Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Calli M. Lear-Rooney"'
Autor:
Jeffrey W. Froude, Calli M. Lear-Rooney, Nazli Araghi, Sergey Shulenin, Julia E. Biggins, Andrew S. Herbert, Hong Vu, Kelly L. Warfield, Yong Wang, Patrick Lau, John M. Dye, Ariel S. Wirchnianski, Katie A. Howell, Frederick W. Holtsberg, Robin Douglas, Zhen-Yong Keck, Steven K. H. Foung, M. Javad Aman, Sven Enterlein, Pamela J. Glass
Publikováno v:
Journal of Virology. 90:279-291
Filoviruses cause highly lethal viral hemorrhagic fever in humans and nonhuman primates. Current immunotherapeutic options for filoviruses are mostly specific to Ebola virus (EBOV), although other members of Filoviridae such as Sudan virus (SUDV), Bu
Autor:
Calli M. Lear-Rooney, Christopher M. Coleman, Lisa M. Johansen, Reed F. Johnson, Jason Kindrachuk, Gene G. Olinger, Lisa E. Hensley, Michael R. Holbrook, Matthew B. Frieman, Thiagarajan Venkataraman, Peter B. Jahrling, Pamela J. Glass, Monique Laidlaw, Julie Dyall, Brit J. Hart
Publikováno v:
Antimicrobial Agents and Chemotherapy
Outbreaks of emerging infections present health professionals with the unique challenge of trying to select appropriate pharmacologic treatments in the clinic with little time available for drug testing and development. Typically, clinicians are left
Autor:
M. Javad Aman, Hong Vu, Robin Douglas, Sergey Shulenin, John M. Dye, Marnie L. Fusco, Sonal J. Patel, Andrew S. Herbert, Jonathan R. Lai, Marcus M. Karim, Erica Ollmann Saphire, Katie A. Howell, Bronwyn M. Gunn, Kelly L. Warfield, Ariel S. Wirchnianski, Galit Alter, Elisabeth K. Nyakatura, Larry Zeitlin, Julia C. Frei, Frederick W. Holtsberg, Calli M. Lear-Rooney, Jeffrey W. Froude, Pamela J. Glass
The unprecedented 2014-2015 Ebola virus disease (EVD) outbreak in West Africa has highlighted the need for effective therapeutics against filoviruses. Monoclonal antibody (MAb) cocktails have shown great potential as EVD therapeutics; however, the ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29ee88021ba53814208117ee432b454d
https://europepmc.org/articles/PMC4702560/
https://europepmc.org/articles/PMC4702560/
Autor:
Elizabeth Varhegyi, Lisa M. Johansen, Han Cheng, Zheng W. Chen, Gene G. Olinger, Lijun Rong, Calli M. Lear-Rooney
Filoviruses, consisting of Ebola virus (EBOV) and Marburg virus (MARV), are among the most lethal infectious threats to mankind. Infections by these viruses can cause severe hemorrhagic fevers in humans and nonhuman primates with high mortality rates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58384aaf12d74b99e641c3765728b874
https://europepmc.org/articles/PMC4577884/
https://europepmc.org/articles/PMC4577884/
Autor:
Gene G. Olinger, Judith M. White, Lisa M. Johansen, Pamela J. Glass, Jill M. Grenier, Elizabeth A. Nelson, Charles J. Shoemaker, Calli M. Lear-Rooney, Laura T. Pierce, Lisa Evans DeWald, Andrea Stossel, James A. Simmons, Hassan Pajouhesh, Sue E. Delos, Benjamin G. Hoffstrom, Lisa E. Hensley, Joseph Lehar
Publikováno v:
Science translational medicine. 7(290)
Currently, no approved therapeutics exist to treat or prevent infections induced by Ebola viruses, and recent events have demonstrated an urgent need for rapid discovery of new treatments. Repurposing approved drugs for emerging infections remains a
Autor:
Aura R. Garrison, John W. Huggins, Jason Paragas, Lauren R.H. Krumpe, Calli M. Lear-Rooney, Carrie J. Saucedo, Mike Bray, Barbara Giomarelli, James B. McMahon, Maura Rose, Barry R. O'Keefe, Gene G. Olinger, Srikanth Yellayi
The cyanobacterial lectin scytovirin (SVN) binds with high affinity to mannose-rich oligosaccharides on the envelope glycoprotein (GP) of a number of viruses, blocking entry into target cells. In this study, we assessed the ability of SVN to bind to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45501d3134d8fd213c202cc6ca0739c2
https://europepmc.org/articles/PMC4258435/
https://europepmc.org/articles/PMC4258435/
Autor:
Mark S. Lever, Jamie Pettitt, Gene G. Olinger, Sophie J. Smither, Calli M. Lear-Rooney, Julia E. Biggins
Publikováno v:
Journal of virological methods. 193(2)
Two common methods of quantifying filovirus infectivity, a plaque assay and 50% cell culture infectious dose (TCID50) endpoint dilution assay, were compared. The two assays were performed side by side using the same virus stock sample to determine th