Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Calina Glynn"'
Autor:
Anastasie Mate de Gerando, Anita Khasnavis, Lindsay A. Welikovitch, Harshil Bhavsar, Calina Glynn, Noe Quittot, Romain Perbet, Bradley T. Hyman
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-17 (2024)
Abstract Pathological tau fibrils in progressive supranuclear palsy, frontotemporal dementia, chronic traumatic encephalopathy, and Alzheimer’s disease each have unique conformations, and post-translational modifications that correlate with unique
Externí odkaz:
https://doaj.org/article/265517a1d8dd4be28b9789a9cb30adf7
Autor:
Calina Glynn, Evelyn Hernandez, Marcus Gallagher-Jones, Jennifer Miao, Christina J. Sigurdson, Jose A. Rodriguez
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Sequence variation in the β2α2 loop, residues 165-175 of the mammalian prion protein (PrP), influences its structure. To better understand the consequences of sequence variation in this region of the protein, we biochemically and biophysically inte
Externí odkaz:
https://doaj.org/article/df68122640d24f5eb2f52b9f253f4704
Autor:
Chih-Te Zee, Calina Glynn, Marcus Gallagher-Jones, Jennifer Miao, Carlos G. Santiago, Duilio Cascio, Tamir Gonen, Michael R. Sawaya, Jose A. Rodriguez
Publikováno v:
IUCrJ, Vol 6, Iss 2, Pp 197-205 (2019)
The ice-nucleation protein InaZ from Pseudomonas syringae contains a large number of degenerate repeats that span more than a quarter of its sequence and include the segment GSTSTA. Ab initio structures of this repeat segment, resolved to 1.1 Å by m
Externí odkaz:
https://doaj.org/article/5443cf5d4b124bdfa45fe063f3a9fe3e
Autor:
Logan S. Richards, Maria D. Flores, Claudia Millán, Calina Glynn, Chih-Te Zee, Michael R. Sawaya, Marcus Gallagher-Jones, Rafael J. Borges, Isabel Usón, Jose A. Rodriguez
Publikováno v:
ACS Bio & Med Chem Au. 3:201-210
Autor:
Anastasie Mate de Gerando, Lindsay A Welikovitch, Anita Khasnavis, Caitlin Commins, Calina Glynn, Joshua E Chun, Romain Perbet, Bradley T Hyman
Insoluble fibrillar tau, the primary constituent of neurofibrillary tangles, has traditionally been thought to be the biologically active, toxic form of tau mediating neurodegeneration in Alzheimer disease. More recent studies have implicated soluble
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f3fa63ff1d4356fbd355dade343809f
https://doi.org/10.1101/2023.03.28.534418
https://doi.org/10.1101/2023.03.28.534418
Autor:
Joanna M Cooper, Aurelien Lathuiliere, John Dickson, Calina Glynn, Zhanyun Fan, Cameron Donahue, Mary Migliorini, Bradley T. Hyman, Dudley K Strickland
Publikováno v:
Alzheimer's & Dementia. 18
Autor:
Logan S. Richards, Rafael J. Borges, Jose A. Rodriguez, Calina Glynn, Marcus Gallagher-Jones, Chih-Te Zee, Claudia Millán, Maria D. Flores, Michael R. Sawaya, Isabel Usón
Microcrystal electron diffraction (MicroED) is transforming the visualization of molecules from nanocrystals, rendering their three-dimensional atomic structures from previously unamenable samples. Peptidic structures determined by MicroED include na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74fed878855908af4f3f9369c1960adb
https://doi.org/10.1101/2021.09.13.459692
https://doi.org/10.1101/2021.09.13.459692
Autor:
Gaurav Bhardwaj, Jacob O’Connor, Stephen Rettie, Yen-Hua Huang, Theresa A. Ramelot, Vikram Khipple Mulligan, Gizem Gokce Alpkilic, Jonathan Palmer, Asim K. Bera, Matthew J. Bick, Maddalena Di Piazza, Xinting Li, Parisa Hosseinzadeh, Timothy W. Craven, Roberto Tejero, Anna Lauko, Ryan Choi, Calina Glynn, Linlin Dong, Robert Griffin, Wesley C. van Voorhis, Jose Rodriguez, Lance Stewart, Gaetano T. Montelione, David Craik, David Baker
Publikováno v:
Cell. 185:3520-3532.e26
We use computational design coupled with experimental characterization to systematically investigate the design principles for macrocycle membrane permeability and oral bioavailability. We designed 184 6-12 residue macrocycles with a wide range of pr
Autor:
Calina Glynn, Jose A. Rodriguez
Publikováno v:
Emerging Topics in Life Sciences
Emerging topics in life sciences, vol 3, iss 4
Emerging topics in life sciences, vol 3, iss 4
Structural biology is in the midst of a revolution fueled by faster and more powerful instruments capable of delivering orders of magnitude more data than their predecessors. This increased pace in data gathering introduces new experimental and compu
Autor:
Catharine Shipps, Sophia M. Yi, Nikhil S. Malvankar, H. Ray Kelly, Calina Glynn, David Eisenberg, Dennis Vu, Peter Dahl, Michael R. Sawaya, David R. Boyer, Victor S. Batista
Publikováno v:
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 2
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 2
Proteins are commonly known to transfer electrons over distances limited to a few nanometers. However, many biological processes require electron transport over far longer distances. For example, soil and sediment bacteria transport electrons, over h