Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Callum N. Watson"'
Autor:
Phillip L.R. Nicolson, Sophie H. Nock, Joshua Hinds, Lourdes Garcia-Quintanilla, Christopher W. Smith, Joana Campos, Alexander Brill, Jeremy A. Pike, Abdullah O. Khan, Natalie S. Poulter, Diedre M. Kavanagh, Stephanie Watson, Callum N. Watson, Hayley Clifford, Aarnoud P. Huissoon, Alice Y. Pollitt, Johannes A. Eble, Guy Pratt, Steve P. Watson, Craig E. Hughes
Publikováno v:
Haematologica, Vol 106, Iss 1 (2020)
Inhibitors of the tyrosine kinase Btk have been proposed as novel antiplatelet agents. In this study we show that low concentrations of the Btk inhibitor ibrutinib block CLEC-2-mediated activation and tyrosine phosphorylation including Syk and PLCγ2
Externí odkaz:
https://doaj.org/article/488fe4d4fc05448a940504d50e98e98e
Autor:
Callum N. Watson, Ghazala Begum, Emma Ashman, Daniella Thorn, Kamal M. Yakoub, Moustafa Al Hariri, Ali Nehme, Stefania Mondello, Firas Kobeissy, Antonio Belli, Valentina Di Pietro
Publikováno v:
Cells, Vol 11, Iss 1, p 163 (2022)
Alzheimer’s disease (AD) is the most common form of dementia globally; however, the aetiology of AD remains elusive hindering the development of effective therapeutics. MicroRNAs (miRNAs) are regulators of gene expression and have been of growing i
Externí odkaz:
https://doaj.org/article/ac1351a014ed437a96f031422989f482
Autor:
Marie-Blanche Onselaer, Alexander T. Hardy, Clare Wilson, Ximena Sanchez, Amir K. Babar, Jeanette L.C. Miller, Callum N. Watson, Stephanie K. Watson, Arkadiusz Bonna, Helen Philippou, Andrew B. Herr, Diego Mezzano, Robert A.S. Ariëns, Steve P. Watson
Publikováno v:
Blood Advances, Vol 1, Iss 19, Pp 1495-1504 (2017)
Abstract: Fibrin has recently been shown to activate platelets through the immunoglobulin receptor glycoprotein VI (GPVI). In the present study, we show that spreading of human platelets on fibrin is abolished in patients deficient in GPVI, confirmin
Externí odkaz:
https://doaj.org/article/1f1cbed05f4449a0b9bb085f298bf5e5
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Neurodegenerative diseases (NDs) are becoming increasingly prevalent in the world, with an aging population. In the last few decades, due to the devastating nature of these diseases, the research of biomarkers has become crucial to enable adequate tr
Externí odkaz:
https://doaj.org/article/d68874c02f0445a1ba71a103abc3a512
Autor:
Phillip L.R. Nicolson, Craig E. Hughes, Stephanie Watson, Sophie H. Nock, Alexander T. Hardy, Callum N. Watson, Samantha J. Montague, Hayley Clifford, Aarnoud P. Huissoon, Jean-Daniel Malcor, Mark R. Thomas, Alice Y. Pollitt, Michael G. Tomlinson, Guy Pratt, Steve P. Watson
Publikováno v:
Haematologica, Vol 103, Iss 12 (2018)
Ibrutinib and acalabrutinib are irreversible inhibitors of Bruton tyrosine kinase used in the treatment of B-cell malignancies. They bind irreversibly to cysteine 481 of Bruton tyrosine kinase, blocking autophosphorylation on tyrosine 223 and phospho
Externí odkaz:
https://doaj.org/article/2681f10f124a4014ac9e47570486c4e9
Autor:
Antonio Belli, Patrick O’Halloran, Simon Kemp, Ghazala Begum, David J Davies, Paolo Iliceto, Kamal M. Yakoub, Matthew Cross, David K. Menon, Valentina Di Pietro, Gabriella Candilera, Conor Bentley, Animesh Acharjee, Keith Stokes, Callum N. Watson
Publikováno v:
British Journal of Sports Medicine
Funder: Medical Research Council; FundRef: http://dx.doi.org/10.13039/501100000265
Funder: National Institute for Health Research; FundRef: http://dx.doi.org/10.13039/501100000272
Funder: Marker Diagnostics
Funder: Rugby Football Union
Funder: National Institute for Health Research; FundRef: http://dx.doi.org/10.13039/501100000272
Funder: Marker Diagnostics
Funder: Rugby Football Union
Autor:
Natalie S. Poulter, Joshua Hinds, Alexander Brill, Abdullah O. Khan, Sophie H. Nock, Phillip L R Nicolson, Craig E. Hughes, Joana Campos, Alice Y. Pollitt, Johannes A. Eble, Diedre M Kavanagh, Steve P. Watson, Callum N. Watson, Aarnoud Huissoon, Guy Pratt, Lourdes Garcia-Quintanilla, Christopher W Smith, Hayley Clifford, Stephanie Watson, Jeremy A. Pike
Publikováno v:
Haematologica. 106:208-219
Inhibitors of the tyrosine kinase Btk have been proposed as novel antiplatelet agents. In this study we show that low concentrations of the Btk inhibitor ibrutinib block CLEC-2-mediated activation and tyrosine phosphorylation including Syk and PLCγ2
Autor:
Aron K. Barbey, Emma Toman, Kamal M. Yakoub, Valentina Di Pietro, David Davies, Lauren Cooper, Zhangjie Su, Jon Bishop, Michael James Grey, Callum N. Watson, Vijay Sawlani, Mario Forcione, Antonio Belli, Conor Bentley, Douglas Hammond
Publikováno v:
BMJ Open
IntroductionSport-related concussion management remains a diagnostic dilemma to clinicians in all strata of care, coaching staff and players alike. The lack of objective diagnostic and prognostic biomarkers and over-reliance on subjective clinical as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::039cd820f0e6e955d4f772a1900936e5
https://ueaeprints.uea.ac.uk/id/eprint/71695/
https://ueaeprints.uea.ac.uk/id/eprint/71695/
Autor:
Kamal M, Yakoub, Patrick, O'Halloran, David J, Davies, Conor, Bentley, Callum N, Watson, Mario, Forcione, Ugo, Scarpa, Jonathan R B, Bishop, Emma, Toman, Douglas, Hammond, Matthew J, Cross, Keith A, Stokes, Simon P T, Kemp, David K, Menon, Valentina, Di Pietro, Antonio, Belli
Publikováno v:
BMJ Open
Introduction The diagnosis of mild traumatic brain injury or sports-related concussion is a challenge for all clinicians, players, coaches and parents involved in contact sports. Currently, there is no validated objective biomarker available to asses