Zobrazeno 1 - 10
of 384
pro vyhledávání: '"Calum A, MacRae"'
Autor:
James Truslow, Angela Spillane, Huiming Lin, Katherine Cyr, Adeeti Ullal, Edith Arnold, Ron Huang, Laura Rhodes, Jennifer Block, Jamie Stark, James Kretlow, Alexis L. Beatty, Andreas Werdich, Deepali Bankar, Matt Bianchi, Ian Shapiro, Jaime Villalpando, Sharon Ravindran, Irida Mance, Adam Phillips, John Earl, Rahul C. Deo, Sumbul A. Desai, Calum A. MacRae
Publikováno v:
npj Digital Medicine, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract Physical activity or structured exercise is beneficial in a wide range of circumstances. Nevertheless, individual-level data on differential responses to various types of activity are not yet sufficient in scale, duration or level of annotat
Externí odkaz:
https://doaj.org/article/c192414062ae4c2c91f292e042f17665
Publikováno v:
SAGE Open Medicine, Vol 12 (2024)
Background: Optimal guideline-directed medical therapy is rarely attained in practice, resulting in inadequate control of diseases such as hypertension, with poorer results in under-resourced communities. Technology, including artificial intelligence
Externí odkaz:
https://doaj.org/article/1aa2eb96fc3548c9adc5b7b31dadaa51
Autor:
Ryuichiro Yagi, Shinichi Goto, Yukihiro Himeno, Yoshinori Katsumata, Masahiro Hashimoto, Calum A. MacRae, Rahul C. Deo
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Anthracyclines can cause cancer therapy-related cardiac dysfunction (CTRCD) that adversely affects prognosis. Despite guideline recommendations, only half of the patients undergo surveillance echocardiograms. An AI model detecting reduced le
Externí odkaz:
https://doaj.org/article/3dd4166c5df2494caeb4df921f5a2f48
Autor:
Jack C. Saywell, Max S. Carey, Philip S. Light, Stuart S. Szigeti, Alistair R. Milne, Karandeep S. Gill, Matthew L. Goh, Viktor S. Perunicic, Nathanial M. Wilson, Calum D. Macrae, Alexander Rischka, Patrick J. Everitt, Nicholas P. Robins, Russell P. Anderson, Michael R. Hush, Michael J. Biercuk
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Atom-interferometric quantum sensors could revolutionize navigation, civil engineering, and Earth observation. However, operation in real-world environments is challenging due to external interference, platform noise, and constraints on size
Externí odkaz:
https://doaj.org/article/868789d75f4e49668aef34394be679f0
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
A definitive, authoritative approach to evaluate the causes of unexpected, and ultimately unexplained, pediatric deaths remains elusive, relegating final conclusions to diagnoses of exclusion in the vast majority of cases. Research into unexplained p
Externí odkaz:
https://doaj.org/article/0446325b34b54530b215e28c7ee54730
Autor:
Kendall E Martin, Padmapriyadarshini Ravisankar, Manu Beerens, Calum A MacRae, Joshua S Waxman
Publikováno v:
eLife, Vol 12 (2023)
Maintenance of cardiomyocyte identity is vital for normal heart development and function. However, our understanding of cardiomyocyte plasticity remains incomplete. Here, we show that sustained expression of the zebrafish transcription factor Nr2f1a
Externí odkaz:
https://doaj.org/article/f836804f17944076be9c284e9dd8ddfc
Autor:
Jason R. Nielson, Anjali K. Nath, Kim P. Doane, Xu Shi, Jangwoen Lee, Emily G. Tippetts, Kusumika Saha, Jordan Morningstar, Kevin G. Hicks, Adriano Chan, Yanbin Zhao, Amy Kelly, Tara B. Hendry-Hofer, Alyssa Witeof, Patrick Y. Sips, Sari Mahon, Vikhyat S. Bebarta, Vincent Jo Davisson, Gerry R. Boss, Jared Rutter, Calum A. MacRae, Matthew Brenner, Robert E. Gerszten, Randall T. Peterson
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Although cyanide’s biological effects are pleiotropic, its most obvious effects are as a metabolic poison. Cyanide potently inhibits cytochrome c oxidase and potentially other metabolic enzymes, thereby unleashing a cascade of metabolic pe
Externí odkaz:
https://doaj.org/article/cb54f482aaef485c9442a4f1d31f3076
Autor:
Keith C. Cheng, Rebecca D. Burdine, Mary E. Dickinson, Stephen C. Ekker, Alex Y. Lin, K. C. Kent Lloyd, Cathleen M. Lutz, Calum A. MacRae, John H. Morrison, David H. O'Connor, John H. Postlethwait, Crystal D. Rogers, Susan Sanchez, Julie H. Simpson, William S. Talbot, Douglas C. Wallace, Jill M. Weimer, Hugo J. Bellen
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 9 (2022)
Externí odkaz:
https://doaj.org/article/222ed46e51c14f58b45949b868d864dd
Autor:
Eliyahu Perl, Padmapriyadarshini Ravisankar, Manu E. Beerens, Lejla Mulahasanovic, Kelly Smallwood, Marion Bermúdez Sasso, Carina Wenzel, Thomas D. Ryan, Matej Komár, Kevin E. Bove, Calum A. MacRae, K. Nicole Weaver, Carlos E. Prada, Joshua S. Waxman
Publikováno v:
HGG Advances, Vol 3, Iss 3, Pp 100115- (2022)
Summary: Requirements for vesicle fusion within the heart remain poorly understood, despite the multitude of processes that necessitate proper intracellular trafficking within cardiomyocytes. Here, we show that Syntaxin 4 (STX4), a target-Soluble N-e
Externí odkaz:
https://doaj.org/article/69a4013e43b2410292ce66f8fe329a35
Autor:
Shinichi Goto, Keitaro Mahara, Lauren Beussink-Nelson, Hidehiko Ikura, Yoshinori Katsumata, Jin Endo, Hanna K. Gaggin, Sanjiv J. Shah, Yuji Itabashi, Calum A. MacRae, Rahul C. Deo
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Cardiac amyloidosis is difficult to identify, given low prevalence and similarity of the symptoms to more prevalent disorders. Here the authors present a multi-modality, artificial intelligence-enabled pipeline, that enables automated detection of ca
Externí odkaz:
https://doaj.org/article/0dd314b5edb84808bd06d6589d77bb90