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pro vyhledávání: '"Caleb R. Perez"'
Autor:
Caleb R. Perez, Michele De Palma
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Dendritic cells (DCs) have been explored as a promising strategy for cancer immunotherapy. In this Perspective, the authors discuss the different types of DCs and their therapeutic potential in the context of vaccines for personalized cancer therapy.
Externí odkaz:
https://doaj.org/article/36a03cc25943495c9a8a8fbc19153abb
Publikováno v:
Cell Reports, Vol 35, Iss 1, Pp 108960- (2021)
Summary: The tumor microenvironment encompasses an intertwined ensemble of both transformed cancer cells and non-transformed host cells, which together establish a signaling network that regulates tumor progression. By conveying both homo- and hetero
Externí odkaz:
https://doaj.org/article/f1879f53e6e2420f8c5c61d00a9e30d8
Autor:
Khloe S. Gordon, Taeyoon Kyung, Caleb R. Perez, Patrick V. Holec, Azucena Ramos, Angela Q. Zhang, Yash Agarwal, Yunpeng Liu, Catherine E. Koch, Alina Starchenko, Brian A. Joughin, Douglas A. Lauffenburger, Darrell J. Irvine, Michael T. Hemann, Michael E. Birnbaum
Publikováno v:
Nature Biomedical Engineering. 7:599-602
Autor:
Khloe S. Gordon, Taeyoon Kyung, Caleb R. Perez, Patrick V. Holec, Azucena Ramos, Angela Q. Zhang, Yash Agarwal, Yunpeng Liu, Catherine E. Koch, Alina Starchenko, Brian A. Joughin, Douglas A. Lauffenburger, Darrell J. Irvine, Michael T. Hemann, Michael E. Birnbaum
Publikováno v:
Nat Biomed Eng
The immunostimulatory intracellular domains (ICDs) of chimaeric antigen receptors (CARs) are essential for converting antigen recognition into antitumoural function. Although there are many possible combinations of ICDs, almost all current CARs rely
Autor:
Michele De Palma, Caleb R. Perez
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Nature Communications
Nature Communications
At the interface between the innate and adaptive immune system, dendritic cells (DCs) play key roles in tumour immunity and hold a hitherto unrealized potential for cancer immunotherapy. Here we review the role of distinct DC subsets in the tumour mi
Publikováno v:
Cell Reports
Cell Reports, Vol 35, Iss 1, Pp 108960-(2021)
Cell Reports, Vol 35, Iss 1, Pp 108960-(2021)
Summary: The tumor microenvironment encompasses an intertwined ensemble of both transformed cancer cells and non-transformed host cells, which together establish a signaling network that regulates tumor progression. By conveying both homo- and hetero
Autor:
Joshua A. Gustafson, Bryan Kaehr, Suzie H. Pun, Ian I. Cardle, Ashley Wilson, Michael C. Jensen, Yu-Shen Lin, Caleb R. Perez, Brynn R Olden
Publikováno v:
Advanced Healthcare Materials. 8:1801188
Biomaterial properties that modulate T cell activation, growth, and differentiation are of significant interest in the field of cellular immunotherapy manufacturing. In this work, we present a new platform technology that allows for the modulation of