The antibiotic doxycycline impairs cardiac mitochondrial and contractile function

Autor: Diederik W. D. Kuster, Michel van Weeghel, Vida Alizadeh Tazehkandi, Luciënne Baks-Te Bulte, Gustav J. Strijkers, Bram F. Coolen, Ntsiki M. Held, Bianca J. J. M. Brundel, Riekelt H. Houtkooper, Mariah R R Daal, Marit Wiersma, Rob C. I. Wüst

Publikováno v: Wüst, R C I, Coolen, B F, Held, N M, Daal, M R R, Tazehkandi, V A, Baks-Te Bulte, L, Wiersma, M, Kuster, D W D, Brundel, B J J M, van Weeghel, M, Strijkers, G J & Houtkooper, R H 2021, ' The antibiotic doxycycline impairs cardiac mitochondrial and contractile function ', International Journal of Molecular Sciences, vol. 22, no. 8, 4100 . https://doi.org/10.3390/ijms22084100
International journal of molecular sciences, 22(8):4100. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences, 22(8):4100, 1-19. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences
Volume 22
Issue 8
Wüst, R C I, Coolen, B F, Held, N M, Daal, M R R, Tazehkandi, V A, Baks-Te Bulte, L, Wiersma, M, Kuster, D W D, Brundel, B J J M, van Weeghel, M, Strijkers, G J & Houtkooper, R H 2021, ' The antibiotic doxycycline impairs cardiac mitochondrial and contractile function ', International Journal of Molecular Sciences, vol. 22, no. 8, 4100, pp. 1-19 . https://doi.org/10.3390/ijms22084100
International Journal of Molecular Sciences, 22(8):4100. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences, Vol 22, Iss 4100, p 4100 (2021)

Tetracycline antibiotics act by inhibiting bacterial protein translation. Given the bacterial ancestry of mitochondria, we tested the hypothesis that doxycycline—which belongs to the tetracycline class—reduces mitochondrial function, and results

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba143ec8e34cf744f53dea11e2bd5101
https://doi.org/10.3390/ijms22084100

The Lactate Receptor HCAR1 Modulates Neuronal Network Activity through the Activation of Gα and Gβγ Subunits

Autor: Nadia Rosenberg, Jean-Yves Chatton, Céline Schmuziger, Haissa de Castro Abrantes, Julien Puyal, Leonardo Restivo, Stefan Offermanns, Anne-Bérengère Rocher, Marc Briquet

Publikováno v: The Journal of neuroscience, vol. 39, no. 23, pp. 4422-4433

The discovery of a G-protein-coupled receptor for lactate named hydroxycarboxylic acid receptor 1 (HCAR1) in neurons has pointed to additional nonmetabolic effects of lactate for regulating neuronal network activity. In this study, we characterized t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a1ddc0faab920f78a8b98536bd98952
https://serval.unil.ch/resource/serval:BIB_A7DD5C903273.P001/REF.pdf

Contractile responses to endothelin-1 are regulated by PKC phosphorylation of cardiac myosin binding protein-C in rat ventricular myocytes

Autor: Emma L. Robinson, Anne Segonds-Pichon, Jonas Skogestad, Ioannis Smyrnias, David Oxley, Dagmar Wachten, Jan Magnus Aronsen, Normann Goodwin, Kateryna Demydenko, Martin D. Bootman, H. Llewelyn Roderick, Karin R. Sipido, Sakthivel Sadayappan

Publikováno v: Journal of Molecular and Cellular Cardiology, 117, 1-18. ELSEVIER SCI LTD

The shortening of sarcomeres that co-ordinates the pump function of the heart is stimulated by electrically-mediated increases in [Ca]. This process of excitation-contraction coupling (ECC) is subject to modulation by neurohormonal mediators that tun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b51bea80335f23881775418a1a23db2
https://cris.maastrichtuniversity.nl/en/publications/9352f28b-b397-43a4-be02-91f4e85e1139

Connexins and M3 muscarinic receptors contribute to heterogeneous Ca(2+) signaling in mouse aortic endothelium

Autor: Jean-Louis Bény, Jacques-Antoine Haefliger, François-Xavier Boittin, Loïc Le Gal, Florian Alonso, Florent Allagnat

Publikováno v: Cellular physiology and biochemistry : international journal of experimental cellular physiology bi
Cellular physiology and biochemistry, vol. 31, no. 1, pp. 166-178
Cellular Physiology and Biochemistry, Vol 31, Iss 1, Pp 166-178 (2013)

BACKGROUND/AIMS Smooth muscle tone is controlled by Ca(2+) signaling in the endothelial layer. Mouse endothelial cells are interconnected by gap junctions made of Connexin40 (Cx40) and Cx37 which allow the exchange of signaling molecules to coordinat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f02d6f615050f62607fd6395e5dd8556
http://www.snf.ch

Intercellular calcium waves in primary cultured rat mesenteric smooth muscle cells are mediated by Connexin43

Autor: Nadia Halidi, Florian Alonso, Janis M. Burt, Jean-Jacques Meister, Jacques-Antoine Haefliger, Jean Louis Bény

Publikováno v: Cell Communication and Adhesion, vol. 19, no. 2, pp. 25-37
CELL COMMUNICATION AND ADHESION

Intercellular Ca(2+) wave propagation between vascular smooth muscle cells (SMCs) is associated with the propagation of contraction along the vessel. Here, we characterize the involvement of gap junctions (GJs) in Ca(2+) wave propagation between SMCs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::931deeef8ecc832516bce36d32e0538c
https://doi.org/10.3109/15419061.2012.690792