Zobrazeno 1 - 10
of 1 830
pro vyhledávání: '"Calcium overload"'
Autor:
Yinyin Xie, Wanwan Zhang, Tingting Peng, Xiaoyi Wang, Xiaolei Lian, Jiao He, Cui Wang, Nanchang Xie
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Mitochondrial calcium overload plays an important role in the neurological insults in seizure. The Rab7 GTPase-activating protein, Tre-2/Bub2/Cdc16 domain family member 15 (TBC1D15), is involved in the regulation of mitochondrial calcium dyn
Externí odkaz:
https://doaj.org/article/5b391d796aff474eaea020449004799d
Autor:
Zhang B, Man J, Guo L, Ru X, Zhang C, Liu W, Li L, Ma S, Wang H, Wang B, Diao H, Che R, Yan L
Publikováno v:
International Journal of Nanomedicine, Vol Volume 19, Pp 7307-7321 (2024)
Boye Zhang,1,2 Jianliang Man,3,4 Lingyun Guo,1 Xiaoxia Ru,1 Chengwu Zhang,1,2 Wen Liu,1,2,5 Lihong Li,1,2,5 Sufang Ma,1,2 Lixia Guo,2,4 Haojiang Wang,1,2 Bin Wang,1,2 Haipeng Diao,1,5 Renchao Che,6,7 Lili Yan1,2,5 1School of Basic Medical Sciences, S
Externí odkaz:
https://doaj.org/article/9682a1b4d33d4aa7a16a0df48875130d
Publikováno v:
Cell & Bioscience, Vol 14, Iss 1, Pp 1-29 (2024)
Abstract Chronic inflammatory musculoskeletal disorders characterized by prolonged muscle inflammation, resulting in enduring pain and diminished functionality, pose significant challenges for the patients. Emerging scientific evidence points to mito
Externí odkaz:
https://doaj.org/article/27532aa9684342d18c9e353d114cbfe2
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 286, Iss , Pp 117162- (2024)
Cadmium (Cd) is a neurotoxicant that gradually accumulates in the human body with age. High Cd burden is correlated with adult hippocampal neurogenesis (AHN) and memory deficits in mammals. However, little knowledge is known about the mechanism by wh
Externí odkaz:
https://doaj.org/article/f776e10b51a246ad9282b73afc2af3a2
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 180, Iss , Pp 117526- (2024)
Objectives: The purposes of this study were to (i) verify the role of CXCR2 in tacrolimus-induced nephrotoxicity, (ii) explore the specific mechanism of CXCR2-mediated tacrolimus nephrotoxicity, and (iii) target the antagonism of CXCR2 and provide a
Externí odkaz:
https://doaj.org/article/93f96fb99fc2462dbc067ed52d207a46
Publikováno v:
Annals of Noninvasive Electrocardiology, Vol 29, Iss 5, Pp n/a-n/a (2024)
ABSTRACT This article describes the case of a 40‐year‐old individual who presented with fulminant myocarditis. Initial ECG displayed sinus tachycardia with a heart rate of 117 bpm, QS complexes in leads V1–V3, ST‐segment depression in leads I
Externí odkaz:
https://doaj.org/article/47063f6a6bd24fbc9f91550a2b78c957
Publikováno v:
Poultry Science, Vol 103, Iss 8, Pp 103891- (2024)
ABSTRACT: Mercuric chloride (HgCl2) is a nephrotoxic contaminant that is widely present in the environment. Selenium (Se) can effectively antagonize the biological toxicity caused by heavy metals. Here, in vivo and in vitro models of Se antagonism to
Externí odkaz:
https://doaj.org/article/417c317f62e44fd2a3aaef1fca21e3fb
Autor:
Chun-qi Yang, Cheng-cai Lai, Jin-chao Pan, Jing Gao, Bao-ying Shen, Yi Ru, Xin Shen, Yufu Liu, Ning-ning Shen, Bo-wei Li, Yu-guang Wang, Yue Gao
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 281, Iss , Pp 116563- (2024)
Evodiamine (EVO), the main active alkaloid in Evodia rutaecarpa, was shown to exert various pharmacological activities, especially anti-tumor. Currently, it is considered a potential anti-cancer drug due to its excellent anti-tumor activity, which un
Externí odkaz:
https://doaj.org/article/e99555e7238842e2967b56d575cd0706
Autor:
Hai-Xia Li, Yan Ma, Yu-Xiao Yan, Xin-Ke Zhai, Meng-Yu Xin, Tian Wang, Dong-Cao Xu, Yu-Tong Song, Chun-Dong Song, Cheng-Xue Pan
Publikováno v:
Journal of Ginseng Research, Vol 47, Iss 6, Pp 755-765 (2023)
Background: Caveolin-1, the scaffolding protein of cholesterol-rich invaginations, plays an important role in store-operated Ca2+ influx and its phosphorylation at Tyr14 (p-caveolin-1) is vital to mobilize protection against myocardial ischemia (MI)
Externí odkaz:
https://doaj.org/article/89a210ecd96d40b99360c9c8c738158a
Autor:
Wei Zhang, Xiaoyan Zhang, Ming Lei, Dunke Zhang, Guangcheng Qin, Jiying Zhou, Lichun Ji, Lixue Chen
Publikováno v:
Antioxidants, Vol 13, Iss 6, p 725 (2024)
Chronic migraine is a disabling disorder without effective therapeutic medicine. AMPA receptors have been proven to be essential to pathological pain and headaches, but the related regulatory mechanisms in chronic migraine have not yet been explored.
Externí odkaz:
https://doaj.org/article/08bcd00126a4419b830101624d9dc761