Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Caleb K. Chan"'
Autor:
Rory M Donovan-Maiye, Jackson M Brown, Caleb K Chan, Liya Ding, Calysta Yan, Nathalie Gaudreault, Julie A Theriot, Mary M Maleckar, Theo A Knijnenburg, Gregory R Johnson
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 1, p e1009155 (2022)
We introduce a framework for end-to-end integrative modeling of 3D single-cell multi-channel fluorescent image data of diverse subcellular structures. We employ stacked conditional β-variational autoencoders to first learn a latent representation of
Externí odkaz:
https://doaj.org/article/01a428aaa62048a293fee6809efd8248
Autor:
Ramon Lorenzo D. Labitigan, Adrian L. Sanborn, Cynthia V. Hao, Caleb K. Chan, Nathan M. Belliveau, Eva M. Brown, Mansi Mehrotra, Julie A. Theriot
The contributions of individual genes to cell-scale morphology and cytoskeletal organization are challenging to define due to the wide intercellular variation of these complex phenotypes. We leveraged the controlled nature of image-based pooled scree
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9209177a33617bbb1236cae999f4654b
https://doi.org/10.1101/2022.12.27.522042
https://doi.org/10.1101/2022.12.27.522042
Autor:
Nathalie Gaudreault, Liya Ding, Jackson M. Brown, Caleb K. Chan, Calysta Yan, Mary M. Maleckar, Rory Donovan-Maiye, Gregory R. Johnson, Theo A. Knijnenburg, Julie A. Theriot
1AbstractWe introduce a framework for end-to-end integrative modeling of 3D single-cell multi-channel fluorescent image data of diverse subcellular structures. We employ stacked conditional β-variational autoencoders to first learn a latent represen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a086f0c69572d9370eadb452911bc2ec
https://doi.org/10.1101/2021.06.09.447725
https://doi.org/10.1101/2021.06.09.447725
Cell motility is a crucial biological function for many cell types, including the immune cells in our body that act as first responders to foreign agents. In this work we consider the amoeboid motility of human neutrophils, which show complex and con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f121aca21140f3cda7dfe76f5dfe54e3
https://doi.org/10.1101/2020.06.26.174474
https://doi.org/10.1101/2020.06.26.174474
Publikováno v:
Biophysical journal, vol 113, iss 9
The cytoplasm of a living cell is a dynamic environment through which intracellular components must move and mix. In motile, rapidly deforming cells such as human neutrophils, bulk cytoplasmic flow couples cell deformation to the transport and disper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f8c7a618adfff2676dca139efa93cd2
https://doi.org/10.1016/j.bpj.2017.09.009
https://doi.org/10.1016/j.bpj.2017.09.009
Autor:
James E. Ferrell, Sean R. Collins, Robert S. Fischer, Anna Huttenlocher, Daniel Irimia, Caleb K. Chan, Pui-ying Lam, Felix Ellett, Michael W. Davidson, Julie A. Theriot, Tobias Meyer, Amalia Hadjitheodorou, Hee Won Yang, Sunny S. Lou, Julianne Jorgensen, Tony Y.-C. Tsai
Publikováno v:
Developmental cell, vol 49, iss 2
Efficient chemotaxis requires rapid coordination between different parts of the cell in response to changing directional cues. Here we investigate the mechanism of front-rear coordination in chemotactic neutrophils. We find that changes in the protru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19909b8386b702865d4465e647cfd3e6
https://escholarship.org/uc/item/6vp4s6d5
https://escholarship.org/uc/item/6vp4s6d5
We describe a technique for deconvolving the stochastic motion of particles from large-scale fluid flow in a dynamic environment such as that found in living cells. The method leverages the separation of timescales to subtract out the persistent comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd730a3477c2ba03131d8ad114c7b725
https://europepmc.org/articles/PMC5658731/
https://europepmc.org/articles/PMC5658731/
Super elongation complexes (SECs) contain two different transcription elongation factors, P-TEFb and ELL1/2, linked by the scaffolding protein AFF4 or AFF1. They stimulate the expression of both normal and disease-related genes, especially those of H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60e93bf74b137d259f5a3f9cf5224f02
https://europepmc.org/articles/PMC3360964/
https://europepmc.org/articles/PMC3360964/
Autor:
Monsef Benkirane, Seemay Chou, Caleb K. Chan, Bijan Sobhian, Nanhai He, Tom Alber, Yuhua Xue, Min Liu, Qiang Zhou
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2011, 108 (36), pp.e636-645. ⟨10.1073/pnas.1107107108⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2011, 108 (36), pp.e636-645. ⟨10.1073/pnas.1107107108⟩
The Super Elongation Complex (SEC), containing transcription elongation activators/coactivators P-TEFb, ELL2, AFF4/1, ENL, and AF9, is recruited by HIV-1 Tat and mixed lineage leukemia (MLL) proteins to activate the expression of HIV-1 and MLL-target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a025658294af0ec647b448836bde93d4
https://doi.org/10.1073/pnas.1107107108
https://doi.org/10.1073/pnas.1107107108