Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Calvin, Tiengwe"'
Autor:
Samuel M Duncan, Carla Gilabert Carbajo, Rupa Nagar, Qi Zhong, Conor Breen, Michael A J Ferguson, Calvin Tiengwe
Publikováno v:
PLoS Pathogens, Vol 20, Iss 6, p e1012333 (2024)
The bloodstream form of Trypanosoma brucei expresses large poly-N-acetyllactosamine (pNAL) chains on complex N-glycans of a subset of glycoproteins. It has been hypothesised that pNAL may be required for receptor-mediated endocytosis. African trypano
Externí odkaz:
https://doaj.org/article/3325ae2be9464f24bc2000338282b7f5
Autor:
Carla Gilabert Carbajo, Lucy J Cornell, Youssef Madbouly, Zhihao Lai, Phillip A Yates, Michele Tinti, Calvin Tiengwe
Publikováno v:
PLoS Pathogens, Vol 17, Iss 6, p e1009696 (2021)
Iron is an essential regulatory signal for virulence factors in many pathogens. Mammals and bloodstream form (BSF) Trypanosoma brucei obtain iron by receptor-mediated endocytosis of transferrin bound to receptors (TfR) but the mechanisms by which T.
Externí odkaz:
https://doaj.org/article/77a1b755c58441838b870af7cd58b3a6
Autor:
Calvin Tiengwe
Publikováno v:
mSphere, Vol 4, Iss 5 (2019)
ABSTRACT Calvin Tiengwe works on posttranscriptional gene regulation and iron homeostasis in the parasitic protozoan Trypanosoma brucei. In this mSphere of Influence article, he reflects on how the paper “Comprehensive identification of RNA-protein
Externí odkaz:
https://doaj.org/article/41c4991d564f46c080f5efa01de5723e
Publikováno v:
EuPA Open Proteomics, Vol 7, Iss C, Pp 11-19 (2015)
We review and demonstrate how an empirical Bayes method, shrinking a protein's sample variance towards a pooled estimate, leads to far more powerful and stable inference to detect significant changes in protein abundance compared to ordinary t-tests.
Externí odkaz:
https://doaj.org/article/29039cbd896f404ca56c59dd0a86aee2
Publikováno v:
PLoS Pathogens, Vol 13, Iss 5, p e1006366 (2017)
Bloodstream-form African trypanosomes encode two structurally related glycosylphosphatidylinositol (GPI)-anchored proteins that are critical virulence factors, variant surface glycoprotein (VSG) for antigenic variation and transferrin receptor (TfR)
Externí odkaz:
https://doaj.org/article/fda216269f884d99a84672e511898b67
Autor:
Ceire J, Wincott, Gayathri, Sritharan, Henry J, Benns, Dana, May, Carla, Gilabert-Carbajo, Monique, Bunyan, Aisling R, Fairweather, Eduardo, Alves, Ivan, Andrew, Laurence, Game, Eva-Maria, Frickel, Calvin, Tiengwe, Sarah E, Ewald, Matthew A, Child
Publikováno v:
Cell reports methods. 2(8)
Cellular barcoding techniques are powerful tools to understand microbial pathogenesis. However, barcoding strategies have not been broadly applied to protozoan parasites, which have unique genomic structures and virulence strategies compared with vir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d4646c83f1dcc96fe089560f794b1241
https://pubmed.ncbi.nlm.nih.gov/36046624
https://pubmed.ncbi.nlm.nih.gov/36046624
Publikováno v:
Journal of Biological Chemistry. 295:2227-2238
The transferrin receptor (TfR) of the bloodstream form (BSF) of Trypanosoma brucei is a heterodimer comprising glycosylphosphatidylinositol (GPI)-anchored expression site–associated gene 6 (ESAG6 or E6) and soluble ESAG7. Mature E6 has five N-glyca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e15e4d5c48d211bc28627686361c27f6
https://doi.org/10.1074/jbc.ra119.010847
https://doi.org/10.1074/jbc.ra119.010847
Autor:
Ceire J. Wincott, Gayathri Sritharan, Henry J. Benns, Farzana B. Liakath, Carla Gilabert-Carbajo, Monique Bunyan, Aisling R. Fairweather, Eduardo Alves, Ivan Andrew, Laurence Game, Eva M. Frickel, Calvin Tiengwe, Sarah E. Ewald, Matthew A. Child
Molecular barcoding techniques have emerged as powerful tools to understand microbial pathogenesis. However, barcoding strategies have not been extended to protozoan parasites, which have unique genomic structures and virulence strategies compared to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e48515ef71998e8a50da733382ffbfc
Autor:
Calvin Tiengwe, Lucio Marcello, Helen Farr, Nicholas Dickens, Steven Kelly, Michal Swiderski, Diane Vaughan, Keith Gull, J. David Barry, Stephen D. Bell, Richard McCulloch
Publikováno v:
Cell Reports, Vol 2, Iss 1, Pp 185-197 (2012)
Identification of replication initiation sites, termed origins, is a crucial step in understanding genome transmission in any organism. Transcription of the Trypanosoma brucei genome is highly unusual, with each chromosome comprising a few discrete t
Externí odkaz:
https://doaj.org/article/9f73ccb55f114bfdbd6e6e615f13a980
Autor:
Lucy J. Cornell, Youssef Madbouly, Michele Tinti, Zhihao Lai, Calvin Tiengwe, Phillip A. Yates, Carla Gilabert Carbajo
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 6, p e1009696 (2021)
PLoS Pathogens, Vol 17, Iss 6, p e1009696 (2021)
Iron is an essential regulatory signal for virulence factors in many pathogens. Mammals and bloodstream form (BSF) Trypanosoma brucei obtain iron by receptor-mediated endocytosis of transferrin bound to receptors (TfR) but the mechanisms by which T.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba78dcdaba4b5993fff6eee54bf10af3
https://pubmed.ncbi.nlm.nih.gov/34161395
https://pubmed.ncbi.nlm.nih.gov/34161395