Whole microbe arrays accurately predict interactions and overall antimicrobial activity of galectin-8 toward distinct strains of Streptococcus pneumoniae

Autor: Shang-Chuen Wu, Hau-Ming Jan, Mary L. Vallecillo-Zúniga, Matthew F. Rathgeber, Caleb S. Stowell, Kaleb L. Murdock, Kashyap R. Patel, Hirotomo Nakahara, Carter J. Stowell, Moon H. Nahm, Connie M. Arthur, Richard D. Cummings, Sean R. Stowell

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)

Abstract Microbial glycan microarrays (MGMs) populated with purified microbial glycans have been used to define the specificity of host immune factors toward microbes in a high throughput manner. However, a limitation of such arrays is that glycan pr

Externí odkaz: https://doaj.org/article/c4280ad7b7c745f8a5a8f62ba788f3bd

Evaluating Therapeutic Activity of Galectin-1 in Sarcolemma Repair of Skeletal Muscle

Autor: Mary L, Vallecillo-Zúniga, Matthew, Rathgeber, Daniel, Poulson, Braden, Kartchner, Jacob, Luddington, Hailie, Gill, Spencer, Hayes, Matthew, Teynor, Caleb S, Stowell, Connie M, Arthur, Sean R, Stowell, Pam M, Van Ry

Publikováno v: Methods in molecular biology (Clifton, N.J.). 2442

Galectin-1 is a small (14.5 kDa) multifunctional protein with cell-cell and cell-ECM adhesion due to interactions with the carbohydrate recognition domain (CRD). In two types of muscular dystrophies, this lectin protein has shown therapeutic properti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b62ad1d90aeee1ab7b43b3e78e581356
https://pubmed.ncbi.nlm.nih.gov/35320552

The Sweet-Side of Leukocytes: Galectins as Master Regulators of Neutrophil Function

Autor: Richard D. Cummings, Marcelo Dias-Baruffi, Birk Evavold, Nourine A. Kamili, Connie M. Arthur, Brian S. Robinson, Caleb S. Stowell, Ethan Roback, Mary L. Vallecillo-Zúniga, Pam M. Van Ry, Sean R. Stowell

Publikováno v: Frontiers in Immunology, Vol 10 (2019)
Frontiers in Immunology
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Among responders to microbial invasion, neutrophils represent one of the earliest and perhaps most important factors that contribute to initial host defense. Effective neutrophil immunity requires their rapid mobilization to the site of infection, wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cb3ac1d9cc7d03448d8ac63e26a1519
https://pubmed.ncbi.nlm.nih.gov/31440233