Výsledky vyhledávání - "Calcium-Binding Proteins/metabolism"

SALM1 controls synapse development by promoting F-actin/PIP2-dependent Neurexin clustering

Autor: Ka Wan Li, Fatima Farzana, Frank Koopmans, August B. Smit, Jessie W. Brunner, Silvia Oldani, Matthijs Verhage, Marinka Brouwer, Ruud F. Toonen, Ning Chen, Jan R.T. van Weering

Publikováno v: Brouwer, M, Farzana, F, Koopmans, F, Chen, N, Brunner, J W, Oldani, S, Li, K W, van Weering, J R T, Smit, A B, Toonen, R F & Verhage, M 2019, ' SALM1 controls synapse development by promoting F-actin/PIP2-dependent Neurexin clustering ', EMBO Journal, vol. 38, no. 17, e101289 . https://doi.org/10.15252/embj.2018101289
EMBO Journal, 38(17):e101289, 1-20. Nature Publishing Group
EMBO Journal, 38(17):e101289. Wiley-Blackwell
Brouwer, M, Farzana, F, Koopmans, F, Chen, N, Brunner, J W, Oldani, S, Li, K W, van Weering, J R, Smit, A B, Toonen, R F & Verhage, M 2019, ' SALM1 controls synapse development by promoting F-actin/PIP2-dependent Neurexin clustering ', EMBO Journal, vol. 38, no. 17, e101289, pp. 1-20 . https://doi.org/10.15252/embj.2018101289
The EMBO Journal

Synapse development requires spatiotemporally regulated recruitment of synaptic proteins. In this study, we describe a novel presynaptic mechanism of cis‐regulated oligomerization of adhesion molecules that controls synaptogenesis. We identified sy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dccd74ba8c64f4a684dea731fcb80231
https://doi.org/10.15252/embj.2018101289

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Mitochondrial CaMKII causes adverse metabolic reprogramming and dilated cardiomyopathy

Publikováno v: Nature Communications, 11(1). Nature Publishing Group
Nature communications, vol 11, iss 1
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Nature Communications

Despite the clear association between myocardial injury, heart failure and depressed myocardial energetics, little is known about upstream signals responsible for remodeling myocardial metabolism after pathological stress. Here, we report increased m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b15221dfae08cf52c633257c1b0eeff
https://dspace.library.uu.nl/handle/1874/411293

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Role of von Willebrand factor and ADAMTS‐13 in early brain injury after experimental subarachnoid hemorrhage

Autor: Jinglu Ai, R. L. Macdonald, Mervyn D.I. Vergouwen, Shakira Brathwaite, H Ni, Joost C. M. Meijers, H Wan, Yiming Wang, Elly M. Hol

Publikováno v: Journal of Thrombosis and Haemostasis
Journal of Thrombosis and Haemostasis, 16, 1413-1422. Wiley-Blackwell
Journal of Thrombosis and Haemostasis, 16(7), 1413. Wiley-Blackwell
Journal of thrombosis and haemostasis, 16(7), 1413-1422. Wiley-Blackwell

Essentials von Willebrand Factor (VWF) and ADAMTS13 may affect early injury after subarachnoid hemorrhage (SAH). Early brain injury was assessed in VWF−/−, ADAMTS13−/− and recombinant (r) ADAMTS13 treated mice. VWF−/− and rADAMTS13 treate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65b5717ba674e50c8f0ea29e47800996
https://doi.org/10.1111/jth.14136

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S100P is a molecular determinant of E-cadherin function in gastric cancer

Autor: Carla Oliveira, Maria Sofia Fernandes, Ana Margarida Moreira, Sérgia Velho, Raquel Almeida, Fernando Schmitt, Rita Barros, Joana Paredes, Raquel Seruca, Patrícia Carneiro, Patrícia Oliveira, Anabela Ferro, Joana Figueiredo, Fátima Carneiro

Publikováno v: Cell Communication and Signaling, Vol 17, Iss 1, Pp 1-13 (2019)
Cell Communication and Signaling : CCS

Background: E-cadherin has been awarded a key role in the aetiology of both sporadic and hereditary forms of gastric cancer. In this study, we aimed to identify molecular interactors that influence the expression and function of E-cadherin associated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed01826a9abcf54c58d6e3ea10291bc8
https://doi.org/10.1186/s12964-019-0465-9

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Microglia lacking a peroxisomal β-oxidation enzyme chronically alter their inflammatory profile without evoking neuronal and behavioral deficits

Autor: Philip Van Damme, Lien Beckers, Stijn Stroobants, Sander Beel, Ivana Geric, Myriam Baes, Rudi D'Hooge

Publikováno v: Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-15 (2019)
Journal of Neuroinflammation

Background Microglia play a central role in most neurological disorders, but the impact of microgliosis on brain environment and clinical functions is not fully understood. Mice lacking multifunctional protein-2 (MFP2), a pivotal enzyme in peroxisoma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::956cabd117a620008453a8c092f71205
https://doi.org/10.1186/s12974-019-1442-3

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Calcium Fluxes in Work-Related Muscle Disorder: Implications from a Rat Model

Autor: S. Lazar, Karen Søgaard, Jenny Hadrévi, Niels Ørtenblad, Gisela Sjøgaard, Mary F. Barbe, Ulrik Frandsen, Eleanor Boyle

Publikováno v: BioMed Research International, Vol 2019 (2019)
Hadrevi, J, Barbe, M F, Ørtenblad, N, Frandsen, U, Boyle, E, Lazar, S, Sjøgaard, G & Søgaard, K 2019, ' Calcium Fluxes in Work-Related Muscle Disorder : Implications from a Rat Model ', BioMed Research International, vol. 2019, 5040818 . https://doi.org/10.1155/2019/5040818, https://doi.org/10.1155/2019/5040818
BioMed Research International

Introduction. Ca2+ regulatory excitation-contraction coupling properties are key topics of interest in the development of work-related muscle myalgia and may constitute an underlying cause of muscle pain and loss of force generating capacity. Method.

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The cystine-glutamate exchanger (xCT, Slc7a11) is expressed in significant concentrations in a subpopulation of astrocytes in the mouse brain

Autor: Ann Massie, Virgine Veronique Follin-Arbelet, Yun Zhou, Sigrid Ottestad-Hansen, Hideyo Sato, Qiu Xiang Hu, Niels C. Danbolt, Eduard Bentea

The cystine-glutamate exchanger (xCT) promotes glutathione synthesis by catalyzing cystine uptake and glutamate release. The released glutamate may modulate normal neural signaling and contribute to excitotoxicity in pathological situations. Uncertai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::955e3945db56a918d95376b04e60f3a2
http://hdl.handle.net/10852/73005

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The level of hepatic ABCC6 expression determines the severity of calcification after cardiac injury

Autor: Brampton, Christopher, Aherrahrou, Zouhair, Chen, Li-Hsieh, Martin, Ludovic, Bergen, Arthur A B, Gorgels, Theo G M F, Erdmann, Jeannette, Erdfdi, Jeannette, Schunkert, Heribert, Szabó, Zalán, Váradi, András, Le Saux, Olivier

Publikováno v: The American journal of pathology
The American journal of pathology, 2014, 184 (1), pp.159-70. ⟨10.1016/j.ajpath.2013.09.015⟩
American Journal of Pathology, 184(1), 159-70. Elsevier Science
The American journal of pathology, 184(1), 159-70. Elsevier B.V.
American journal of pathology, 184(1), 159-170. Elsevier Inc.

International audience; Because vascular or cardiac mineralization is inversely correlated with morbidity and long-term survival, we investigated the role of ABCC6 in the calcification response to cardiac injury in mice. By using two models of infarc

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https://doi.org/10.1016/j.ajpath.2013.09.015

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Deimination of Human Hornerin Enhances its Processing by Calpain-1 and its Cross-Linking by Transglutaminases

Autor: Anne-Aurélie Raymond, Géraldine Gasc, Chiung-Yueh Hsu, Marie-Claire Méchin, Michel Simon, Odile Burlet-Schiltz, Guy Serre, Hidenari Takahara

Publikováno v: Journal of Investigative Dermatology
Journal of Investigative Dermatology, Nature Publishing Group, 2017, 137 (2), pp.422-429. ⟨10.1016/j.jid.2016.09.030⟩
Journal of Investigative Dermatology, 2017, 137 (2), pp.422-429. ⟨10.1016/j.jid.2016.09.030⟩

International audience; Hornerin (HRNR) shares numerous features with filaggrin, a key contributor to the epidermal barrier functions. The two proteins display a related structural organization, are expressed by the granular keratinocytes as a large

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89c1c44e2292b9bb77b0a9629d6b1232
https://pubmed.ncbi.nlm.nih.gov/27742573

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