Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation

Autor: Ananda S. Mirchandani, Stephen J. Jenkins, Calum C. Bain, Manuel A. Sanchez-Garcia, Hannah Lawson, Patricia Coelho, Fiona Murphy, David M. Griffith, Ailiang Zhang, Tyler Morrison, Tony Ly, Simone Arienti, Pranvera Sadiku, Emily R. Watts, Rebecca. S. Dickinson, Leila Reyes, George Cooper, Sarah Clark, David Lewis, Van Kelly, Christos Spanos, Kathryn M. Musgrave, Liam Delaney, Isla Harper, Jonathan Scott, Nicholas J. Parkinson, Anthony J. Rostron, J. Kenneth Baillie, Sara Clohisey, Clare Pridans, Lara Campana, Philip Starkey Lewis, A. John Simpson, David H. Dockrell, Jürgen Schwarze, Nikhil Hirani, Peter J. Ratcliffe, Christopher W. Pugh, Kamil Kranc, Stuart J. Forbes, Moira K. B. Whyte, Sarah R. Walmsley

Publikováno v: Mirchandani, A S, Jenkins, S J, Bain, C C, Sanchez Garcia, M A, Lawson, H, Coelho, P, Murphy, F, Griffith, D, Zhang, A, Morrison, T, Ly, T, Arienti, S, Sadiku, P, Watts, E R, Dickinson, R, Reyes, L, Cooper, G, Clark, S, Lewis, D, Kelly, V, Spanos, C, Musgrave, K M, Delaney, L, Harper, I, Scott, J, Parkinson, N, Rostron, A J, Baillie, J K, Clohisey, S, Pridans, C, Campana, L, Starkey Lewis, P, Simpson, A J, Dockrell, D H, Schwarze, J, Hirani, N, Ratcliffe, P J, Pugh, C W, Kranc, K, Forbes, S J, Whyte, M K B & Walmsley, S R 2022, ' Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation ', Nature Immunology . https://doi.org/0.1038/s41590-022-01216-z

Hypoxemia is a defining feature of acute respiratory distress syndrome (ARDS), an often-fatal complication of pulmonary or systemic inflammation, yet the resulting tissue hypoxia, and its impact on immune responses, is often neglected. In the present

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09ab39b51379ba91e60afdc26dc1fbd1
https://doi.org/10.1038/s41590-022-01216-z

The role of monocyte-derived macrophages in the lung: It’s all about context

Autor: Wouter T’Jonck, Calum C. Bain

Publikováno v: T’jonck, W & Bain, C C 2023, ' The role of monocyte-derived macrophages in the lung: It’s all about context ', International Journal of Biochemistry and Cell Biology, vol. 159, pp. 106421 . https://doi.org/10.1016/j.biocel.2023.106421

Macrophages are present in every tissue of the body where they play crucial roles in maintaining tissue homeostasis and providing front line defence against pathogens. Arguably, this is most important at mucosal barrier tissues, such as the lung and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f672468b52e8fe13eade58aaf146df00
https://hdl.handle.net/20.500.11820/d8215950-9f89-4629-99fb-3ad47eb1dd8e

Origin, Differentiation, and Function of Intestinal Macrophages

Autor: Calum C. Bain, Anika Schridde

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Macrophages are increasingly recognized as essential players in the maintenance of intestinal homeostasis and as key sentinels of the intestinal immune system. However, somewhat paradoxically, they are also implicated in chronic pathologies of the ga

Externí odkaz: https://doaj.org/article/6a9c5951f4bb4cde85e4827d072df623

CD11c identifies microbiota and EGR2-dependent MHCII+ serous cavity macrophages with sexually dimorphic fate in mice

Autor: Calum C. Bain, Pieter A. Louwe, Nicholas J. Steers, Alberto Bravo‐Blas, Lizi M. Hegarty, Clare Pridans, Simon W.F. Milling, Andrew S. MacDonald, Dominik Rückerl, Stephen J. Jenkins

Publikováno v: Bain, C C, Louwe, P A, Steers, N, Bravo-Blas, A, Hegarty, L, Pridans, C, Milling, S, MacDonald, A S, Ruckerl, D & Jenkins, S J 2022, ' CD11c identifies microbiota and EGR2-dependent MHCII+ serous cavity macrophages with sexually dimorphic fate in mice ', European Journal of Immunology, vol. 52, no. 8, pp. 1243-1257 . https://doi.org/10.1002/eji.202149756
Bain, C C, Louwe, P A, Steers, N J, Bravo-Blas, A, Hegarty, L M, Pridans, C, Milling, S W F, MacDonald, A S, Rückerl, D & Jenkins, S J 2022, ' CD11c identifies microbiota and EGR2-dependent MHCII+ serous cavity macrophages with sexually dimorphic fate in mice ', European journal of immunology . https://doi.org/10.1002/eji.202149756

The murine serous cavities contain a rare and enigmatic population of short-lived F4/80 loMHCII + macrophages but what regulates their development, survival, and fate is unclear. Here, we show that mature F4/80 loMHCII + peritoneal macrophages arise

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2ff8dc24f598395d90d3549f866efb6
https://www.pure.ed.ac.uk/ws/files/290984053/Eur_J_Immunol_2022_Bain_CD11c_identifies_microbiota_and_EGR2_u2010dependent_MHCII_serous_cavity_macrophages_with_sexually.pdf

CSF1R-dependent macrophages in the salivary gland are essential for epithelial regeneration following radiation-induced injury

Autor: John G. McKendrick, Gareth-Rhys Jones, Sonia S. Elder, Ella Mercer, Marlene S. Magalhaes, Cecilia Rocchi, Lizi M. Hegarty, Amanda L. Johnson, Christoph Schneider, Burkhard Becher, Clare Pridans, Neil Mabbott, Zhaoyuan Liu, Florent Ginhoux, Marc Bajenoff, Rebecca Gentek, Calum C. Bain, Elaine Emmerson

The salivary glands often become damaged in individuals receiving radiotherapy for head and neck cancer, resulting in xerostomia, or chronic dry mouth. This leads to detrimental effects on their health and quality of life, for which there is no regen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::69f4535b51b09e73c3110ed64f3d6510
https://doi.org/10.1101/2022.06.12.495803