Preclinical development of a high affinity α-synuclein antibody, MEDI1341, that can enter the brain, sequester extracellular α-synuclein and attenuate α-synuclein spreading in vivo

Autor: Schofield, Darren J., Irving, Lorraine, Calo, Laura, Bogstedt, Anna, Rees, Gareth, Nuccitelli, Annalisa, Narwal, Rajesh, Petrone, Marcella, Roberts, Jennifer, Brown, Lee, Cusdin, Fiona, Dosanjh, Bhupinder, Lloyd, Christopher, Dobson, Claire, Gurrell, Ian, Fraser, Graham, McFarlane, Mary, Rockenstein, Edward, Spencer, Brian, Masliah, Eliezer, Spillantini, Maria Grazia, Tan, Keith, Billinton, Andrew, Vaughan, Tris, Chessell, Iain, Perkinton, Michael S.

Publikováno v: In Neurobiology of Disease December 2019 132

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Nanoscopic characterization of individual endogenous protein aggregates in human neuronal cells

Autor: Horrocks, Mathew, Whiten, Daniel R, Zuo, Yukun, Calo, Laura, Choi, Minee-liane, De, Suman, Wirthensohn, David C, Kundel, Franziska, Lee, Steven F, Dobson, Christopher, Gandhi, Sonia, Spillantini, Maria, Klenerman, David, Ranasinghe, Rohan T, Sanchez, Santiago E, Athauda, Dilan, Flagmeier, Patrick

Publikováno v: Horrocks, M, Whiten, D R, Zuo, Y, Calo, L, Choi, M, De, S, Wirthensohn, D C, Kundel, F, Lee, S F, Dobson, C, Gandhi, S, Spillantini, M, Klenerman, D, Ranasinghe, R T, Sanchez, S E, Athauda, D & Flagmeier, P 2018, ' Nanoscopic characterization of individual endogenous protein aggregates in human neuronal cells ', ChemBioChem . https://doi.org/10.1002/cbic.201800209

The aberrant misfolding and subsequent conversion of monomeric protein into amyloid aggregates characterizes many neurodegenerative disorders, including Parkinson’s and Alzheimer’s diseases. These aggregates are highly heterogeneous in structure,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3094::2592b6de1ac6eb0c9437d85304a62200
https://hdl.handle.net/20.500.11820/08644000-46a0-4712-bd75-ca8cb26be486

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Estudio comparativo de sistemas de rehabilitación en forjados de madera

Autor: Gayo Calo, Laura

Publikováno v: RUC. Repositorio da Universidade da Coruña
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[Resumen] El objetivo principal de este trabajo fin de grado es el estudio de diferentes tipos de sistemas de reparación y/o refuerzos en forjados de madera, para la consolidación y conservación de las estructuras realizadas con dicho material. El

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4dda34236f6ef57051054f8c055328bb
http://hdl.handle.net/2183/15254