Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins

Autor: Deo, Rahul, Rozenblatt-Rosen, O, Deo, RC, Padi, M, Adelmant, G, Calderwood, MA, Rolland, T, Grace, M, Dricot, A, Askenazi, M, Tavares, M

Publikováno v: Deo, Rahul; Rozenblatt-Rosen, O; Deo, RC; Padi, M; Adelmant, G; Calderwood, MA; et al.(2012). Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/78n0v7zz

Genotypic differences greatly influence susceptibility and resistance to disease. Understanding genotype-phenotype relationships requires that phenotypes be viewed as manifestations of network properties, rather than simply as the result of individua

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::e2de0c86bf6b9553e20ff859cb1b7e88
http://www.escholarship.org/uc/item/78n0v7zz

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Pervasive mislocalization of pathogenic coding variants underlying human disorders.

Autor: Lacoste J; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Haghighi M; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Haider S; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Reno C; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Lin ZY; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, ON, Canada., Segal D; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Qian WW; Department of Computer Science, University of Illinois at Urbana-Champaign, Urbana, IL, USA., Xiong X; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Teelucksingh T; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Miglietta E; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Shafqat-Abbasi H; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Ryder PV; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Senft R; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Cimini BA; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Murray RR; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Nyirakanani C; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Hao T; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., McClain GG; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Roth FP; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, ON, Canada; Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Calderwood MA; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Hill DE; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Vidal M; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Yi SS; Livestrong Cancer Institutes, Department of Oncology, Dell Medical School, The University of Texas at Austin, Austin, TX, USA; Oden Institute for Computational Engineering and Sciences (ICES), The University of Texas at Austin, Austin, TX, USA; Department of Biomedical Engineering, Cockrell School of Engineering, The University of Texas at Austin, Austin, TX, USA; Interdisciplinary Life Sciences Graduate Programs (ILSGP), College of Natural Sciences, The University of Texas at Austin, Austin, TX, USA., Sahni N; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Quantitative and Computational Biosciences Program, Baylor College of Medicine, Houston, TX, USA., Peng J; Department of Computer Science, University of Illinois at Urbana-Champaign, Urbana, IL, USA., Gingras AC; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, ON, Canada., Singh S; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Carpenter AE; Broad Institute of Harvard and MIT, Cambridge, MA, USA. Electronic address: anne@broadinstitute.org., Taipale M; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. Electronic address: mikko.taipale@utoronto.ca.

Publikováno v: Cell [Cell] 2024 Nov 14; Vol. 187 (23), pp. 6725-6741.e13. Date of Electronic Publication: 2024 Sep 30.