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Enhancement of Triple-Negative Breast Cancer-Specific Induction of Cell Death by Silver Nanoparticles by Combined Treatment with Proteotoxic Stress Response Inhibitors

Autor: Christina M. Snyder, Beatriz Mateo, Khushbu Patel, Cale D. Fahrenholtz, Monica M. Rohde, Richard Carpenter, Ravi N. Singh

Publikováno v: Nanomaterials, Vol 14, Iss 19, p 1564 (2024)

Metal nanoparticles have been tested for therapeutic and imaging applications in pre-clinical models of cancer, but fears of toxicity have limited their translation. An emerging concept in nanomedicine is to exploit the inherent drug-like properties

Externí odkaz: https://doaj.org/article/8c5ededc80444ec19eee27a4b903f4af

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Silver Nanoparticles Selectively Treat Neurofibromatosis Type 1-Associated Plexiform Neurofibroma Cells at Doses That Do Not Affect Patient-Matched Schwann Cells

Autor: Bashnona Attiah, Garrett Alewine, Mary-Kate Easter, Robert A. Coover, Cale D. Fahrenholtz

Publikováno v: Pharmaceutics, Vol 16, Iss 3, p 371 (2024)

Neurofibromatosis Type 1 (NF1) is a common neurogenic condition characterized by heterozygous loss of function mutations in the neurofibromin gene. NF1 patients are susceptible to the development of neurofibromas, including plexiform neurofibromas (p

Externí odkaz: https://doaj.org/article/4c8e457f923f41c38b1827e9a7fcd4a3

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Akademický článek

Silver nanoparticles selectively treat triple‐negative breast cancer cells without affecting non‐malignant breast epithelial cells in vitro and in vivo

Autor: Jessica Swanner, Cale D. Fahrenholtz, Iliana Tenvooren, Brian W. Bernish, James J. Sears, Allison Hooker, Cristina M. Furdui, Elizabeth Alli, Wencheng Li, George L. Donati, Katherine L. Cook, Pierre‐Alexandre Vidi, Ravi Singh

Publikováno v: FASEB BioAdvances, Vol 1, Iss 10, Pp 639-660 (2019)

Abstract Silver nanoparticles (AgNPs) show promise for treatment of aggressive cancers including triple‐negative breast cancer (TNBC) in preclinical cancer models. For clinical development of AgNP‐based therapeutics, it will be necessary to clear

Externí odkaz: https://doaj.org/article/08194cb37e6d42569e52b2e97a9fcfdd

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Akademický článek

Enhancement of Triple-Negative Breast Cancer-Specific Induction of Cell Death by Silver Nanoparticles by Combined Treatment with Proteotoxic Stress Response Inhibitors.

Autor: Snyder, Christina M., Mateo, Beatriz, Patel, Khushbu, Fahrenholtz, Cale D., Rohde, Monica M., Carpenter, Richard, Singh, Ravi N.

Publikováno v: Nanomaterials (2079-4991); Oct2024, Vol. 14 Issue 19, p1564, 19p

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Akademický článek

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