Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Caleb K. Stein"'
Autor:
Francesco Maura, David G. Coffey, Caleb K. Stein, Esteban Braggio, Bachisio Ziccheddu, Meaghen E. Sharik, Megan T. Du, Yuliza Tafoya Alvarado, Chang-Xin Shi, Yuan Xiao Zhu, Erin W. Meermeier, Gareth J. Morgan, Ola Landgren, P. Leif Bergsagel, Marta Chesi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Multiple myeloma (MM) is a heterogeneous disease characterized by frequent MYC translocations. Sporadic MYC activation in the germinal center of genetically engineered Vk*MYC mice is sufficient to induce plasma cell tumors in which a variety
Externí odkaz:
https://doaj.org/article/0fb36d4f85d4436b947de3da11cd1f2d
Autor:
Cecilia Bonolo de Campos, Yuan Xiao Zhu, Nikolai Sepetov, Sergei Romanov, Laura Ann Bruins, Chang-Xin Shi, Caleb K. Stein, Joachim L. Petit, Alysia N. Polito, Meaghen E. Sharik, Erin W. Meermeier, Gregory J. Ahmann, Ilsel D. Lopez Armenta, Jonas Kruse, P. Leif Bergsagel, Marta Chesi, Nathalie Meurice, Esteban Braggio, A. Keith Stewart
Publikováno v:
Haematologica, Vol 105, Iss 6 (2020)
The cellular cytotoxicity of APY0201, a PIKfyve inhibitor, against multiple myeloma was initially identified in an unbiased in vitro chemical library screen. The activity of APY0201 was confirmed in all 25 cell lines tested and in 40% of 100 ex vivo
Externí odkaz:
https://doaj.org/article/36f9707664964168a6cc9caa0c85b080
Autor:
Francesco Maura, David Coffey, Esteban Braggio, Caleb K Stein, Meaghen E Sharik, Megan T Du, Bachisio Ziccheddu, Gareth J. Morgan, Ola Landgren, P. Leif Bergsagel, Marta Chesi
Publikováno v:
Blood. 140:1540-1541
Autor:
Erin Meermeier, Caleb K Stein, Meaghen E Sharik, Yuan Xiao Zhu, Megan T Du, Seth J Welsh, Chang-Xin Shi, Matthew L Wheeler, P. Leif Bergsagel, Marta Chesi
Publikováno v:
Blood. 140:7056-7057
Publikováno v:
Blood. 140:7082-7083
Autor:
Marta Chesi, Caleb K. Stein, Shaji Kumar, Seth J. Welsh, Yan W. Asmann, P. Leif Bergsagel, Daniel L. Riggs, Erin W. Meermeier, Esteban Braggio, Meaghen E. Sharik, Victoria M. Garbitt, Matteo Bergsagel
Publikováno v:
Blood Cancer Discov
The most common genetic abnormality in multiple myeloma is the deletion of chromosome 13, seen in almost half of newly diagnosed patients. Unlike chronic lymphocytic leukemia, where a recurrent minimally deleted region including MIR15A/MIR16-1 has be
Autor:
Seth J Welsh, Benjamin G Barwick, Erin Meermeier, Daniel Riggs, Chang-Xin Shi, Yuan Xiao Zhu, Meaghen E Sharik, Megan T Du, Victoria Marie Garbitt, Caleb K Stein, Joachim L Petit, Nathalie Meurice, Rodrigo Fonseca, Kennedi Todd, Sochilt Brown, Yuliza Tafoya Alvarado, Zachary Hammond, Nicklus Cuc, Courtney Wittenberg, Camille Herzog, Lawrence H. Boise, Nizar J. Bahlis, Paola Neri, W. Michael Kuehl, Marta Chesi, P. Leif Bergsagel
Publikováno v:
Blood. 140:12997-12997
Autor:
Pavel Strop, P. Leif Bergsagel, Marta Chesi, Megan T. Du, Matthew L. Wheeler, Bryant Chau, Victoria M. Garbitt, Marco Bergsagel, Natalie Bezman, Caleb K. Stein, Chang-Xin Shi, Meaghen E. Sharik, Feng Wang, Daniel L. Riggs, Erin W. Meermeier, Seth J. Welsh
Publikováno v:
Blood Cancer Discov
BCMA/CD3-targeting bispecific antibodies (BsAb) are a recently developed immunotherapy class that shows potent tumor killing activity in multiple myeloma. Here, we investigated a murine BCMA/CD3-targeting BsAb in the immunocompetent Vk*MYC model and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fb9f36adc448e13bc6a0a5e8f268bc3
https://europepmc.org/articles/PMC8266040/
https://europepmc.org/articles/PMC8266040/
Autor:
Qing Zhang, Xenofon Papanikolaou, Al-Ola Abdallah, Shebli Atrash, Bart Barlogie, Caleb K. Stein
Publikováno v:
Journal of Global Oncology, Vol 4, Pp 1-8 (2017)
Journal of Global Oncology
Journal of Global Oncology
Purpose Multiple myeloma (MM) is a clonal bone marrow disease characterized by the neoplastic transformation of differentiated postgerminal B cells. It is a heterogeneous disease both at the genetic level and in terms of clinical outcome. Immunoglobu
Autor:
Megan Du, Lawrence H. Boise, P. Leif Bergsagel, Sochilt Brown, Chang-Xin Shi, Meaghen E. Sharik, Marta Chesi, Kennedi T. Todd, Victoria M. Garbitt, Benjamin G. Barwick, Zachary J. Hammond, Caleb K. Stein, Paola Neri, Nizar J. Bahlis, Daniel L. Riggs, Erin W. Meermeier, Seth J. Welsh, W. Michael Kuehl
Publikováno v:
Blood. 138:1593-1593
Multiple myeloma (MM) is an incurable form of plasma cell cancer in which primary and secondary chromosomal translocations routinely juxtapose oncogenes to plasma cell-specific super-enhancers. Coincidentally, drugs which target super-enhancers have