Zobrazeno 1 - 10
of 1 041
pro vyhledávání: '"Calpains"'
Autor:
Laura Guarnaccia, Stefania Elena Navone, Laura Begani, Emanuela Barilla, Emanuele Garzia, Rolando Campanella, Monica Miozzo, Laura Fontana, Giovanni Alotta, Chiara Cordiglieri, Chiara Gaudino, Luigi Schisano, Antonella Ampollini, Laura Riboni, Marco Locatelli, Giovanni Marfia
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
IntroductionGlioblastoma IDH-wildtype (GBM) is the most malignant brain tumor in adults, with a poor prognosis of approximately 15 months after diagnosis. Most patients suffer from a recurrence in
Externí odkaz:
https://doaj.org/article/4ff36f582b654f4c962dae7e5c58ef3e
Autor:
J. Max Michel, Joshua S. Godwin, Daniel L. Plotkin, Paulo H. C. Mesquita, Mason C. McIntosh, Bradley A. Ruple, Cleiton A. Libardi, C. Brooks Mobley, Andreas N. Kavazis, Michael D. Roberts
Publikováno v:
Experimental Physiology, Vol 108, Iss 10, Pp 1268-1281 (2023)
Abstract We recently reported that vastus lateralis (VL) cross‐sectional area (CSA) increases after 7 weeks of resistance training (RT, 2 days/week), with declines occurring following 7 weeks of subsequent treadmill high‐intensity interval traini
Externí odkaz:
https://doaj.org/article/c6ef3fb0425541d9a24f209b571c30d2
Autor:
Martin Šafranek, Alain Shumbusho, Wenche Johansen, Júlia Šarkanová, Stanislav Voško, Boris Bokor, Ján Jásik, Viktor Demko
Publikováno v:
Frontiers in Plant Science, Vol 14 (2023)
Calpains are modulatory proteases that modify diverse cellular substrates and play essential roles in eukaryots. The best studied are animal cytosolic calpains. Here, we focus on enigmatic membrane-anchored calpains, their structural and functional f
Externí odkaz:
https://doaj.org/article/09ff405ffee54bcc96f6afaeec735daf
Autor:
M. Roths, M.A. Abeyta, B. Wilson, T.E. Rudolph, M.B. Hudson, R.P. Rhoads, L.H. Baumgard, J.T. Selsby
Publikováno v:
Journal of Dairy Science, Vol 106, Iss 8, Pp 5825-5834 (2023)
ABSTRACT: Heat stress (HS) markedly affects postabsorptive energetics and protein metabolism. Circulating urea nitrogen increases in multiple species during HS and it has been traditionally presumed to stem from increased skeletal muscle proteolysis;
Externí odkaz:
https://doaj.org/article/89e22ace766a48419aa312efde8aaf74
Autor:
Jeffrey Wang, Mohamed A. Ghonim, Salome V. Ibba, Hanh H. Luu, Yucel Aydin, Peter A. Greer, A. Hamid Boulares
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-14 (2022)
Abstract Background We reported that PARP-1 regulates genes whose products are crucial for asthma, in part, by controlling STAT6 integrity speculatively through a calpain-dependent mechanism. We wished to decipher the PARP-1/STAT6 relationship in the
Externí odkaz:
https://doaj.org/article/06e8d087c8bf469fa6f8d3b011c19b21
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Autor:
Li Zhang, Dong Zheng, Yuemei Yan, Yong Yu, Ruizhen Chen, Zheng Li, Peter A. Greer, Tianqing Peng, Qiang Wang
Publikováno v:
Arthritis Research & Therapy, Vol 24, Iss 1, Pp 1-18 (2022)
Abstract Background Calpains are a family of calcium-dependent thiol proteases that participate in a wide variety of biological activities. In our recent study, calpain is increased in the sera of scleroderma or systemic sclerosis (SSc). However, the
Externí odkaz:
https://doaj.org/article/1ebcfc8a05d54a55a7d606415c9baee8
Autor:
Chenlong Yi, Fangyu Chen, Rongrong Ma, Zhi Fu, Meijuan Song, Zhuan Zhang, Lingdi Chen, Xing Tang, Peng Lu, Ben Li, Qingfen Zhang, Qifeng Song, Guangzheng Zhu, Wei Wang, Qiang Wang, Xiaowei Wang
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
ObjectiveThe aim of this study was to test the hypothesis whether serum level of calpains could become a meaningful biomarker for diagnosis of acute lung injury (ALI) in clinical after cardiac surgery using cardiopulmonary bypass (CPB) technology.Met
Externí odkaz:
https://doaj.org/article/4ecbc536d08a476db44213497630487f
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Among posttranslational modifications, directed proteolytic processes have the strongest impact on protein integrity. They are executed by a variety of cellular machineries and lead to a wide range of molecular consequences. Compared to other forms o
Externí odkaz:
https://doaj.org/article/d73f02fd395b4896a1b7ffd8fc9ceb68
Autor:
Luis José Flores-Alvarez, Paola Jiménez-Alcántar, Alejandra Ochoa-Zarzosa, Joel E. López-Meza
Publikováno v:
Molecules, Vol 28, Iss 9, p 3661 (2023)
Cancer is a relevant health problem worldwide. In 2020, leukemias represented the 13th most commonly reported cancer cases worldwide but the 10th most likely to cause deaths. There has been a progressive increase in the efficacy of treatments for leu
Externí odkaz:
https://doaj.org/article/573957ff506b46e9882bfaf9c6c7e776