Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Caleb Pitcairn"'
Autor:
Alice Drobny, Fanni Annamária Boros, Denise Balta, Susy Prieto Huarcaya, Deniz Caylioglu, Niyeti Qazi, Julia Vandrey, Yanni Schneider, Jan Philipp Dobert, Caleb Pitcairn, Joseph Robert Mazzulli, Friederike Zunke
Publikováno v:
Translational Neurodegeneration, Vol 12, Iss 1, Pp 1-21 (2023)
Abstract Background Lysosomal dysfunction has been implicated in a number of neurodegenerative diseases such as Parkinson’s disease (PD). Various molecular, clinical and genetic studies have highlighted a central role of lysosomal pathways and prot
Externí odkaz:
https://doaj.org/article/6c6cd4d73e7a4b1eb9f3766ea635e4f6
Publikováno v:
Neurobiology of Disease, Vol 122, Iss , Pp 72-82 (2019)
The finding that mutations in the Gaucher's Disease (GD) gene GBA1 are a strong risk factor for Parkinson's Disease (PD) has allowed for unique insights into pathophysiology centered on disruption of the autophagic-lysosomal pathway. Protein aggregat
Externí odkaz:
https://doaj.org/article/e9ed5cbfb2d74792a62fd261d07a66e6
Publikováno v:
The Journal of Neuroscience. 43:2615-2629
Macroautophagy is a catabolic process that coordinates with lysosomes to degrade aggregation-prone proteins and damaged organelles. Loss of macroautophagy preferentially affects neuron viability and is associated with age-related neurodegeneration. W
Autor:
Kristina Fredriksen, Stefanos Aivazidis, Karan Sharma, Kevin J. Burbidge, Caleb Pitcairn, Friederike Zunke, Eilrayna Gelyana, Joseph R. Mazzulli
Publikováno v:
Proc Natl Acad Sci U S A
GBA1 mutations that encode lysosomal β-glucocerebrosidase (GCase) cause the lysosomal storage disorder Gaucher disease (GD) and are strong risk factors for synucleinopathies, including Parkinson’s disease and Lewy body dementia. Only a subset of s
Autor:
Pia Steensland, Annika Thorsell, Riccardo Barchiesi, Mikaela Wendel Hansen, Faazal Rehman, Markus Heilig, Caleb Pitcairn, Abdul Maruf Asif Aziz, Camilla Karlsson, Don Gehlert, Estelle Barbier
Publikováno v:
Alcoholism: Clinical and Experimental Research. 40:2199-2207
Reward and energy homeostasis are both regulated by a network of hypothalamic neuropeptide systems. The melanin-concentrating hormone (MCH) and its MCH-1 receptor (MCH1-R) modulate alcohol intake, but it remains unknown to what extent this reflects a
Autor:
Jenica D. Tapocik, Andrea L. Johnstone, Bohdan B. Khomtchouk, Claes Wahlestedt, Daniel Nätt, Jesse R. Schank, Eric Augier, D. J. Van Booven, Caleb Pitcairn, A. Borich, Faazal Rehman, Estelle Barbier, Markus Heilig, Hui Sun, C. A. Rienas
Publikováno v:
Europe PubMed Central
Molecular psychiatry
Molecular psychiatry
Epigenetic processes have been implicated in the pathophysiology of alcohol dependence, but the specific molecular mechanisms mediating dependence-induced neuroadaptations remain largely unknown. Here, we found that a history of alcohol dependence pe
Stress-Induced Cellular Clearance Is Mediated by the SNARE Protein ykt6 and Disrupted by α-Synuclein
Autor:
Nandkishore R. Belur, Kristina Fredriksen, Willayat Yousuf Wani, Craig J. Justman, Friederike Zunke, Martino L. Morella, Kotaro Tsutsumi, Aarthi Subramanian, Tom N. Grammatopoulos, Peter T. Lansbury, Caleb Pitcairn, Leah K. Cuddy, Amira Affaneh, Joseph R. Mazzulli
Publikováno v:
Neuron
Summary Age-related neurodegenerative disorders are characterized by a slow, persistent accumulation of aggregated proteins. Although cells can elicit physiological responses to enhance cellular clearance and counteract accumulation, it is unclear ho
Publikováno v:
Neurobiology of Disease, Vol 122, Iss, Pp 72-82 (2019)
The finding that mutations in the Gaucher's Disease (GD) gene GBA1 are a strong risk factor for Parkinson's Disease (PD) has allowed for unique insights into pathophysiology centered on disruption of the autophagic-lysosomal pathway. Protein aggregat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f23424141d55d69b5f0802711b3ddfb
https://europepmc.org/articles/PMC6138580/
https://europepmc.org/articles/PMC6138580/
Autor:
Abbey Borich, Caleb Pitcairn, Hui Sun, Markus Heilig, Jesse R. Schank, Zhifeng Zhou, Kornel E. Schuebel, Leandro F. Vendruscolo, Estelle Barbier, Jenica D. Tapocik, Qiaoping Yuan, David Goldman, Nathan Juergens
Recent studies have suggested an association between alcoholism and DNA methylation, a mechanism that can mediate long-lasting changes in gene transcription. Here, we examined the contribution of DNA methylation to the long-term behavioral and molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c3a959a2a0fa852aa6ff6d626bd368b
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-118052
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-118052
Autor:
Joel E. Schlosburg, Markus Heilig, John P. Williams, Estelle Barbier, George F. Koob, Camilla Karlsson, Kaushik K. Misra, Leandro F. Vendruscolo, Brooke E. Schmeichel, Candice Contet, Caleb Pitcairn, Dimitri E. Grigoriadis
The hypocretin/orexin (HCRT) system has been associated with both positive and negative drug reinforcement, implicating HCRT receptor 1 (HCRT-R1) signaling in drug-related behaviors for all major drug classes, including opioids. However, to date ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3613a133615e490195fe0de1ebb93da1
https://europepmc.org/articles/PMC4367454/
https://europepmc.org/articles/PMC4367454/