Zobrazeno 1 - 10
of 127
pro vyhledávání: '"Calum Sutherland"'
Autor:
David Finlay, Satish Patel, Lorna M. Dickson, Natalia Shpiro, Rodolfo Marquez, Chris J. Rhodes, Calum Sutherland
Publikováno v:
BMC Molecular and Cell Biology, Vol 25, Iss 1, Pp 1-3 (2024)
Externí odkaz:
https://doaj.org/article/66b895b408324a3aa8c169cbefabfe87
Autor:
Chinmai Patibandla, Lidy van Aalten, Albena T. Dinkova-Kostova, Tadashi Honda, Antonio Cuadrado, Raquel Fernández-Ginés, Alison D. McNeilly, John D. Hayes, James Cantley, Calum Sutherland
Publikováno v:
Redox Biology, Vol 71, Iss , Pp 103117- (2024)
Accumulation of reactive oxygen species (i.e., oxidative stress) is a leading cause of beta cell dysfunction and apoptosis in diabetes. NRF2 (NF-E2 p45-related factor-2) regulates the adaptation to oxidative stress, and its activity is negatively reg
Externí odkaz:
https://doaj.org/article/174bdfaa05484649a9d4e82ff51fecbf
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-7 (2023)
Abstract Elraglusib (formerly 9-ING-41) is an ATP-competitive inhibitor of glycogen synthase kinase-3β (GSK3β) undergoing clinical trials for the treatment of various cancers including non-Hodgkin lymphoma (NHL). The drug reduces proliferation of s
Externí odkaz:
https://doaj.org/article/c6d05eb711b74cec9ec21be1f9bf415b
Autor:
Nicola Morrice, Susanne Vainio, Kirsi Mikkola, Lidy van Aalten, Jennifer R. Gallagher, Michael L.J. Ashford, Alison D. McNeilly, Rory J. McCrimmon, Alexandra Grosfeld, Patricia Serradas, Jukka Koffert, Ewan R. Pearson, Pirjo Nuutila, Calum Sutherland
Publikováno v:
Molecular Metabolism, Vol 77, Iss , Pp 101807- (2023)
Objectives: Metformin is the first line therapy recommended for type 2 diabetes. However, the precise mechanism of action remains unclear and up to a quarter of patients show some degree of intolerance to the drug, with a similar number showing poor
Externí odkaz:
https://doaj.org/article/60ff9417f6b94a40a6a38abc3d1becfc
Autor:
Shaun K. Bremner, Rebecca Berends, Alexandra Kaupisch, Jennifer Roccisana, Calum Sutherland, Nia J. Bryant, Gwyn W. Gould
Publikováno v:
PeerJ, Vol 11, p e15630 (2023)
The ability of insulin to stimulate glucose transport in muscle and fat cells is mediated by the regulated delivery of intracellular vesicles containing glucose transporter-4 (GLUT4) to the plasma membrane, a process known to be defective in disease
Externí odkaz:
https://doaj.org/article/5831b38646e94901aae3fc6ac5066021
Publikováno v:
BMJ Open, Vol 13, Iss 5 (2023)
Introduction Diabetes mellitus has increased in prevalence worldwide and is causing an increasing burden on health services. The best patient outcomes occur with early diagnosis to prevent health complications. Glycated haemoglobin (HbA1c) is used to
Externí odkaz:
https://doaj.org/article/0ba961b9728b4f768e0e85a74ea3e1c4
Autor:
Shaun K. Bremner, Woroud S. Al Shammari, Roderick S. Milligan, Brian D. Hudson, Calum Sutherland, Nia J. Bryant, Gwyn W. Gould
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Adipocytes play multiple roles in the regulation of glucose metabolism which rely on the regulation of membrane traffic. These include secretion of adipokines and serving as an energy store. Central to their energy storing function is the ability to
Externí odkaz:
https://doaj.org/article/6e5c53fc3d984273a7862c3a045bfb12
Autor:
Nicola Morrice, Lidy van Aalten, Alison McNeilly, Rory J. McCrimmon, Ewan R. Pearson, Rosamund Langston, Calum Sutherland
Publikováno v:
BMC Research Notes, Vol 13, Iss 1, Pp 1-6 (2020)
Abstract Objectives GLUT2 is a major facilitative glucose transporter, expressed from the SLC2A2 gene, with essential roles in the liver. Recent work in mice has shown that preventing Glut2 production in specific neuronal populations increases sugar-
Externí odkaz:
https://doaj.org/article/30f37bc9f6144beab305008ded44f606
Autor:
Changwei Chen, Jennifer R Gallagher, Jamie Tarlton, Lidy van Aalten, Susan E Bray, Michael L J Ashford, Rory J McCrimmon, Ewan R Pearson, Alison D McNeilly, Calum Sutherland
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0253533 (2021)
The biguanide, metformin, is the first-choice therapeutic agent for type-2 diabetes, although the mechanisms that underpin metformin clinical efficacy remain the subject of much debate, partly due to the considerable variation in patient response to
Externí odkaz:
https://doaj.org/article/9a24a180cc2645e98a6b2242015332ed
Autor:
Villo Muha, Ritchie Williamson, Rachel Hills, Alison D. McNeilly, Thomas G. McWilliams, Jana Alonso, Marianne Schimpl, Aneika C. Leney, Albert J. R. Heck, Calum Sutherland, Kevin D. Read, Rory J. McCrimmon, Simon P. Brooks, Daan M. F. van Aalten
Publikováno v:
Open Biology, Vol 9, Iss 11 (2019)
O-GlcNAcylation is an abundant post-translational modification in the nervous system, linked to both neurodevelopmental and neurodegenerative disease. However, the mechanistic links between these phenotypes and site-specific O-GlcNAcylation remain la
Externí odkaz:
https://doaj.org/article/9e64e5af2f29476f9e4eeb84d52a4cc3