Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Caleb Lovelady"'
Autor:
Shinobu Yamaguchi, Randee Sedaka, Chintan Kapadia, Jifeng Huang, Jung-Shan Hsu, Taylor F. Berryhill, Landon Wilson, Stephen Barnes, Caleb Lovelady, Yasin Oduk, Ryan M. Williams, Edgar A. Jaimes, Daniel A. Heller, Takamitsu Saigusa
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract Rapamycin slows cystogenesis in murine models of polycystic kidney disease (PKD) but failed in clinical trials, potentially due to insufficient drug dosing. To improve drug efficiency without increasing dose, kidney-specific drug delivery ma
Externí odkaz:
https://doaj.org/article/280c5588929545ad941f6861d8fa44d3
Autor:
Randee Sedaka, Jifeng Huang, Shinobu Yamaguchi, Caleb Lovelady, Jung-Shan Hsu, Sejal Shinde, Malgorzata Kasztan, David K. Crossman, Takamitsu Saigusa
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
BackgroundDisease severity of autosomal dominant polycystic kidney disease (ADPKD) is influenced by diet. Dietary protein, a recognized cyst-accelerating factor, is catabolized into amino acids (AA) and delivered to the kidney leading to renal hypert
Externí odkaz:
https://doaj.org/article/a83cfa831b3b408c9dda93a8ccb1a86d
Publikováno v:
Physiology. 38
Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disorder, initiated by a germline PKD1 mutation in nearly 80% of patients. Although polycystin-1 (PC-1), the protein encoded by PKD1, is vital to maintaining ren