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of 8
pro vyhledávání: '"Caleb Shearrow"'
Autor:
Zachary D Crees, Caleb Shearrow, Leo Lin, Jennifer Girard, Kavin Arasi, Aayush Bhoraskar, Joseph Berei, Adam Eckburg, Austin D. Anderson, Christian Garcia, Ariana Munger, Sunil Palani, Thomas J Smith, Shylendra B Sreenivassappa, Connie Vitali, Odile David, Neelu Puri
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 12 (2020)
Background: EGFR/c-Met activation/amplification and co-expression, mTOR upregulation/activation, and Akt/Wnt signaling upregulation have been individually associated with more aggressive disease and characterized as potential prognostic markers for l
Externí odkaz:
https://doaj.org/article/8c227a1782da4256ae9803b9ba799ade
Autor:
Odile David, Zachary Crees, Austin D. Anderson, Kavin Arasi, Ariana Munger, Lin Leo S, Caleb Shearrow, Christian Garcia, Thomas J. Smith, Neelu Puri, Shylendra Sreenivassappa, Aayush Bhoraskar, Sunil Palani, Jennifer Girard, Adam Eckburg, Connie Vitali, Joseph Berei
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 12 (2020)
Therapeutic Advances in Medical Oncology
Therapeutic Advances in Medical Oncology
Background:EGFR/c-Met activation/amplification and co-expression, mTOR upregulation/activation, and Akt/Wnt signaling upregulation have been individually associated with more aggressive disease and characterized as potential prognostic markers for lu
Autor:
Zechary Rios, Luke Wojdyla, Neelu Puri, Srijayaprakash B. Uppada, Caleb Shearrow, Amanda L Stone, Joseph T. Devito, Gregory M. Botting, Zachary Crees, Kymberly Harrington, Jennifer Girard
Publikováno v:
Current Pharmaceutical Design. 20:6422-6437
Cancer is a leading cause of death worldwide and an estimated 1 in 4 deaths in the United States is due to cancer. Despite recent advances in cancer treatment, adverse effects related to cancer therapy remain a limiting factor for many patients. The
Autor:
Caleb Shearrow, Andrew Nowak, Neelu Puri, Shylendra Sreenivassappa, Aayush Bhoraskar, Zachary Crees, Connie Vitali, Kavin Asari, Lin Leo S, Odile David, Gagan Chhabra
Publikováno v:
Journal of Thoracic Oncology. 11:S286-S287
Autor:
Connie Vitali, Lin Leo S, Odile David, Andrew Nowak, Neelu Puri, Shylendra Sreenivassappa, Aayush Bhoraskar, Kavin Arasi, Zachary Crees, Bonnie Sheu, Caleb Shearrow, Gagan Chhabra, Jennifer Girard
Publikováno v:
Cancer Research. 76:4755-4755
NSCLC tumors acquire resistance to EGFR-TKIs, and studies have suggested that co-localization of c-MET and EGFR may be a modality of acquired resistance. Upregulation of alternative signaling pathways such as Wnt or mTOR have been shown to be associa
Autor:
Luke Wojdyla, Zechary Rios, Ceyda Bertram, Caleb Shearrow, Srijayaprakash B. Uppada, Gregory M. Botting, Neelu Puri
Publikováno v:
Journal of Postgenomics Drug & Biomarker Development.
Traditional chemotherapy is the first treatment option for the majority of cancer patients, but due to harsh and toxic side effects, more targeted therapies are needed. T-oligo is an oligonucleotide homologous to the 3’ overhang of the telomere. It
Autor:
Andrew Nowak, Ceyda Bertram, Lin Leo S, Sunil Palani, Neelu Puri, Jennifer Girard, Kavin Arasi, Kymberly Harrington, Bonnie Sheu, Caleb Shearrow, Zachary Crees
Publikováno v:
Cancer Research. 75:743-743
Lung cancer is projected to be the number one cause of cancer mortality in the United States in 2014. Therapies such as tyrosine kinase inhibitors (TKIs) have been developed to treat non-small cell lung cancer (NSCLC), which accounts for 80-85% of al
Autor:
Jennifer Girard, Neelu Puri, Kymberly Harrington, Caleb Shearrow, Gregory M. Botting, Kavin Arasi, Zachary Crees
Publikováno v:
Cancer Research. 74:1838-1838
Current EGFR/c-Met tyrosine kinase inhibitor (TKI) combination therapies are shown to be susceptible to acquired resistance in the majority of NSCLC patients. To understand how cells develop EGFR/c-Met TKI resistance, we use three model NSCLC cell li