Short-Term, Intermittent Fasting Induces Long-Lasting Gut Health and TOR-Independent Lifespan Extension

Autor: Catterson, James H, Khericha, Mobina, Dyson, Miranda C, Vincent, Alec J, Callard, Rebecca, Haveron, Steven M, Rajasingam, Arjunan, Ahmad, Mumtaz, Partridge, Linda

Publikováno v: Curr Biol

Intermittent fasting (IF) can improve function and health during aging in laboratory model organisms, but the mechanisms at work await elucidation. We subjected fruit flies (Drosophila melanogaster) to varying degrees of IF and found that just one mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::5b81824687f9e76975821075f694e5ad
https://hdl.handle.net/21.11116/0000-0004-71FD-0

Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer's disease:Keap1 as a therapeutic target for Alzheimer's Disease

Autor: Kerr, Fiona, Sofola-Adesakin, Oyinkan, Ivanov, Dobril, Gatliff, Jemma, Gomez Perez-Nievas, Beatriz, Bertrand, Helene, Martinez, Pedro, Callard, Rebecca, Snoeren, Inge, Cocheme, Helena, Adcott, Jennifer, Khericha, Mobina, Castillo-Quan, Jorge, Noble, Wendy, Wells, Geoffrey, Thornton, Janet, Partridge, Linda

Publikováno v: Kerr, F, Sofola-Adesakin, O, Ivanov, D, Gatliff, J, Gomez Perez-Nievas, B, Bertrand, H, Martinez, P, Callard, R, Snoeren, I, Cocheme, H, Adcott, J, Khericha, M, Castillo-Quan, J, Noble, W, Wells, G, Thornton, J & Partridge, L 2017, ' Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer's disease : Keap1 as a therapeutic target for Alzheimer's Disease ', PL o S Genetics, vol. 13, no. 3, e1006593 . https://doi.org/10.1371/journal.pgen.1006593

Nrf2, a transcriptional activator of cell protection genes, is an attractive therapeutic target for the prevention of neurodegenerative diseases, including Alzheimer’s disease (AD). Current Nrf2 activators, however, may exert toxicity and pathway o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2761::2e5da4df1a83fffbc938799806c1ca76
https://kclpure.kcl.ac.uk/en/publications/eb48b61d-983a-49a8-8967-3c6cdbce8e2e

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