Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Caleb William Holyoke"'
Autor:
Yewande T. Henry, Wenming Zhang, Ming Xu, Daniel Cordova, Thomas F. Pahutski, James D. Barry, Stephen Frederick Mccann, My-Hanh Thi Tong, Chen Yuzhong, Caleb William Holyoke, Twyla A. Briddell, George Philip Lahm, Kenneth A. Hughes, Robert M. Leighty
We have discovered mesoionic pyrido[1,2-a]pyrimidinones as a novel class of insecticides and identified compounds such as dicloromezotiaz for development. During optimization of this area, we also discovered that mesoionic pyrido[1,2-a]pyrimidinones
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf2d31854a29671b1e62ef7be56ef9b0
https://doi.org/10.1016/b978-0-12-821035-2.00010-3
https://doi.org/10.1016/b978-0-12-821035-2.00010-3
Autor:
Daniel Cordova, Robert F. Dietrich, Luís A. F. Teixeira, Laurie A. Christianson, James D. Barry, Robert M. Leighty, Rejane M. Smith, My-Hanh Thi Tong, James J. Rauh, Wenming Zhang, Vineet Singh, Kenneth A. Hughes, Caleb William Holyoke, John Lawrence Andreassi, George Philip Lahm, Eric A. Benner, Daniel R. Vincent, Thomas F. Pahutski
Publikováno v:
Pest Management Science. 73:796-806
BACKGROUND As the world population grows towards 9 billion by 2050, it is projected that food production will need to increase by 60%. A critical part of this growth includes the safe and effective use of insecticides to reduce the estimated 20–49%
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::576eac96b73b5f6c890442dfd22692d3
https://doi.org/10.1002/ps.4496
https://doi.org/10.1002/ps.4496
Autor:
Thomas F. Pahutski, Caleb William Holyoke, Twyla A. Briddell, Ming Xu, James D. Barry, Daniel Cordova, My-Hanh Thi Tong, Stephen Frederick Mccann, Yewande T. Henry, Wenming Zhang, Kenneth A. Hughes, Robert M. Leighty, Chen Yuzhong, George Philip Lahm
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:911-917
A novel class of mesoionic pyrido[1,2-a]pyrimidinones has been discovered with exceptional insecticidal activity controlling a number of insect species. In this communication, we report the part of the optimization program that led to the identificat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5ea850baf0fb21fc2e4134e0a48257f
https://doi.org/10.1016/j.bmcl.2017.01.002
https://doi.org/10.1016/j.bmcl.2017.01.002
Autor:
Robert M. Leighty, Kenneth A. Hughes, George Philip Lahm, Ming Xu, Stephen Frederick Mccann, James D. Barry, Thomas F. Pahutski, Vineet Singh, My-Hanh Thi Tong, Wenming Zhang, Daniel R. Vicent, Caleb William Holyoke, Twyla A. Briddell, Yewande T. Henry, Daniel Cordova
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:16-20
A novel class of mesoionic pyrido[1,2-a]pyrimidinones has been discovered with exceptional insecticidal activity controlling a number of insect species. In this communication, we report the part of the optimization program which led to the discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d61512da92996b4a747d10aa46201eb7
https://doi.org/10.1016/j.bmcl.2016.11.042
https://doi.org/10.1016/j.bmcl.2016.11.042
Autor:
Robert M. Leighty, Eric A. Benner, Wenming Zhang, Daniel Cordova, Jason C. Hamm, Daniel R. Vincent, Mark E. Schroeder, Thomas F. Pahutski, Caleb William Holyoke
Publikováno v:
Insect Biochemistry and Molecular Biology. 74:32-41
Triflumezopyrim, a newly commercialized molecule from DuPont Crop Protection, belongs to the novel class of mesoionic insecticides. This study characterizes the biochemical and physiological action of this novel insecticide. Using membranes from the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95d08efb257bb9318fc0d97ad80ab027
https://doi.org/10.1016/j.ibmb.2016.04.008
https://doi.org/10.1016/j.ibmb.2016.04.008
Autor:
George Philip Lahm, Eric A. Benner, Daniel Cordova, Kathleen Joraski, Michael J. Mahaffey, Caleb William Holyoke, Ben K. Smith, Rejane M. Smith, Jeffrey Keith Long, My-Hahn Tong, Mark E. Schroeder, Thomas F. Pahutski, James D. Barry, Ty Wagerle, Ming Xu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:3001-3006
Isoxazoline insecticides have been shown to be potent blockers of insect GABA receptors with excellent activity on a broad pest range, including Lepidoptera and Hemiptera. Herein we report on the synthesis, biological activity and mode-of-action for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79032c07cd410e045b848bd1c29425ee
https://doi.org/10.1016/j.bmcl.2013.03.031
https://doi.org/10.1016/j.bmcl.2013.03.031
Autor:
Stephen Frederick Mccann, Daniel Cordova, My-Hanh Thi Tong, James D. Barry, Wenming Zhang, Robert M. Leighty, Daniel R. Vincent, Ming Xu, Kenneth A. Hughes, Twyla A. Briddell, Caleb William Holyoke, George Philip Lahm, Thomas F. Pahutski
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(22)
A novel class of mesoionic pyrido[1,2-a]pyrimidinones has been discovered with exceptional insecticidal activity controlling a number of insect species, particularly hemiptera and lepidoptera. Mode-of-action studies showed that they act on nicotinic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9d468182c11b5021d9f68b4c65fe7ed
https://pubmed.ncbi.nlm.nih.gov/27777010
https://pubmed.ncbi.nlm.nih.gov/27777010
Autor:
Caleb William Holyoke, Daniel Cordova, Rejane M. Smith, Robert F. Dietrich, Robert F. Daly, Mark E. Schroeder, Thomas F. Pahutski, My-Hanh Thi Tong, James J. Rauh, Laurie A. Christianson, Daniel R. Vincent, Wenming Zhang, George Philip Lahm, Eric A. Benner, Robert M. Leighty
Publikováno v:
ACS Symposium Series ISBN: 9780841231023
ACS Symposium Series
ACS Symposium Series
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f65e091ba4394a1ab600d5f47c981f3f
https://doi.org/10.1021/bk-2015-1204.ch026
https://doi.org/10.1021/bk-2015-1204.ch026
Autor:
Steven D. Buckingham, James J. Rauh, Daniel Cordova, David B. Sattelle, Eric A. Benner, Michael E. Schnee, Richard T. Roush, Caleb William Holyoke, Michael L Hutton, Donglin Bai, Michael Henry Howard, Alain Hamon
Publikováno v:
British Journal of Pharmacology. 121:1496-1505
1. The radiolabelled bicyclic dinitrile, [3H]-3,3-bis-trifluoromethyl-bicyclo[2.2.1]heptane-2,2-dicarbonitrile ([3H]-BIDN), exhibited, specific binding of high affinity to membranes of the southern corn rootworm (Diabrotica undecimpunctata howardi) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2312fae64b54538da261fc7748bf4a8
https://doi.org/10.1038/sj.bjp.0701215
https://doi.org/10.1038/sj.bjp.0701215
Autor:
Caleb William Holyoke, Steven D. Buckingham, Yasuhito Shirai, Howard A. Baylis, David B. Sattelle, Alastair M. Hosie
Publikováno v:
Neuroscience Letters. 189:1-4
The actions of picrotoxinin and four of its analogues were tested on a Drosophila melanogaster homo-oligomeric GABA (gamma-aminobutyric acid) receptor formed when RDL (resistance to dieldrin) subunits were expressed in Xenopus oocytes. In agreement w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be1727b4bbcf5aa0c1a29bab9d8667da
https://doi.org/10.1016/0304-3940(95)11432-v
https://doi.org/10.1016/0304-3940(95)11432-v