An immune dysfunction score for stratification of patients with acute infection based on whole-blood gene expression

Autor: Cano-Gamez, E, Burnham, KL, Goh, C, Allcock, A, Malick, ZH, Overend, L, Kwok, A, Smith, DA, Peters-Sengers, H, Antcliffe, D, GAinS Investigators, McKechnie, S, Scicluna, BP, Van der Poll, T, Gordon, AC, Hinds, CJ, Davenport, EE, Knight, JC, Webster, N, Galley, H, Taylor, J, Hall, S, Addison, J, Roughton, S, Tennant, H, Guleri, A, Waddington, N, Arawwawala, D, Durcan, J, Short, A, Swan, K, Williams, S, Smolen, S, Mitchell-Inwang, C, Gordon, T, Errington, E, Templeton, M, Venatesh, P, Ward, G, McCauley, M, Baudouin, S, Higham, C, Soar, J, Grier, S, Hall, E, Brett, S, Kitson, D, Wilson, R, Mountford, L, Moreno, J, Hall, P, Hewlett, J, Garrard, C, Millo, J, Young, D, Hutton, P, Parsons, P, Smiths, A, Faras-Arraya, R, Raymode, P, Thompson, J, Bowrey, S, Kazembe, S, Rich, N, Andreou, P, Hales, D, Roberts, E, Fletcher, S, Rosbergen, M, Glister, G, Cuesta, JM, Bion, J, Millar, J, Perry, EJ, Willis, H, Mitchell, N, Ruel, S, Carrera, R, Wilde, J, Nilson, A, Lees, S, Kapila, A, Jacques, N, Atkinson, J, Brown, A, Prowse, H, Krige, A, Bland, M, Bullock, L, Harrison, D, Mills, G, Humphreys, J, Armitage, K, Laha, S, Baldwin, J, Walsh, A, Doherty, N, Drage, S, Ortiz-Ruiz de Gordoa, L, Lowes, S, Walsh, H, Calder, V, Swan, C, Payne, H, Higgins, D, Andrews, S, Mappleback, S, Hind, C, Watson, D, McLees, E, Purdy, A, Stotz, M, Ochelli-Okpue, A, Bonner, S, Whitehead, I, Hugil, K, Goodridge, V, Cawthor, L, Kuper, M, Pahary, S, Bellingan, G, Marshall, R, Montgomery, H, Ryu, JH, Bercades, G, Boluda, S, Bentley, A, Mccalman, K, Jefferies, F, Knight, J, Davenport, E, Burnham, K, Maugeri, N, Radhakrishnan, J, Mi, Y

Publikováno v: Science translational medicine, 14(669):eabq4433. American Association for the Advancement of Science

Dysregulated host responses to infection can lead to organ dysfunction and sepsis, causing millions of global deaths each year. To alleviate this burden, improved prognostication and biomarkers of response are urgently needed. We investigated the use

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da1e93e689435401be54b99ae67bfdb7
https://doi.org/10.1126/scitranslmed.abq4433

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Conjunctival allergen provocation test : guidelines for daily practice

Autor: Fauquert, J-L, Jedrzejczak-Czechowicz, M, Rondon, C, Calder, V, Silva, D, Kvenshagen, B K, Callebaut, I, Allegri, P, Santos, N, Doan, S, Perez Formigo, D, Chiambaretta, F, Delgado, L, Leonardi, A, Interest Group on Ocular Allergy (IGOA) from the European Academy of Allergy and Clinical Immunology

Conjunctival allergen provocation test (CAPT) reproduces the events occurring by instilling an allergen on the ocular surface. This paper is the compilation of a task force focussed on practical aspects of this technique based on the analysis of 131

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11177a650b524c0e0efcd63555322b99
https://hdl.handle.net/10668/10279

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