Výsledky vyhledávání - "Callie, Heaton"

Akademický článek

Partnership of I-ACT for children (US) and European pediatric clinical trial networks to facilitate pediatric clinical trials

Autor: Eva Degraeuwe, Collin Hovinga, Annelies De Maré, Ricardo M. Fernandes, Callie Heaton, Lieve Nuytinck, Laura Persijn, Ann Raes, Johan Vande Walle, Mark A. Turner

Publikováno v: Frontiers in Pediatrics, Vol 12 (2024)

Background/aimsDue to a lack of standard pediatric prescribing information, medicines are often used in a dosage form or for an indication that has not been investigated in children. Pediatric clinical trial research networks aim to facilitate the ti

Externí odkaz: https://doaj.org/article/f30308b70eeb4806b9cfd55b246f4b4c

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A multicenter phase 1/2 study investigating the safety, pharmacokinetics, pharmacodynamics and efficacy of a small molecule antimetabolite, RX-3117, plus nab-paclitaxel in pancreatic adenocarcinoma

Autor: Nafisa Burhani, Hani M. Babiker, Emad Elquza, Andrea J. Bullock, Ely Benaim, Allyson J. Ocean, Lee G. Hicks, Peter J. Schlegel, Christine B. Peterson, Daruka Mahadevan, Mitesh J. Borad, Callie Heaton

Publikováno v: Investigational New Drugs. 40:81-90

Background RX-3117 is an oral small molecule antimetabolite, cyclopentyl pyrimidyl nucleoside that is activated by cancer cells over-expressing uridine cytidine kinase 2 (UCK2). Single agent RX-3117 demonstrated efficacy in a phase I trial in patient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8841b5475e5beb9575ab758350b71ace
https://doi.org/10.1007/s10637-021-01164-9

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A multicenter phase 1/2 study investigating the safety, pharmacokinetics, pharmacodynamics and efficacy of a small molecule antimetabolite, RX-3117, plus nab-paclitaxel in pancreatic adenocarcinoma

Autor: Hani, Babiker, Peter J, Schlegel, Lee G, Hicks, Andrea J, Bullock, Nafisa, Burhani, Daruka, Mahadevan, Emad, Elquza, Mitesh J, Borad, Ely, Benaim, Christine, Peterson, Callie, Heaton, Allyson J, Ocean

Publikováno v: Investigational new drugs. 40(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::651202fed5992602007b5c919335cd35
https://pubmed.ncbi.nlm.nih.gov/34417914

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RX-3117 (fluorocyclopentenyl cytosine): a novel specific antimetabolite for selective cancer treatment

Autor: Richard J. Honeywell, Young Bok Lee, Godefridus J. Peters, Christine B. Peterson, Julie Poore, Dzjemma Sarkisjan, Callie Heaton, Ely Benaim, Elisa Giovannetti, Btissame El Hassouni, Beatrice Balboni, Deog Joong Kim

Publikováno v: Expert Opinion on Investigational Drugs, 28(4), 311-322. Taylor and Francis Ltd.
Balboni, B, el Hassouni, B, Honeywell, R J, Sarkisjan, D, Giovannetti, E, Poore, J, Heaton, C, Peterson, C, Benaim, E, Lee, Y B, Kim, D J & Peters, G J 2019, ' RX-3117 (fluorocyclopentenyl cytosine): a novel specific antimetabolite for selective cancer treatment ', Expert Opinion on Investigational Drugs, vol. 28, no. 4, pp. 311-322 . https://doi.org/10.1080/13543784.2019.1583742

Introduction: RX-3117 is an oral, small molecule cytidine analog anticancer agent with an improved pharmacological profile relative to gemcitabine and other nucleoside analogs. The agent has excellent activity against various cancer cell lines and xe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de49d19ad4125048d6f79e1a3e85708a
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85063098464&origin=inward

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Results of a phase II study to evaluate the safety and efficacy of RX-0201 in combination with everolimus in subjects with metastatic renal cell carcinoma (mRCC)

Autor: Neeraj Agarwal, Callie Heaton, Srinath Sundararajan, Scott T. Tagawa, Parminder Singh, Ely Benaim, Sumanta K. Pal, Sanjay Goel, Christine B. Peterson, Gurkamal Chatta, Richard C. Lauer

Publikováno v: Journal of Clinical Oncology. 37:646-646

646 Background: RX-0201 is a novel 20-mer oligonucleotide that binds to mRNA coding for AKT-1, preventing AKT-1 expression and limiting the amount of downstream p-AKT. In vitro RX-0201, in combination with everolimus, additively inhibited Caki-1 cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a8113ebf943cd0a3e9ce434ede75d341
https://doi.org/10.1200/jco.2019.37.7_suppl.646

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A phase I/II study of RX-3117, an oral antimetabolite nucleoside, in combination with nab-paclitaxel (nab-pac) as first-line treatment of metastatic pancreatic cancer (met-PC): Preliminary results

Autor: Lee G. Hicks, Peter J. Schlegel, Hani M. Babiker, Andrea J. Bullock, Nafisa Burhani, Callie Heaton, Christine B. Peterson, Ely Benaim, Allyson J. Ocean

Publikováno v: Journal of Clinical Oncology. 37:420-420

420 Background: RX-3117 is an oral small molecule antimetabolite, cyclopentyl pyrimidyl nucleoside that is activated by cancer-enriched uridine cytidine kinase 2. Single agent RX-3117 has demonstrated efficacy in a phase III single agent clinical stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2e70a6ae1a28574f86e31de1f9e86b45
https://doi.org/10.1200/jco.2019.37.4_suppl.420

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Abstract CT114: Phase Ib/II Study of RX-0201, a novel AKT-1 antisense, combined with everolimus to treat metastatic clear cell renal carcinoma - Phase Ib results

Autor: Reza Mazhari, Sumanta K. Pal, Scott T. Tagawa, Gurkamal Chatta, Sanjay Goel, Neeraj Agarwal, Ely Benaim, Callie Heaton

Publikováno v: Cancer Research. 76:CT114-CT114

Background: RX-0201, a novel, oligonucleotide that binds native AKT-1 mRNA, prevents downstream phosphorylation to p-AKT. RX-0201, in combination with everolimus, additively inhibited Caki-1 cell growth in vitro and is in development for the treatmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::96eac9eaab68b62348e3de1c9cdf27f3
https://doi.org/10.1158/1538-7445.am2016-ct114

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Results from a phase 1b/2 study of RX-0201, a novel AKT-1 antisense, combined with everolimus to treat metastatic clear cell renal carcinoma

Autor: Scott T. Tagawa, Sumanta K. Pal, Gurkamal Chatta, Ely Benaim, Reza Mazhari, Callie Heaton, Neeraj Agarwal, Sanjay Goel

Publikováno v: Journal of Clinical Oncology. 34:2559-2559

2559Background: RX-0201 is a novel, oligonucleotide that binds native AKT-1 mRNA, preventing downstream phosphorylation to p-AKT. RX-0201, in combination with everolimus, to treat metastatic clear cell renal carcinoma. In vitro RX-0201, in combinatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::16279fbfeafb156649770a443593a6ef
https://doi.org/10.1200/jco.2016.34.15_suppl.2559

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Most Closely HLA-Matched Allogeneic Virus Specific Cytotoxic T-Lymphocytes (CTL) to Treat Persistent Reactivation or Infection With Adenovirus, CMV and EBV After Hemopoietic Stem Cell Transplantation (HSCT)

Autor: Neena Kapoor, Adrian P. Gee, Bambi Grilley, Elizabeth J. Shpall, Cliona M. Rooney, Malcolm K. Brenner, Catherine M. Bollard, Adam Mendizabal, Joseph H. Antin, Ann M. Leen, Callie Heaton, Helen E. Heslop, Paul Szabolcs

Publikováno v: Biology of Blood and Marrow Transplantation. 17(2):S151-S152

Abstract 829 Adoptive transfer of donor-derived cytotoxic T lymphocytes (CTLs) can reconstitute antiviral immunity to Epstein-Barr virus (EBV), cytomegalovirus (CMV) and adenovirus in recipients of allogeneic hemopoietic stem cell transplantation (HS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66172b6311711068f3c61226d230b986

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