Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Calcium Channel Binding"'
Publikováno v:
Molecular Brain, Vol 13, Iss 1, Pp 1-11 (2020)
Abstract Calcium dysregulation is a key pathological event in Alzheimer’s disease (AD). In studying approaches to mitigate this calcium overload, we identified the collapsin response mediator protein 2 (CRMP2), an axonal guidance protein that parti
Externí odkaz:
https://doaj.org/article/fddd907120b7432584850e2b01e4da63
Publikováno v:
Molecular Brain, Vol 13, Iss 1, Pp 1-11 (2020)
Molecular Brain
Molecular Brain
Calcium dysregulation is a key pathological event in Alzheimer’s disease (AD). In studying approaches to mitigate this calcium overload, we identified the collapsin response mediator protein 2 (CRMP2), an axonal guidance protein that participates i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ed2c4752e0e986d90b3056196cf7463
http://link.springer.com/article/10.1186/s13041-020-00596-3
http://link.springer.com/article/10.1186/s13041-020-00596-3
Autor:
Karina S. Machado, Marcelo Gonçalves Montes D'Oca, Matheus William Bandeira de Oliveira, João Luis Rheingantz Scaini, Diego da Costa Cabrera, Luiz Eduardo Maia Nery, Adriano Velasque Werhli, Eduarda Santa-Helena, Carla Amorim Neves Gonçalves
Publikováno v:
Life sciences. 259
Aims From the synthesis of 43 lipophilic dihydropyridines, the aim of this study was to verify whether the new dihydropyridines have calcium channel affinity using coupling studies and to determine antihypertensive and antioxidant properties, as well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::024b96d86c6814c7f3b4a24f3bd65000
https://pubmed.ncbi.nlm.nih.gov/32763289
https://pubmed.ncbi.nlm.nih.gov/32763289
Publikováno v:
Cureus
Paraneoplastic neurologic syndromes are a group of immune-mediated, cancer-associated disorders affecting the nervous system. While these syndromes are not understood fully, they are reportedly caused by an immune response against common antigens exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f95cd70e0caa2c67955d6bd7810912b
https://doi.org/10.7759/cureus.3097
https://doi.org/10.7759/cureus.3097
Akademický článek
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Publikováno v:
European Journal of Organic Chemistry. 2009:3258-3264
Ethyl 1,2-dihydro-1,6-dimethyl/6-methyl-2-oxopyrimidine-5-carboxylates react with C-nucleophiles as well as the anion of the enantiopure chiral auxiliary (1R,2S,5R)-(–)-methyl (S)-p-toluenesulfinate to afford 4-substituted and enantiopure congeners
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::009457d993f77a8433e1d9068522aeb3
https://doi.org/10.1002/ejoc.200900208
https://doi.org/10.1002/ejoc.200900208
Autor:
Yoshihiko Nakatani, Kenji Abe, Toshie Kambe, Iku Utsumomiya, Sayako Hotta, Kyoji Taguchi, Yutaka Masuda
Guillain-Barre syndrome is a type of acute inflammatory neuropathy that causes ataxia and is associated with the IgG anti-GM1 antibody. However, the pathogenic role of the IgG anti-GM1 antibody and calcium channels in neuromuscular junctions (NMJs) r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d835615a64b0205de92ac4988bdd6f0
https://europepmc.org/articles/PMC4509117/
https://europepmc.org/articles/PMC4509117/
Autor:
Toshie Kambe, Takumi Nagaoka, Sayako Hotta, Yoshihiko Nakatani, Iku Utsunomiya, Yutaka Masuda, Kyoji Taguchi, Kenji Abe
Publikováno v:
Journal of Neurology and Neurophysiology.
Guillain-Barre syndrome with antibodies against ganglioside N-acetylgalactosaminyl GD1a (GalNAc-GD1a) is characterized by a rapid onset of predominantly distal pure motor neuropathy. However, the pathogenic role of anti- GalNAc-GD1a antibody and calc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5778b646a2320e2c3ea06c9e77626a12
https://doi.org/10.4172/2155-9562.1000275
https://doi.org/10.4172/2155-9562.1000275
Autor:
Diego Cortes, Remedios Tur, Martin Elorriaga, Josefina Magraner, Elsa Anselmi, Maria Dolores Ivorra, Almudena Bermejo, Pilar D'Ocon, Nuria Cabedo, Maria Catret
Publikováno v:
Life Sciences. 67:1535-1548
In the present study we examine the mechanism by which thaligrisine, a bisbenzyltetrahydroisoquinoline alkaloid, inhibits the contractile response of vascular smooth muscle. The work includes functional studies on rat isolated aorta and tail artery p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e4b1048f9e6910cc99329e3598b42e0
https://doi.org/10.1016/s0024-3205(00)00752-9
https://doi.org/10.1016/s0024-3205(00)00752-9
Autor:
Paul K. Pallaghy, Raymond S. Norton
Publikováno v:
The Journal of Peptide Research. 53:343-351
The polypeptide omega-conotoxin GVIA (GVIA) is an N-type calcium channel blocker from the venom of Conus geographus, a fish-hunting cone shell. Here we describe a high-resolution solution structure of this member of the 'inhibitor cystine knot' prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32df511695ea7e32cbe1cd27985a3dd8
https://doi.org/10.1034/j.1399-3011.1999.00040.x
https://doi.org/10.1034/j.1399-3011.1999.00040.x