Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Calin C Guet"'
Autor:
Kathrin Tomasek, Alexander Leithner, Ivana Glatzova, Michael S Lukesch, Calin C Guet, Michael Sixt
Publikováno v:
eLife, Vol 11 (2022)
A key attribute of persistent or recurring bacterial infections is the ability of the pathogen to evade the host’s immune response. Many Enterobacteriaceae express type 1 pili, a pre-adapted virulence trait, to invade host epithelial cells and esta
Externí odkaz:
https://doaj.org/article/d82a091bbe6042118c8d19a2e745b23b
Autor:
Mato Lagator, Srdjan Sarikas, Magdalena Steinrueck, David Toledo-Aparicio, Jonathan P Bollback, Calin C Guet, Gašper Tkačik
Publikováno v:
eLife, Vol 11 (2022)
Predicting function from sequence is a central problem of biology. Currently, this is possible only locally in a narrow mutational neighborhood around a wildtype sequence rather than globally from any sequence. Using random mutant libraries, we devel
Externí odkaz:
https://doaj.org/article/50f68b595e8143fc96311c7d7b58db73
Autor:
Anna Nagy-Staron, Kathrin Tomasek, Caroline Caruso Carter, Elisabeth Sonnleitner, Bor Kavčič, Tiago Paixão, Calin C Guet
Publikováno v:
eLife, Vol 10 (2021)
Gene expression levels are influenced by multiple coexisting molecular mechanisms. Some of these interactions such as those of transcription factors and promoters have been studied extensively. However, predicting phenotypes of gene regulatory networ
Externí odkaz:
https://doaj.org/article/df2487ed4b874c41970c4d8b7a0c9edd
Since bacteria lack a nucleus, the location of mRNA molecules is determined by the different characteristics of the encoded proteins, and the transcriptome is spatially arranged into cytosolic and membrane-associated mRNA. While translation of membra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be23c14d0c278f224755a9bf0da35430
https://doi.org/10.1101/2022.12.16.520495
https://doi.org/10.1101/2022.12.16.520495
Autor:
Isabella Tomanek, Calin C. Guet
Copy-number and point mutations form the basis for most evolutionary novelty through the process of gene duplication and divergence. While a plethora of genomic sequence data reveals the long-term fate of diverging coding sequences and their cis-regu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3e88e52a40eca4a2f079a19ccfe6eb8
https://doi.org/10.1101/2022.08.11.503575
https://doi.org/10.1101/2022.08.11.503575
Autor:
Isabella Tomanek, Călin C Guet
Publikováno v:
eLife, Vol 11 (2022)
Together, copy-number and point mutations form the basis for most evolutionary novelty, through the process of gene duplication and divergence. While a plethora of genomic data reveals the long-term fate of diverging coding sequences and their cis-re
Externí odkaz:
https://doaj.org/article/086639d4c29a43a1a28769db8e7c282d
Publikováno v:
Molecular microbiology. 86(6)
We examine whether the Escherichia coli chromosome is folded into a self-adherent nucleoprotein complex, or alternately is a confined but otherwise unconstrained self-avoiding polymer. We address this through in vivo visualization, using an inducible
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 7, p e1007168 (2019)
Mathematical models have been used successfully at diverse scales of biological organization, ranging from ecology and population dynamics to stochastic reaction events occurring between individual molecules in single cells. Generally, many biologica
Externí odkaz:
https://doaj.org/article/59602513deeb4bcaa85bac1e1874c492
Autor:
Waqas N Chaudhry, Maroš Pleška, Nilang N Shah, Howard Weiss, Ingrid C McCall, Justin R Meyer, Animesh Gupta, Călin C Guet, Bruce R Levin
Publikováno v:
PLoS Biology, Vol 16, Iss 8, p e2005971 (2018)
In experimental cultures, when bacteria are mixed with lytic (virulent) bacteriophage, bacterial cells resistant to the phage commonly emerge and become the dominant population of bacteria. Following the ascent of resistant mutants, the densities of
Externí odkaz:
https://doaj.org/article/807252dd11a348919f49f026a58af619