Cryptic in vitro ubiquitin ligase activity of HDMX towards p53 is probably regulated by an induced fit mechanism.

Autor: Calderon-González KG; Laboratorio de Interacciones Biomoleculares y cáncer. Instituto de Física Universidad Autónoma de San Luis Potosí, Av. Parque Chapultepec 1570, Privadas del pedregal, 78210, SLP, México., Medina-Medina I; Laboratorio de Interacciones Biomoleculares y cáncer. Instituto de Física Universidad Autónoma de San Luis Potosí, Av. Parque Chapultepec 1570, Privadas del pedregal, 78210, SLP, México., Haronikova L; Regional Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53 Brno, Czech Republic., Hernychova L; Regional Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53 Brno, Czech Republic., Bonczek O; Regional Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53 Brno, Czech Republic., Uhrik L; Regional Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53 Brno, Czech Republic., Hrabal V; Regional Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53 Brno, Czech Republic., Vojtesek B; Regional Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53 Brno, Czech Republic., Fahraeus R; Regional Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53 Brno, Czech Republic.; Department of Medical Biosciences, Umeå University, SE-90185 Umeå, Sweden.; Équipe Labellisée Ligue Contre le Cancer, Université Paris 7, INSERM UMR 1162, 27 Rue Juliette Dodu, 75010 Paris, France., Hernández-Monge J; Catedra CONACyT- Laboratorio de Biomarcadores Moleculares. Instituto de Física, Universidad Autónoma de San Luis Potosí, México City, México., Olivares-Illana V; Laboratorio de Interacciones Biomoleculares y cáncer. Instituto de Física Universidad Autónoma de San Luis Potosí, Av. Parque Chapultepec 1570, Privadas del pedregal, 78210, SLP, México.

Publikováno v: Bioscience reports [Biosci Rep] 2022 Jul 29; Vol. 42 (7).