shuang Jia, Linzheng Shi, Jocelyn A. Schroeder, Hartmut Weiler, Richard H. Aster, Martin J. Hessner, Jianda Hu, Calvin B. Williams, Qizhen Shi
Publikováno v:
Blood Advances, Vol 1, Iss 2, Pp 139-151 (2016)
Abstract: Platelets are a rich source of many cytokines and chemokines including transforming growth factor β 1 (TGF-β1). TGF-β1 is required to convert conventional CD4+ T (Tconv) cells into induced regulatory T (iTreg) cells that express the tran
Externí odkaz:
https://doaj.org/article/1c83410e71e3486a8582cf196bbae65d
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 23, Iss, Pp 719-730 (2021)
Molecular Therapy. Nucleic Acids
Molecular Therapy. Nucleic Acids
While platelet-specific gene therapy is effective in inducing immune tolerance to a targeted protein, how the reactivity of pre-existing immunity affects the efficacy, and whether CD8 T cells were involved in tolerization, is unclear. In this study,
Autor:
Yongwei Zheng, Dipica Haribhai, Richard H. Aster, Renren Wen, Calvin B. Williams, Wen Zhu, Demin Wang
Publikováno v:
J Immunol
Heparin-induced thrombocytopenia (HIT) is an immune-mediated disorder that can cause fatal arterial or venous thrombosis/thromboembolism. Immune complexes consisting of heparin, platelet factor 4 (PF4) and PF4/heparin-reactive antibodies are central
Autor:
Rebecca S. LaRue, Louisa E. Sjaastad, Mark S. Anderson, Calvin B. Williams, Praful Aggarwal, Maria-Luisa Alegre, Ulrich Broeckel, Shawn A. Mahmud, Irina Proekt, Dimitre R. Simeonov, Jason B. Williams, Michael A. Farrar, Weishan Huang, Jonathan C. Jeschke, Corey N. Miller, Roland Ruscher, David L. Owen, Christine Henzler, Justin A. Spanier, Can Hekim, Avery August, Alexander Marson, Ye Zheng
Publikováno v:
Nature immunology
The developmental programs that generate a broad repertoire of regulatory T cells (Treg cells) able to respond to both self antigens and non-self antigens remain unclear. Here we found that mature Treg cells were generated through two distinct develo