Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Calin C. Guet"'
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
In Gram negative bacteria, the multiple antibiotic resistance or mar operon, is known to control the expression of multi-drug efflux genes that protect bacteria from a wide range of drugs. As many different chemical compounds can induce this operon,
Externí odkaz:
https://doaj.org/article/416071487e0f4678a4a17d4124080d6a
Autor:
Kathrin Tomasek, Alexander Leithner, Ivana Glatzova, Michael S Lukesch, Calin C Guet, Michael Sixt
Publikováno v:
eLife, Vol 11 (2022)
A key attribute of persistent or recurring bacterial infections is the ability of the pathogen to evade the host’s immune response. Many Enterobacteriaceae express type 1 pili, a pre-adapted virulence trait, to invade host epithelial cells and esta
Externí odkaz:
https://doaj.org/article/d82a091bbe6042118c8d19a2e745b23b
Autor:
Mato Lagator, Srdjan Sarikas, Magdalena Steinrueck, David Toledo-Aparicio, Jonathan P Bollback, Calin C Guet, Gašper Tkačik
Publikováno v:
eLife, Vol 11 (2022)
Predicting function from sequence is a central problem of biology. Currently, this is possible only locally in a narrow mutational neighborhood around a wildtype sequence rather than globally from any sequence. Using random mutant libraries, we devel
Externí odkaz:
https://doaj.org/article/50f68b595e8143fc96311c7d7b58db73
Autor:
Anna Nagy-Staron, Kathrin Tomasek, Caroline Caruso Carter, Elisabeth Sonnleitner, Bor Kavčič, Tiago Paixão, Calin C Guet
Publikováno v:
eLife, Vol 10 (2021)
Gene expression levels are influenced by multiple coexisting molecular mechanisms. Some of these interactions such as those of transcription factors and promoters have been studied extensively. However, predicting phenotypes of gene regulatory networ
Externí odkaz:
https://doaj.org/article/df2487ed4b874c41970c4d8b7a0c9edd
Since bacteria lack a nucleus, the location of mRNA molecules is determined by the different characteristics of the encoded proteins, and the transcriptome is spatially arranged into cytosolic and membrane-associated mRNA. While translation of membra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be23c14d0c278f224755a9bf0da35430
https://doi.org/10.1101/2022.12.16.520495
https://doi.org/10.1101/2022.12.16.520495
Autor:
Isabella Tomanek, Calin C. Guet
Copy-number and point mutations form the basis for most evolutionary novelty through the process of gene duplication and divergence. While a plethora of genomic sequence data reveals the long-term fate of diverging coding sequences and their cis-regu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3e88e52a40eca4a2f079a19ccfe6eb8
https://doi.org/10.1101/2022.08.11.503575
https://doi.org/10.1101/2022.08.11.503575
Publikováno v:
Molecular microbiology. 86(6)
We examine whether the Escherichia coli chromosome is folded into a self-adherent nucleoprotein complex, or alternately is a confined but otherwise unconstrained self-avoiding polymer. We address this through in vivo visualization, using an inducible
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fca979055b9fdc8202b717da3e0526de
https://pubmed.ncbi.nlm.nih.gov/23078263
https://pubmed.ncbi.nlm.nih.gov/23078263
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Single cell growth rate variability has been difficult to understand. Here, the authors apply a generalization of flux balance analysis to single cells based on maximum entropy modeling, and find that growth rate fluctuations of E. coli reflect metab
Externí odkaz:
https://doaj.org/article/047a842e2a584521b3b1c31d7ce5b03a
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Individual bacteria interact with each other and their environment to produce population-level patterns of gene expression. Here the authors use an automated platform combined with optogenetic feedback to manipulate population behaviors through dynam
Externí odkaz:
https://doaj.org/article/1fadea4a2a1341e78b4f878004e369cc