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Whole-genome sequencing analysis of suicide deaths integrating brain-regulatory eQTLs data to identify risk loci and genes.

Autor: Han S; Department of Biomedical Informatics, University of Utah School of Medicine, Salt Lake City, UT, USA. seonggyun.han@utah.edu., DiBlasi E; Department of Psychiatry & Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City, UT, USA., Monson ET; Department of Psychiatry & Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City, UT, USA., Shabalin A; Department of Psychiatry & Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City, UT, USA., Ferris E; Department of Neurobiology, University of Utah School of Medicine, Salt Lake City, UT, USA., Chen D; Department of Psychiatry & Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City, UT, USA., Fraser A; Pedigree & Population Resource, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Yu Z; Pedigree & Population Resource, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Staley M; Office of the Medical Examiner, Utah Department of Health and Human Services, Salt Lake City, UT, USA., Callor WB; Office of the Medical Examiner, Utah Department of Health and Human Services, Salt Lake City, UT, USA., Christensen ED; Office of the Medical Examiner, Utah Department of Health and Human Services, Salt Lake City, UT, USA., Crockett DK; Clinical Analytics, Intermountain Health, Salt Lake City, UT, USA., Li QS; Neuroscience Therapeutic Area, Janssen Research & Development, LLC, Titusville, NJ, USA., Willour V; Department of Psychiatry, University of Iowa, Iowa City, IA, USA., Bakian AV; Department of Psychiatry & Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City, UT, USA., Keeshin B; Department of Psychiatry & Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Pediatrics, University of Utah, Salt Lake City, UT, USA., Docherty AR; Department of Psychiatry & Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City, UT, USA., Eilbeck K; Department of Biomedical Informatics, University of Utah School of Medicine, Salt Lake City, UT, USA., Coon H; Department of Psychiatry & Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.

Publikováno v: Molecular psychiatry [Mol Psychiatry] 2023 Sep; Vol. 28 (9), pp. 3909-3919. Date of Electronic Publication: 2023 Oct 04.

Extended familial risk of suicide death is associated with younger age at death and elevated polygenic risk of suicide.

Autor: Coon H; Department of Psychiatry & Huntsman Mental Health Institute, University of Utah, Salt Lake City, Utah, USA., Shabalin A; Department of Psychiatry & Huntsman Mental Health Institute, University of Utah, Salt Lake City, Utah, USA., Bakian AV; Department of Psychiatry & Huntsman Mental Health Institute, University of Utah, Salt Lake City, Utah, USA., DiBlasi E; Department of Psychiatry & Huntsman Mental Health Institute, University of Utah, Salt Lake City, Utah, USA., Monson ET; Department of Psychiatry & Huntsman Mental Health Institute, University of Utah, Salt Lake City, Utah, USA., Kirby A; Department of Occupational Therapy, University of Utah, Salt Lake City, Utah, USA., Chen D; Department of Psychiatry & Huntsman Mental Health Institute, University of Utah, Salt Lake City, Utah, USA., Fraser A; Pedigree & Population Resource, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA., Yu Z; Pedigree & Population Resource, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA., Staley M; Utah State Office of the Medical Examiner, Utah Department of Health, Salt Lake City, Utah, USA., Callor WB; Utah State Office of the Medical Examiner, Utah Department of Health, Salt Lake City, Utah, USA., Christensen ED; Utah State Office of the Medical Examiner, Utah Department of Health, Salt Lake City, Utah, USA., Crowell SE; Department of Psychology, University of Utah, Salt Lake City, Utah, USA., Gray D; Department of Psychiatry & Huntsman Mental Health Institute, University of Utah, Salt Lake City, Utah, USA., Crockett DK; Clinical Analytics, Intermountain Healthcare, Salt Lake City, Utah, USA., Li QS; Neuroscience Therapeutic Area, Janssen Research & Development LLC, Titusville, Utah, USA., Keeshin B; Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.; Primary Children's Hospital Center for Safe and Healthy Families, Salt Lake City, Utah, USA., Docherty AR; Department of Psychiatry & Huntsman Mental Health Institute, University of Utah, Salt Lake City, Utah, USA.

Publikováno v: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics [Am J Med Genet B Neuropsychiatr Genet] 2022 Apr; Vol. 189 (3-4), pp. 60-73. Date of Electronic Publication: 2022 Feb 24.

Rare protein-coding variants implicate genes involved in risk of suicide death.

Autor: DiBlasi E; Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, Utah, USA.; University of Utah Health, Huntsman Mental Health Institute, Salt Lake City, Utah, USA., Shabalin AA; Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, Utah, USA.; University of Utah Health, Huntsman Mental Health Institute, Salt Lake City, Utah, USA., Monson ET; Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, Utah, USA.; University of Utah Health, Huntsman Mental Health Institute, Salt Lake City, Utah, USA., Keeshin BR; Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, Utah, USA.; University of Utah Health, Huntsman Mental Health Institute, Salt Lake City, Utah, USA.; Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.; Safe and Healthy Families, Primary Children's Hospital, Intermountain Healthcare, Salt Lake City, Utah, USA., Bakian AV; Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, Utah, USA.; University of Utah Health, Huntsman Mental Health Institute, Salt Lake City, Utah, USA., Kirby AV; Department of Occupational & Recreational Therapies, University of Utah, Salt Lake City, Utah, USA., Ferris E; Department of Neurobiology & Anatomy, University of Utah School of Medicine, Salt Lake City, Utah, USA., Chen D; Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, Utah, USA.; University of Utah Health, Huntsman Mental Health Institute, Salt Lake City, Utah, USA., William N; Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, Utah, USA.; University of Utah Health, Huntsman Mental Health Institute, Salt Lake City, Utah, USA., Gaj E; Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, Utah, USA.; University of Utah Health, Huntsman Mental Health Institute, Salt Lake City, Utah, USA., Klein M; Health Sciences Center Core Research Facility, University of Utah, Salt Lake City, Utah, USA., Jerominski L; Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, Utah, USA.; University of Utah Health, Huntsman Mental Health Institute, Salt Lake City, Utah, USA., Callor WB; Utah State Office of the Medical Examiner, Utah Department of Health, Salt Lake City, Utah, USA., Christensen E; Utah State Office of the Medical Examiner, Utah Department of Health, Salt Lake City, Utah, USA., Smith KR; Pedigree & Population Resource, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA., Fraser A; Pedigree & Population Resource, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA., Yu Z; Pedigree & Population Resource, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA., Gray D; Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, Utah, USA.; University of Utah Health, Huntsman Mental Health Institute, Salt Lake City, Utah, USA., Camp NJ; Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA., Stahl EA; Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Li QS; Neuroscience Data Science, Janssen Research & Development LLC, Titusville, New Jersey, USA., Docherty AR; Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, Utah, USA.; University of Utah Health, Huntsman Mental Health Institute, Salt Lake City, Utah, USA.; Virginia Institute for Psychiatric & Behavioral Genetics, Virginia Commonwealth School of Medicine, Richmond, Virginia, USA., Coon H; Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, Utah, USA.; University of Utah Health, Huntsman Mental Health Institute, Salt Lake City, Utah, USA.

Publikováno v: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics [Am J Med Genet B Neuropsychiatr Genet] 2021 Dec; Vol. 186 (8), pp. 508-520. Date of Electronic Publication: 2021 May 27.

Genome-Wide Association Study of Suicide Death and Polygenic Prediction of Clinical Antecedents.

Autor: Docherty AR; Department of Psychiatry, University of Utah School of Medicine, Salt Lake City (Docherty, Shabalin, DiBlasi, Monson, Adkins, Bakian, Crowell, Chen, Darlington, Gray, Anderson, Jerominski, Coon); Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City (Docherty); Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond (Docherty, Bacanu); Department of Genetics and Genomic Sciences, Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York (Mullins); Department of Psychology, University of Utah, Salt Lake City (Crowell); Utah State Office of the Medical Examiner, Utah Department of Health, Salt Lake City (Callor, Christensen); Mental Illness Research, Education, and Clinical Center, Veterans Integrated Service Network 19, George E. Whalen Department of Veterans Affairs Medical Center, Salt Lake City (Gray); Department of Pediatrics, University of Utah School of Medicine, Salt Lake City (Keeshin); Health Sciences Center Core Research Facility, University of Utah, Salt Lake City (Klein); Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Hayward, Porteous, McIntosh); Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Porteous, McIntosh); and Janssen Research and Development, Neuroscience Therapeutic Area, Titusville, N.J. (Li)., Shabalin AA; Department of Psychiatry, University of Utah School of Medicine, Salt Lake City (Docherty, Shabalin, DiBlasi, Monson, Adkins, Bakian, Crowell, Chen, Darlington, Gray, Anderson, Jerominski, Coon); Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City (Docherty); Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond (Docherty, Bacanu); Department of Genetics and Genomic Sciences, Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York (Mullins); Department of Psychology, University of Utah, Salt Lake City (Crowell); Utah State Office of the Medical Examiner, Utah Department of Health, Salt Lake City (Callor, Christensen); Mental Illness Research, Education, and Clinical Center, Veterans Integrated Service Network 19, George E. Whalen Department of Veterans Affairs Medical Center, Salt Lake City (Gray); Department of Pediatrics, University of Utah School of Medicine, Salt Lake City (Keeshin); Health Sciences Center Core Research Facility, University of Utah, Salt Lake City (Klein); Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Hayward, Porteous, McIntosh); Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Porteous, McIntosh); and Janssen Research and Development, Neuroscience Therapeutic Area, Titusville, N.J. (Li)., DiBlasi E; Department of Psychiatry, University of Utah School of Medicine, Salt Lake City (Docherty, Shabalin, DiBlasi, Monson, Adkins, Bakian, Crowell, Chen, Darlington, Gray, Anderson, Jerominski, Coon); Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City (Docherty); Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond (Docherty, Bacanu); Department of Genetics and Genomic Sciences, Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York (Mullins); Department of Psychology, University of Utah, Salt Lake City (Crowell); Utah State Office of the Medical Examiner, Utah Department of Health, Salt Lake City (Callor, Christensen); Mental Illness Research, Education, and Clinical Center, Veterans Integrated Service Network 19, George E. Whalen Department of Veterans Affairs Medical Center, Salt Lake City (Gray); Department of Pediatrics, University of Utah School of Medicine, Salt Lake City (Keeshin); Health Sciences Center Core Research Facility, University of Utah, Salt Lake City (Klein); Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Hayward, Porteous, McIntosh); Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Porteous, McIntosh); and Janssen Research and Development, Neuroscience Therapeutic Area, Titusville, N.J. (Li)., Monson E; Department of Psychiatry, University of Utah School of Medicine, Salt Lake City (Docherty, Shabalin, DiBlasi, Monson, Adkins, Bakian, Crowell, Chen, Darlington, Gray, Anderson, Jerominski, Coon); Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City (Docherty); Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond (Docherty, Bacanu); Department of Genetics and Genomic Sciences, Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York (Mullins); Department of Psychology, University of Utah, Salt Lake City (Crowell); Utah State Office of the Medical Examiner, Utah Department of Health, Salt Lake City (Callor, Christensen); Mental Illness Research, Education, and Clinical Center, Veterans Integrated Service Network 19, George E. Whalen Department of Veterans Affairs Medical Center, Salt Lake City (Gray); Department of Pediatrics, University of Utah School of Medicine, Salt Lake City (Keeshin); Health Sciences Center Core Research Facility, University of Utah, Salt Lake City (Klein); Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Hayward, Porteous, McIntosh); Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Porteous, McIntosh); and Janssen Research and Development, Neuroscience Therapeutic Area, Titusville, N.J. (Li)., Mullins N; Department of Psychiatry, University of Utah School of Medicine, Salt Lake City (Docherty, Shabalin, DiBlasi, Monson, Adkins, Bakian, Crowell, Chen, Darlington, Gray, Anderson, Jerominski, Coon); Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City (Docherty); Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond (Docherty, Bacanu); Department of Genetics and Genomic Sciences, Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York (Mullins); Department of Psychology, University of Utah, Salt Lake City (Crowell); Utah State Office of the Medical Examiner, Utah Department of Health, Salt Lake City (Callor, Christensen); Mental Illness Research, Education, and Clinical Center, Veterans Integrated Service Network 19, George E. Whalen Department of Veterans Affairs Medical Center, Salt Lake City (Gray); Department of Pediatrics, University of Utah School of Medicine, Salt Lake City (Keeshin); Health Sciences Center Core Research Facility, University of Utah, Salt Lake City (Klein); Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Hayward, Porteous, McIntosh); Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Porteous, McIntosh); and Janssen Research and Development, Neuroscience Therapeutic Area, Titusville, N.J. (Li)., Adkins DE; Department of Psychiatry, University of Utah School of Medicine, Salt Lake City (Docherty, Shabalin, DiBlasi, Monson, Adkins, Bakian, Crowell, Chen, Darlington, Gray, Anderson, Jerominski, Coon); Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City (Docherty); Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond (Docherty, Bacanu); Department of Genetics and Genomic Sciences, Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York (Mullins); Department of Psychology, University of Utah, Salt Lake City (Crowell); Utah State Office of the Medical Examiner, Utah Department of Health, Salt Lake City (Callor, Christensen); Mental Illness Research, Education, and Clinical Center, Veterans Integrated Service Network 19, George E. Whalen Department of Veterans Affairs Medical Center, Salt Lake City (Gray); Department of Pediatrics, University of Utah School of Medicine, Salt Lake City (Keeshin); Health Sciences Center Core Research Facility, University of Utah, Salt Lake City (Klein); Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Hayward, Porteous, McIntosh); Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Porteous, McIntosh); and Janssen Research and Development, Neuroscience Therapeutic Area, Titusville, N.J. (Li)., Bacanu SA; Department of Psychiatry, University of Utah School of Medicine, Salt Lake City (Docherty, Shabalin, DiBlasi, Monson, Adkins, Bakian, Crowell, Chen, Darlington, Gray, Anderson, Jerominski, Coon); Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City (Docherty); Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond (Docherty, Bacanu); Department of Genetics and Genomic Sciences, Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York (Mullins); Department of Psychology, University of Utah, Salt Lake City (Crowell); Utah State Office of the Medical Examiner, Utah Department of Health, Salt Lake City (Callor, Christensen); Mental Illness Research, Education, and Clinical Center, Veterans Integrated Service Network 19, George E. Whalen Department of Veterans Affairs Medical Center, Salt Lake City (Gray); Department of Pediatrics, University of Utah School of Medicine, Salt Lake City (Keeshin); Health Sciences Center Core Research Facility, University of Utah, Salt Lake City (Klein); Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Hayward, Porteous, McIntosh); Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Porteous, McIntosh); and Janssen Research and Development, Neuroscience Therapeutic Area, Titusville, N.J. (Li)., Bakian AV; Department of Psychiatry, University of Utah School of Medicine, Salt Lake City (Docherty, Shabalin, DiBlasi, Monson, Adkins, Bakian, Crowell, Chen, Darlington, Gray, Anderson, Jerominski, Coon); Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City (Docherty); Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond (Docherty, Bacanu); Department of Genetics and Genomic Sciences, Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York (Mullins); Department of Psychology, University of Utah, Salt Lake City (Crowell); Utah State Office of the Medical Examiner, Utah Department of Health, Salt Lake City (Callor, Christensen); Mental Illness Research, Education, and Clinical Center, Veterans Integrated Service Network 19, George E. Whalen Department of Veterans Affairs Medical Center, Salt Lake City (Gray); Department of Pediatrics, University of Utah School of Medicine, Salt Lake City (Keeshin); Health Sciences Center Core Research Facility, University of Utah, Salt Lake City (Klein); Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Hayward, Porteous, McIntosh); Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Porteous, McIntosh); and Janssen Research and Development, Neuroscience Therapeutic Area, Titusville, N.J. (Li)., Crowell S; Department of Psychiatry, University of Utah School of Medicine, Salt Lake City (Docherty, Shabalin, DiBlasi, Monson, Adkins, Bakian, Crowell, Chen, Darlington, Gray, Anderson, Jerominski, Coon); Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City (Docherty); Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond (Docherty, Bacanu); Department of Genetics and Genomic Sciences, Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York (Mullins); Department of Psychology, University of Utah, Salt Lake City (Crowell); Utah State Office of the Medical Examiner, Utah Department of Health, Salt Lake City (Callor, Christensen); Mental Illness Research, Education, and Clinical Center, Veterans Integrated Service Network 19, George E. Whalen Department of Veterans Affairs Medical Center, Salt Lake City (Gray); Department of Pediatrics, University of Utah School of Medicine, Salt Lake City (Keeshin); Health Sciences Center Core Research Facility, University of Utah, Salt Lake City (Klein); Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Hayward, Porteous, McIntosh); Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Porteous, McIntosh); and Janssen Research and Development, Neuroscience Therapeutic Area, Titusville, N.J. (Li)., Chen D; Department of Psychiatry, University of Utah School of Medicine, Salt Lake City (Docherty, Shabalin, DiBlasi, Monson, Adkins, Bakian, Crowell, Chen, Darlington, Gray, Anderson, Jerominski, Coon); Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City (Docherty); Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond (Docherty, Bacanu); Department of Genetics and Genomic Sciences, Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York (Mullins); Department of Psychology, University of Utah, Salt Lake City (Crowell); Utah State Office of the Medical Examiner, Utah Department of Health, Salt Lake City (Callor, Christensen); Mental Illness Research, Education, and Clinical Center, Veterans Integrated Service Network 19, George E. Whalen Department of Veterans Affairs Medical Center, Salt Lake City (Gray); Department of Pediatrics, University of Utah School of Medicine, Salt Lake City (Keeshin); Health Sciences Center Core Research Facility, University of Utah, Salt Lake City (Klein); Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Hayward, Porteous, McIntosh); Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Porteous, McIntosh); and Janssen Research and Development, Neuroscience Therapeutic Area, Titusville, N.J. (Li)., Darlington TM; Department of Psychiatry, University of Utah School of Medicine, Salt Lake City (Docherty, Shabalin, DiBlasi, Monson, Adkins, Bakian, Crowell, Chen, Darlington, Gray, Anderson, Jerominski, Coon); Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City (Docherty); Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond (Docherty, Bacanu); Department of Genetics and Genomic Sciences, Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York (Mullins); Department of Psychology, University of Utah, Salt Lake City (Crowell); Utah State Office of the Medical Examiner, Utah Department of Health, Salt Lake City (Callor, Christensen); Mental Illness Research, Education, and Clinical Center, Veterans Integrated Service Network 19, George E. Whalen Department of Veterans Affairs Medical Center, Salt Lake City (Gray); Department of Pediatrics, University of Utah School of Medicine, Salt Lake City (Keeshin); Health Sciences Center Core Research Facility, University of Utah, Salt Lake City (Klein); Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Hayward, Porteous, McIntosh); Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Porteous, McIntosh); and Janssen Research and Development, Neuroscience Therapeutic Area, Titusville, N.J. (Li)., Callor WB; Department of Psychiatry, University of Utah School of Medicine, Salt Lake City (Docherty, Shabalin, DiBlasi, Monson, Adkins, Bakian, Crowell, Chen, Darlington, Gray, Anderson, Jerominski, Coon); Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City (Docherty); Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond (Docherty, Bacanu); Department of Genetics and Genomic Sciences, Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York (Mullins); Department of Psychology, University of Utah, Salt Lake City (Crowell); Utah State Office of the Medical Examiner, Utah Department of Health, Salt Lake City (Callor, Christensen); Mental Illness Research, Education, and Clinical Center, Veterans Integrated Service Network 19, George E. Whalen Department of Veterans Affairs Medical Center, Salt Lake City (Gray); Department of Pediatrics, University of Utah School of Medicine, Salt Lake City (Keeshin); Health Sciences Center Core Research Facility, University of Utah, Salt Lake City (Klein); Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Hayward, Porteous, McIntosh); Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Porteous, McIntosh); and Janssen Research and Development, Neuroscience Therapeutic Area, Titusville, N.J. (Li)., Christensen ED; Department of Psychiatry, University of Utah School of Medicine, Salt Lake City (Docherty, Shabalin, DiBlasi, Monson, Adkins, Bakian, Crowell, Chen, Darlington, Gray, Anderson, Jerominski, Coon); Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City (Docherty); Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond (Docherty, Bacanu); Department of Genetics and Genomic Sciences, Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York (Mullins); Department of Psychology, University of Utah, Salt Lake City (Crowell); Utah State Office of the Medical Examiner, Utah Department of Health, Salt Lake City (Callor, Christensen); Mental Illness Research, Education, and Clinical Center, Veterans Integrated Service Network 19, George E. Whalen Department of Veterans Affairs Medical Center, Salt Lake City (Gray); Department of Pediatrics, University of Utah School of Medicine, Salt Lake City (Keeshin); Health Sciences Center Core Research Facility, University of Utah, Salt Lake City (Klein); Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Hayward, Porteous, McIntosh); Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Porteous, McIntosh); and Janssen Research and Development, Neuroscience Therapeutic Area, Titusville, N.J. (Li)., Gray D; Department of Psychiatry, University of Utah School of Medicine, Salt Lake City (Docherty, Shabalin, DiBlasi, Monson, Adkins, Bakian, Crowell, Chen, Darlington, Gray, Anderson, Jerominski, Coon); Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City (Docherty); Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond (Docherty, Bacanu); Department of Genetics and Genomic Sciences, Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York (Mullins); Department of Psychology, University of Utah, Salt Lake City (Crowell); Utah State Office of the Medical Examiner, Utah Department of Health, Salt Lake City (Callor, Christensen); Mental Illness Research, Education, and Clinical Center, Veterans Integrated Service Network 19, George E. Whalen Department of Veterans Affairs Medical Center, Salt Lake City (Gray); Department of Pediatrics, University of Utah School of Medicine, Salt Lake City (Keeshin); Health Sciences Center Core Research Facility, University of Utah, Salt Lake City (Klein); Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Hayward, Porteous, McIntosh); Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Porteous, McIntosh); and Janssen Research and Development, Neuroscience Therapeutic Area, Titusville, N.J. (Li)., Keeshin B; Department of Psychiatry, University of Utah School of Medicine, Salt Lake City (Docherty, Shabalin, DiBlasi, Monson, Adkins, Bakian, Crowell, Chen, Darlington, Gray, Anderson, Jerominski, Coon); Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City (Docherty); Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond (Docherty, Bacanu); Department of Genetics and Genomic Sciences, Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York (Mullins); Department of Psychology, University of Utah, Salt Lake City (Crowell); Utah State Office of the Medical Examiner, Utah Department of Health, Salt Lake City (Callor, Christensen); Mental Illness Research, Education, and Clinical Center, Veterans Integrated Service Network 19, George E. Whalen Department of Veterans Affairs Medical Center, Salt Lake City (Gray); Department of Pediatrics, University of Utah School of Medicine, Salt Lake City (Keeshin); Health Sciences Center Core Research Facility, University of Utah, Salt Lake City (Klein); Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Hayward, Porteous, McIntosh); Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Porteous, McIntosh); and Janssen Research and Development, Neuroscience Therapeutic Area, Titusville, N.J. (Li)., Klein M; Department of Psychiatry, University of Utah School of Medicine, Salt Lake City (Docherty, Shabalin, DiBlasi, Monson, Adkins, Bakian, Crowell, Chen, Darlington, Gray, Anderson, Jerominski, Coon); Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City (Docherty); Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond (Docherty, Bacanu); Department of Genetics and Genomic Sciences, Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York (Mullins); Department of Psychology, University of Utah, Salt Lake City (Crowell); Utah State Office of the Medical Examiner, Utah Department of Health, Salt Lake City (Callor, Christensen); Mental Illness Research, Education, and Clinical Center, Veterans Integrated Service Network 19, George E. Whalen Department of Veterans Affairs Medical Center, Salt Lake City (Gray); Department of Pediatrics, University of Utah School of Medicine, Salt Lake City (Keeshin); Health Sciences Center Core Research Facility, University of Utah, Salt Lake City (Klein); Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Hayward, Porteous, McIntosh); Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Porteous, McIntosh); and Janssen Research and Development, Neuroscience Therapeutic Area, Titusville, N.J. (Li)., Anderson JS; Department of Psychiatry, University of Utah School of Medicine, Salt Lake City (Docherty, Shabalin, DiBlasi, Monson, Adkins, Bakian, Crowell, Chen, Darlington, Gray, Anderson, Jerominski, Coon); Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City (Docherty); Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond (Docherty, Bacanu); Department of Genetics and Genomic Sciences, Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York (Mullins); Department of Psychology, University of Utah, Salt Lake City (Crowell); Utah State Office of the Medical Examiner, Utah Department of Health, Salt Lake City (Callor, Christensen); Mental Illness Research, Education, and Clinical Center, Veterans Integrated Service Network 19, George E. Whalen Department of Veterans Affairs Medical Center, Salt Lake City (Gray); Department of Pediatrics, University of Utah School of Medicine, Salt Lake City (Keeshin); Health Sciences Center Core Research Facility, University of Utah, Salt Lake City (Klein); Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Hayward, Porteous, McIntosh); Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Porteous, McIntosh); and Janssen Research and Development, Neuroscience Therapeutic Area, Titusville, N.J. (Li)., Jerominski L; Department of Psychiatry, University of Utah School of Medicine, Salt Lake City (Docherty, Shabalin, DiBlasi, Monson, Adkins, Bakian, Crowell, Chen, Darlington, Gray, Anderson, Jerominski, Coon); Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City (Docherty); Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond (Docherty, Bacanu); Department of Genetics and Genomic Sciences, Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York (Mullins); Department of Psychology, University of Utah, Salt Lake City (Crowell); Utah State Office of the Medical Examiner, Utah Department of Health, Salt Lake City (Callor, Christensen); Mental Illness Research, Education, and Clinical Center, Veterans Integrated Service Network 19, George E. Whalen Department of Veterans Affairs Medical Center, Salt Lake City (Gray); Department of Pediatrics, University of Utah School of Medicine, Salt Lake City (Keeshin); Health Sciences Center Core Research Facility, University of Utah, Salt Lake City (Klein); Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Hayward, Porteous, McIntosh); Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Porteous, McIntosh); and Janssen Research and Development, Neuroscience Therapeutic Area, Titusville, N.J. (Li)., Hayward C; Department of Psychiatry, University of Utah School of Medicine, Salt Lake City (Docherty, Shabalin, DiBlasi, Monson, Adkins, Bakian, Crowell, Chen, Darlington, Gray, Anderson, Jerominski, Coon); Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City (Docherty); Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond (Docherty, Bacanu); Department of Genetics and Genomic Sciences, Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York (Mullins); Department of Psychology, University of Utah, Salt Lake City (Crowell); Utah State Office of the Medical Examiner, Utah Department of Health, Salt Lake City (Callor, Christensen); Mental Illness Research, Education, and Clinical Center, Veterans Integrated Service Network 19, George E. Whalen Department of Veterans Affairs Medical Center, Salt Lake City (Gray); Department of Pediatrics, University of Utah School of Medicine, Salt Lake City (Keeshin); Health Sciences Center Core Research Facility, University of Utah, Salt Lake City (Klein); Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Hayward, Porteous, McIntosh); Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Porteous, McIntosh); and Janssen Research and Development, Neuroscience Therapeutic Area, Titusville, N.J. (Li)., Porteous DJ; Department of Psychiatry, University of Utah School of Medicine, Salt Lake City (Docherty, Shabalin, DiBlasi, Monson, Adkins, Bakian, Crowell, Chen, Darlington, Gray, Anderson, Jerominski, Coon); Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City (Docherty); Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond (Docherty, Bacanu); Department of Genetics and Genomic Sciences, Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York (Mullins); Department of Psychology, University of Utah, Salt Lake City (Crowell); Utah State Office of the Medical Examiner, Utah Department of Health, Salt Lake City (Callor, Christensen); Mental Illness Research, Education, and Clinical Center, Veterans Integrated Service Network 19, George E. Whalen Department of Veterans Affairs Medical Center, Salt Lake City (Gray); Department of Pediatrics, University of Utah School of Medicine, Salt Lake City (Keeshin); Health Sciences Center Core Research Facility, University of Utah, Salt Lake City (Klein); Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Hayward, Porteous, McIntosh); Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Porteous, McIntosh); and Janssen Research and Development, Neuroscience Therapeutic Area, Titusville, N.J. (Li)., McIntosh A; Department of Psychiatry, University of Utah School of Medicine, Salt Lake City (Docherty, Shabalin, DiBlasi, Monson, Adkins, Bakian, Crowell, Chen, Darlington, Gray, Anderson, Jerominski, Coon); Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City (Docherty); Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond (Docherty, Bacanu); Department of Genetics and Genomic Sciences, Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York (Mullins); Department of Psychology, University of Utah, Salt Lake City (Crowell); Utah State Office of the Medical Examiner, Utah Department of Health, Salt Lake City (Callor, Christensen); Mental Illness Research, Education, and Clinical Center, Veterans Integrated Service Network 19, George E. Whalen Department of Veterans Affairs Medical Center, Salt Lake City (Gray); Department of Pediatrics, University of Utah School of Medicine, Salt Lake City (Keeshin); Health Sciences Center Core Research Facility, University of Utah, Salt Lake City (Klein); Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Hayward, Porteous, McIntosh); Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Porteous, McIntosh); and Janssen Research and Development, Neuroscience Therapeutic Area, Titusville, N.J. (Li)., Li Q; Department of Psychiatry, University of Utah School of Medicine, Salt Lake City (Docherty, Shabalin, DiBlasi, Monson, Adkins, Bakian, Crowell, Chen, Darlington, Gray, Anderson, Jerominski, Coon); Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City (Docherty); Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond (Docherty, Bacanu); Department of Genetics and Genomic Sciences, Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York (Mullins); Department of Psychology, University of Utah, Salt Lake City (Crowell); Utah State Office of the Medical Examiner, Utah Department of Health, Salt Lake City (Callor, Christensen); Mental Illness Research, Education, and Clinical Center, Veterans Integrated Service Network 19, George E. Whalen Department of Veterans Affairs Medical Center, Salt Lake City (Gray); Department of Pediatrics, University of Utah School of Medicine, Salt Lake City (Keeshin); Health Sciences Center Core Research Facility, University of Utah, Salt Lake City (Klein); Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Hayward, Porteous, McIntosh); Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Porteous, McIntosh); and Janssen Research and Development, Neuroscience Therapeutic Area, Titusville, N.J. (Li)., Coon H; Department of Psychiatry, University of Utah School of Medicine, Salt Lake City (Docherty, Shabalin, DiBlasi, Monson, Adkins, Bakian, Crowell, Chen, Darlington, Gray, Anderson, Jerominski, Coon); Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City (Docherty); Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond (Docherty, Bacanu); Department of Genetics and Genomic Sciences, Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York (Mullins); Department of Psychology, University of Utah, Salt Lake City (Crowell); Utah State Office of the Medical Examiner, Utah Department of Health, Salt Lake City (Callor, Christensen); Mental Illness Research, Education, and Clinical Center, Veterans Integrated Service Network 19, George E. Whalen Department of Veterans Affairs Medical Center, Salt Lake City (Gray); Department of Pediatrics, University of Utah School of Medicine, Salt Lake City (Keeshin); Health Sciences Center Core Research Facility, University of Utah, Salt Lake City (Klein); Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Hayward, Porteous, McIntosh); Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Porteous, McIntosh); and Janssen Research and Development, Neuroscience Therapeutic Area, Titusville, N.J. (Li).

Publikováno v: The American journal of psychiatry [Am J Psychiatry] 2020 Oct 01; Vol. 177 (10), pp. 917-927.