Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Calvin B Williams"'
Autor:
Sara E. Sabbagh, Dipica Haribhai, Jill A. Gershan, James Verbsky, James Nocton, Maryam Yassai, Elena N. Naumova, Erin Hammelev, Mahua Dasgupta, Ke Yan, Jack Gorski, Calvin B. Williams
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/1052c5151fa54bb9b97a939ee8a7ee29
Autor:
Sara E. Sabbagh, Dipica Haribhai, Jill A. Gershan, James Verbsky, James Nocton, Maryam Yassai, Elena N. Naumova, Erin Hammelev, Mahua Dasgupta, Ke Yan, Jack Gorski, Calvin B. Williams
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Recurrent exposures to a pathogenic antigen remodel the CD8+ T cell compartment and generate a functional memory repertoire that is polyclonal and complex. At the clonotype level, the response to the conserved influenza antigen, M158–66 has been we
Externí odkaz:
https://doaj.org/article/d54c6d29ecf14b399c9ea36992d8a7cf
Autor:
Achia Khatun, Xiaopeng Wu, Fu Qi, Kexin Gai, Arjun Kharel, Matthew R. Kudek, Lisa Fraser, Ashley Ceicko, Moujtaba Y. Kasmani, Amber Majnik, Robert Burns, Yi‐Guang Chen, Nita Salzman, Elizabeth J. Taparowsky, Dayu Fang, Calvin B. Williams, Weiguo Cui
Publikováno v:
Advanced Science, Vol 10, Iss 28, Pp n/a-n/a (2023)
Abstract Regulatory T (Treg) cells are inevitable to prevent deleterious immune responses to self and commensal microorganisms. Treg function requires continuous expression of the transcription factor (TF) FOXP3 and is divided into two major subsets:
Externí odkaz:
https://doaj.org/article/786eb5c93e3443a6b323cd0698684eb8
Autor:
Yuanhua Cai, Jocelyn A. Schroeder, Weiqing Jing, Cody Gurski, Calvin B. Williams, Shaoyuan Wang, Bonnie N. Dittel, Qizhen Shi
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system with no cure yet. Here, we report genetic engineering of hematopoietic stem cells (HSCs) to express myelin oligodendrocyte glycoprotein (MOG), specific
Externí odkaz:
https://doaj.org/article/ec6a2fddd5f34326a50e945eeb517ef7
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 23, Iss , Pp 719-730 (2021)
While platelet-specific gene therapy is effective in inducing immune tolerance to a targeted protein, how the reactivity of pre-existing immunity affects the efficacy, and whether CD8 T cells were involved in tolerization, is unclear. In this study,
Externí odkaz:
https://doaj.org/article/6b892202126248749c94d0de8a61d1a6
Autor:
Dipica Haribhai, Xiaofeng Luo, Juan Chen, Shuang Jia, Linzheng Shi, Jocelyn A. Schroeder, Hartmut Weiler, Richard H. Aster, Martin J. Hessner, Jianda Hu, Calvin B. Williams, Qizhen Shi
Publikováno v:
Blood Advances, Vol 1, Iss 2, Pp 139-151 (2016)
Abstract: Platelets are a rich source of many cytokines and chemokines including transforming growth factor β 1 (TGF-β1). TGF-β1 is required to convert conventional CD4+ T (Tconv) cells into induced regulatory T (iTreg) cells that express the tran
Externí odkaz:
https://doaj.org/article/1c83410e71e3486a8582cf196bbae65d
Autor:
Elena N. Naumova, Maryam B. Yassai, Wendy Demos, Erica Reed, Melissa Unruh, Dipica Haribhai, Calvin B. Williams, Yuri N. Naumov, Jack Gorski
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
T-cell memory to pathogens can be envisioned as a receptor-based imprint of the pathogenic environment on the naïve repertoire of clonotypes. Recurrent exposures to a pathogen inform and reinforce memory, leading to a mature state. The complexity an
Externí odkaz:
https://doaj.org/article/a8af07e64edb48ed90dc940711435c30
Autor:
Xiaofeng Luo, Juan Chen, Jocelyn A. Schroeder, Kenneth P. Allen, Christina K. Baumgartner, Subramaniam Malarkannan, Jianda Hu, Calvin B. Williams, Qizhen Shi
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Delivery of gene therapy as well as of biologic therapeutics is often hampered by the immune response of the subject receiving the therapy. We have reported that effective gene therapy for hemophilia utilizing platelets as a delivery vehicle engender
Externí odkaz:
https://doaj.org/article/516cae0516f04709af960b52562436a1
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 23, Iss, Pp 719-730 (2021)
Molecular Therapy. Nucleic Acids
Molecular Therapy. Nucleic Acids
While platelet-specific gene therapy is effective in inducing immune tolerance to a targeted protein, how the reactivity of pre-existing immunity affects the efficacy, and whether CD8 T cells were involved in tolerization, is unclear. In this study,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e87d9fcce18d19a187ae9054765b80a1
http://www.sciencedirect.com/science/article/pii/S2162253120304078
http://www.sciencedirect.com/science/article/pii/S2162253120304078
Autor:
Yongwei Zheng, Dipica Haribhai, Richard H. Aster, Renren Wen, Calvin B. Williams, Wen Zhu, Demin Wang
Publikováno v:
J Immunol
Heparin-induced thrombocytopenia (HIT) is an immune-mediated disorder that can cause fatal arterial or venous thrombosis/thromboembolism. Immune complexes consisting of heparin, platelet factor 4 (PF4) and PF4/heparin-reactive antibodies are central
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f5c66aa57cddc69d98fd138de240ddb
https://doi.org/10.4049/jimmunol.1900196
https://doi.org/10.4049/jimmunol.1900196